Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

meso-Tetra(p-sulfophenyl)porphine (TPPS4) has been found to accumulate in the tumors of mice bearing a murine sarcoma virus-induced rhabdomyosarcoma to a greater degree than in all other tissues except for the kidney. Tumor to tissue ratios of from 3:1 (tumor to liver) to 9:1 (tumor to muscle) were observed. The uptake of TPPS4 was found to be dose dependent, and the highest tumor to tissue ratios were found 96 hours after injection. The water-soluble TPPS4 appears to be cleared through the kidneys and absolute concentrations there are reduced with increasing time after injection. These data are compared with previous studies on TPPS4 localization in Walker 256 carcinosarcoma-bearing mice. In view of this localizing ability and its relative lack of toxicity, TPPS4 seems to represent an ideal candidate for a tumor-localizing agent if high levels of the porphyrin in the kidneys can be reversed.
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PMID:Localization of meso-tetra(p-sulfophenyl)porphine in murine sarcoma virus-induced tumor-bearing mice. 20 78

The applicability of five different rodent tumors for experimental PET has been investigated. L-[1-11C]Tyrosine was a better indicator for the growth activity of the tumors than [18F]FDG. For experimental PET, the three mice models studied appeared inappropriate; the Lewis lung tumor and the fibrosarcomateous FIO 26 had too low a tyrosine utilization, while the lymphosarcomateous LY showed insufficient tumor-to-background ratios. Of the two rat models, the necrotic Walker 256 carcinosarcoma was less suitable. By using L-[1-11C]tyrosine, the solid, rhabdomyosarcoma tumor offers good possibilities of monitoring therapeutic interventions with PET.
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PMID:Suitability of rodent tumor models for experimental PET with L-[1-11C]tyrosine and 2-[18F]fluoro-2-deoxy-D-glucose. 191 20

Clones of the rat transplantable tumors: Walker's carcinosarcoma, rhabdomyosarcoma RA-2 and ovary carcinoma, were obtained by means of the lung colony technique and then transplanted subcutaneously and intraperitoneally. Growth parameters of the clones and their transplantants were measured (T, phi = ln2/T, V1). All the tumors gave populations of clones and transplantants with high variability of growth kinetics. There was a positive correlation between growth kinetics of the I and II generation transplantants, and the selection by growth kinetic parameters proved effective. The growth kinetic parameters seem to be quantitative indices with relatively low heritability, and populations of tumor clonogenic cells are heritably heterogeneous by their growth kinetic parameters.
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PMID:[Patterns of the variation in kinetic growth parameters in populations of clones of transplantable rat tumors in vivo]. 683 40