Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

N-myc is a member of the myc oncogene family and has been thought to be specific to neurogenic cells, since it is amplified in some neuroblastomas, retinoblastomas and small-cell lung carcinomas with endocrine properties. Hybridization analyses of DNAs isolated from surgically removed tumors revealed that N-myc was amplified about 6-fold in one of the three embryonic rhabdomyosarcomas examined. The rhabdomyosarcoma containing the amplified N-myc had metastasized into bone marrow, which is preferentially involved in the metastasis of neuroblastomas but is usually not involved in the case of rhabdomyosarcomas. Since rhabdomyoblasts are derived from mesenchyme, this indicates that N-myc gene amplification is not restricted to neurogenic tumors.
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PMID:Amplification of N-myc in a rhabdomyosarcoma. 243 51

The fused gag-v-myc oncogene was microinjected into fertilized mouse eggs, which were then implanted into foster mothers. Approximately 26% of the offsprings from injected eggs carried v-myc sequences. 26 of 32 progeny animals were found to be transgenic and some progeny containing the amplified oncogene (about 40 copies per genome). In one F0 and one F1 mice 1.5-2 months after birth the development of tumors was observed: rhabdomyosarcoma and sebaceous carcinoma. In both the cases the tumors were highly differentiated. Because spontaneous tumors of these types are seldom observed in common lines of mice it seems probable that the tumors observed in this study may be associated with the presence of oncogene v-myc.
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PMID:[Viral myc oncogene in the genome of transgenic mice and their progeny]. 284 17