Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0035412 (
rhabdomyosarcoma
)
6,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TCEA3
is one of three genes representing the transcription elongation factor TFIIS family in vertebrates.
TCEA3
is upregulated during skeletal muscle differentiation and acts to promote muscle specific gene expression during myogenesis.
Rhabdomyosarcoma
(RMS) is a pediatric cancer derived from the muscle lineage, but the expression or function of
TCEA3
in RMS was uncharacterized. We found that
TCEA3
expression was strongly inhibited in RMS cell lines representing both ERMS and ARMS subtypes of RMS.
TCEA3
expression correlates with DNA methylation and we show that TBX2 is also involved in the repression of
TCEA3
in RMS cell lines. Ectopic expression of
TCEA3
inhibited proliferation of RMS cell lines and initiated apoptosis through both the intrinsic and extrinsic pathways. We found that only pan-caspase inhibitors could block apoptosis in the presence of
TCEA3
. While expression of
TCEA3
is highest in skeletal muscle, expression has been detected in other tissues as well, including breast, ovarian and prostate. We found that ectopic expression of
TCEA3
also promotes apoptosis in HeLa, MCF7, MDA-231, and PC3 cell lines, representing cervical, breast, and prostate cancer, respectively. Restoration of
TCEA3
expression in RMS cell lines enhanced sensitivity to chemotherapeutic drugs, including TRAIL. Thus,
TCEA3
presents a novel target for therapeutic strategies to promote apoptosis and enhance sensitivity to current chemotherapeutic drugs.
...
PMID:The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma. 3198 7
