Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0035412 (
rhabdomyosarcoma
)
6,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two children, who had received chemotherapy with doxorubicin and cisplatin for disseminated chondrosarcoma and recurrent
rhabdomyosarcoma
, developed congestive heart failure following treatment with mitoxantrone (
DHAD
); the total doses of
DHAD
were 128 and 90 mg/m2, respectively. The patient with chondrosarcoma had relief of his cardiac symptoms with digitalis and furosemide. The patient with
rhabdomyosarcoma
, whose tumor responded following treatment with
DHAD
, died 2 weeks after development of congestive heart failure. For patients who have received prior treatment with potentially cardiotoxic agents, administration of
DHAD
should be followed by careful monitoring of cardiac function.
...
PMID:Fatal congestive heart failure following mitoxantrone treatment in two children previously treated with doxorubicin and cisplatin. 668 3
