Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transducin-like enhancer of split 1 (TLE1) is a transcription factor known for its strong overexpression and immunopositivity in synovial sarcoma. Several studies have revealed that its immunopositivity is not always specific to synovial sarcoma, with several cases showing positivity in peripheral nerve sheath tumors and solitary fibrous tumors. Occasional weak staining for TLE1 has also been described in clear cell sarcoma, high-grade chondrosarcoma, Ewing sarcoma, rhabdomyosarcoma, GIST, myxofibrosarcoma, and leiomyosarcoma. Here we present the first unique case of sclerosing epithelioid fibrosarcoma with strong, diffuse TLE1 positivity, resulting in a new consideration for the differential diagnosis of TLE1 positivity.
AME Case Rep 2019
PMID:A rare case of TLE1-positive sclerosing epithelioid fibrosarcoma expanding the differential diagnosis of TLE1-positive tumors: a case report. 3102 Feb 73

Rhabdomyosarcoma (RMS) is a soft tissue sarcoma that histologically resembles embryonic skeletal muscle. It is a rare malignancy in adults with a predilection in the head and neck, the genitourinary tract, and other extremities. However, RMS of the gastrointestinal tract is an even rarer condition that merits presentation and discussion. Here, we report on a case of primary duodenal embryonal RMS in an adult.
AME Case Rep 2019
PMID:Primary duodenal embryonal rhabdomyosarcoma in adults: a case report. 3155 85