Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0035412 (
rhabdomyosarcoma
)
6,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Antibodies generated against the whole membrane preparation isolated from
rhabdomyosarcoma
RA-2 cells were shown by immunoblotting and immunoaffinity chromatography to recognize 58-kDa polypeptide,
p58
. The latter was confirmed to be a surface molecule in a test of radioiodination of RA-2 membrane by lodogen. The antibodies added to a suspension of RA-2 cells before their inoculation into rats decreased metastatic activity 50-fold without any noticeable influence on RA-2 proliferation level and viability. The data indicate that masking of
p58
surface antigen by antibodies could make RA-2 cells unable to form experimental metastases in lung. We suggest that
p58
may participate in the specific recognition by RA-2 of lung endothelial cells.
...
PMID:Antibody against p58 surface antigen of RA-2 rat rhabdomyosarcoma cells inhibits their metastatic activity. 145 31
