Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0035412 (
rhabdomyosarcoma
)
6,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The distribution of neutral, or asialosyl-, glycosphingolipids and gangliosides in a
rhabdomyosarcoma
of alveolar type have been studied. Histologically, this muscle tumor is composed primarily of two cell types: one with oval or round hyperchromatic nuclei and very little cytoplasm, and one a giant cell, with multiple, peripherally placed nuclei and weakly staining eosinophillic cytoplasm. In comparing glycolipids of the
rhabdomyosarcoma
with normal muscle from the same leg, the striking alteration in the tumor was a virtual disappearance of ganglioside
GM2
. There was also a slight increase in GM3 and a decrease in GD1a. The asialosyl derivative of
GM2
(GalNac-Gal-Glc-Cer) was markedly increased in the tumor. A loss of glucosylceramide was also observed. The results are discussed in terms of glycolipid metabolic changes in muscle oncogenesis and their implications.
...
PMID:Glycosphingolipids of an alveolar rhabdomyosarcoma and normal human muscle. A case study. 653 79
