Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Long-term results of complete removal of vertebrae with a minimum follow-up period of seven years are reported in 23 consecutive patients from March 1968 to January 1981. Seven patients were treated with vertebrectomy above the sacrum: three for a giant-cell tumor (T11, T12, and L1; T11; and L4), one for chondrosarcoma (one-half T6, T7, and one-half T8), one for chordoma (L3), one for plasmocytoma (L1), and one for a metastasis of renal carcinoma (L1). The latter two patients eventually died of generalized disease, whereas the other five patients have no evidence of tumor after seven to 20 years. In the six patients in whom the spine was reconstructed using corticocancellous iliac bone, a block-vertebra was created by the grafts and the adjacent vertebrae, allowing two women to complete one or more pregnancies successfully. Sixteen patients were treated with removal of sacral vertebrae (from one-half S3, S4, and S5 to all). None of the seven patients treated with adequate surgery for a sacral chordoma has had a local recurrence. Two women have given birth to children after sacral amputations, one performed for rhabdomyosarcoma and the other for a huge ganglioneuroma. A patient treated with a hemicorporectomy for chondrosarcoma 18 years ago has no evidence of tumor.
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PMID:Complete removal of vertebrae for extirpation of tumors. A 20-year experience. 275 35

In spite of an excellent improvement of treatment strategies many questions about the best therapeutic approach in rhabdomyosarcoma remain open. The rate incidence (4,5 per million children and year), the biological heterogeneity, the different localisations and stages of disease still remain a challenge for the interdisciplinary cooperation in paediatric oncology. The optimum treatment consists of a qualified combination of chemo- and radiotherapy as well as surgical intervention. The importance of each modality is to be defined in every individual case. Only with such an approach severe mutilations can be avoided and a better chance of survival offered. A national study for rhabdomyosarcoma of the Austrian Paediatric Oncology Group is presented, which has been established in close collaboration with the paediatric oncologists of West-Germany. The study protocol since January 1982 is still in use. Therapeutic strategies of the Intergroup Rhabdomyosarcoma Study Group were taken into consideration. The chemotherapy essentially consists of a modified T9- and T11-protocol (Memorial Sloan Kettering Cancer Center, New York) including newer drugs like cisplatin and VP16-213. The surgical intervention is recommended as primary resection only when mutilations can be avoided (otherwise a biopsy is proposed). The secondary and definitive resection or biopsy is provided for the time period after completion of 16 weeks of chemotherapy. The addition of radiotherapy after the second look operation promises the maximum of curative effect. The following chemotherapy is planned for further 16 or 36 weeks according to the stage of disease.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Rhabdomyosarcoma in childhood--presentation of a nation-wide Austrian study]. 670 Sep 95

A 7-week-old male black Labrador retriever puppy was presented for post-mortem examination following progressive hindlimb paralysis and multiple masses within the skin. A highly compressive and infiltrative intradural mass was found within the T9-T11 spinal cord. Microscopical and immunohistochemical analysis revealed features compatible with spindle cell rhabdomyosarcoma (RMS). The adjacent spinal cord had numerous melanin-containing cells, arranged in small nodules, predominantly within the grey matter (proposed term of 'micronodular neuromelanocytosis') and the left lateral thorax had multifocal dermal neurofibromas. In this case, the constellation of proliferative/neoplastic lesions represents a unique case presentation with unclear aetiology. Primary canine meningeal RMS of the spinal cord has not been reported previously and represents a novel differential diagnosis for spinal tumours of young dogs. Moreover, such cases should be assessed for the presence of additional congenital abnormalities.
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PMID:Primary Meningeal Rhabdomyosarcoma of the Spinal Cord of a Young Dog with Neuromelanocytosis and Multiple Cutaneous Neurofibromas. 3050 97