Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study consists of 651 cases of soft tissue tumors originating in the head and neck area. Among these tumors 628 were benign (96%), while there were only 23 malignant cases (4%). In the benign group hemangiomas showed the highest incidence (47%) followed by tumors of adipose tissue (19%) and those of peripheral nerves (12%). Rare tumors consisted of nodular fascitis, hibernoma, lipoblastomatosis, glomus tumor, granular cell tumor, and chondroma. The majority of cases in the malignant group were either those of muscle origin or blood vessel origin. Excepting for two cases of rhabdomyosarcoma of the embryonal type and two cases of angiosarcoma, all showed recurrence and/or metastasis and terminated in death. Three cases of liposarcoma of either well-differentiated or myxoid type had a good prognosis with all three living for 3 or more years without any recurrence. Other malignant tumors consisted of malignant schwannoma, fibrosarcoma, malignant fibrous histiocytoma, alveolar soft part sarcoma, and chordoma. The age, sex, anatomical location, and differential diagnosis have also been described.
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PMID:A clinicopathological study on soft tissue tumors of the head and neck. 22 15

The study was concerned with development of parameters to be used in making prognosis of survival in squamous-cell cancer of the skin, fibrosarcoma, malignant fibrous histiocytoma of the bone, leiomyosarcoma, rhabdomyosarcoma, secondary chondrosarcoma, chondroma and osteochondroma. One of them--tumor growth rate--is a maximum tumor size/case history duration ratio (Formula: see text). Other coefficients represent ratios between some characteristics (maximum size or Tt.s) and parameters of a patient's status (height, weight/height ratio, body surface area). A correlation between the suggested coefficients and survival was established.
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PMID:[Clinico-morphological indices for the differential diagnosis and prognosis of the course of a series of malignant tumors]. 282 Jan 46

Six cases of the rarely encountered, advanced tumours of the larynx treated in ENT Clinic of Pomeranian Medical Academy in Szczecin are presented: chondroma, rhabdomyosarcoma, neurinoma, cylindroma and 2 cases of granular cell tumour. There were certain diagnostic difficulties in rhabdomyosarcoma and chondroma cases. The immunocytochemical investigations were of decisive significance in differential diagnosis of the larynx sarcoma. In the case of chondroma there were problems with biopsy taking the tense tissue of the tumour was compressing the subglottic space. The radiological examinations turned out to be very helpful in this case. All patients were treated by surgery, two of them with rhabdomyosarcoma and cylindroma were treated by irradiation too. Observation periods were from 0.5 to 10 years. The oncological and functional results in 4 cases after partial laryngectomies turned out to be satisfactory. All larynx activities were preserved. The patient with sarcoma of the larynx died 6 years after diagnosis of neoplasm. Finally author discuss diagnostic problems and methods of treatment.
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PMID:[Rare tumors of the larynx]. 945 99

We exposed embryos (83 hours postfertilizaton) and fry (3 weeks posthatch) to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by immersion in aqueous solutions of 0-10 ppm for 1 hour (embryo) or 0-2 ppm for 24 hours (fry). Zebrafish embryos were microinjected with MNNG at levels of 0 or 96 ng/egg. Diets containing 0-2,000 ppm MNNG were fed to juvenile zebrafish for 3 months beginning at 2 months posthatch. Fish were sampled for histopathologic study at 6-12 months after initiation of carcinogen exposure. Embryos and fry were both quite responsive to MNNG; however, juvenile zebrafish were remarkably refractory to MNNG-induced neoplasia. Principal target organs in zebrafish treated as embryos with MNNG were liver and testis, with hepatocellular adenoma the most prevalent hepatic neoplasm. A variety of mesenchymal neoplasms occurred in zebrafish following embryo exposure to MNNG, including chondroma, hemangioma, hemangiosarcoma, leiomyosarcoma, and rhabdomyosarcoma. Testis and blood vessels were primary target organs for MNNG following fry exposure, with seminoma, hemangioma, hemangiosarcoma, and various other epithelial and mesenchymal neoplasms occurring. The zebrafish is a responsive, cost-effective lower vertebrate model system in which to study mechanisms of carcinogenesis.
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PMID:Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N'-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages. 1102 8