Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rhabdomyosarcoma is the most common tumor of the lower genitourinary tract in children in the first 2 decades of life. Most cases of genitourinary rhabdomyosarcoma are of the embryonal histologic subtype and include tumors of the bladder, prostate, testes and paratesticular sites, penis, perineum, vagina, and uterus. The natural history, pattern of metastatic spread, treatment, and prognosis of childhood rhabdomyosarcoma vary with the anatomic site of the lesion. In children with rhabdomyosarcoma of the bladder or prostate, presenting signs and symptoms include urinary or fecal retention, dysuria, urinary tract infection, and hematuria. Paratesticular rhabdomyosarcoma produces painless scrotal swelling, which may be ignored until the tumor has reached a large size. Vaginal tumors may manifest as a prolapsing mass in the introitus. Radiologic studies of children with genitourinary rhabdomyosarcoma reflect the nonspecific gross features of the tumor, which may be ill defined with infiltrative margins or well circumscribed by a pseudocapsule of compressed tissue. The botryoid variant of embryonal rhabdomyosarcoma results when submucosal tumor produces a polypoid mass resembling a cluster of grapes within a hollow structure. Botryoid morphology is characteristic, but not specific, for rhabdomyosarcoma within the vagina or urinary bladder, since yolk sac tumor and "tumoral" cystitis may have a similar appearance. Invasion of adjacent structures by the primary tumor may make the precise anatomic origin of genitourinary rhabdomyosarcoma difficult to determine on cross-sectional images. Recent refinements in multidisciplinary therapeutic regimens combining chemotherapy, radiation therapy, and surgery have dramatically improved outcome for children with genitourinary rhabdomyosarcoma. Diagnostic imaging plays an important role in monitoring response to therapy.
 ...
PMID:From the archives of the AFIP. Genitourinary rhabdomyosarcoma in children: radiologic-pathologic correlation. 922 91

Bladder outlet obstruction, either functionally or structurally, could lead to bladder trabeculation, vesicoureteric reflux, hydronephrosis and, eventually, to renal parenchymal damage. If no treatment is given, end-stage renal failure will ensue. The cases of 17 patients of bladder outlet obstruction at National Taiwan University Hospital from 1984 to 1997 were reviewed. Initial presentation, etiology and treatment were discussed. Nine patients were victims of neurogenic bladder and two patients were victims of nonneurogenic neurogenic bladder. Four patients suffered from posterior urethral valve. Ureterocele and urethral rhabdomyosarcoma were noted in one case each. The most common clinical manifestation was urinary tract infection. Ultrasonography, urodynamic study and voiding cystourethrogram were used to delineate the cause and help to decide the appropriate treatment. In conclusion, early detection and prevention of deteriorated renal function are important for children with urinary bladder outlet obstruction.
 ...
PMID:Urinary bladder outlet obstruction in children. 992 10