Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pure rhabdomyosarcomas are extremely rare as primary tumors in the cranial vault. In this instance, a 25-year-old man had symptoms and signs of chronically increased intracranial pressure. A biopsy of the meninges of his posterior fossa was performed revealing a spindle-cell sarcoma. Ultrastructural evidence of striated muscle differentiation and cross striations was present. The patient died of pulmonary emboli. Complete autopsy failed to disclose tumor anywhere except the leptomeninges. The presence of this tumor indicates that a rhabdomyosarcoma can arise from the meninges without a preexisting glioma or teratoma.
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PMID:Diffuse meningeal rhabdomyosarcoma. 719 34

Tumour invasion of the inferior vena cava (IVC) is a complication of retroperitoneal tumours that can be identified at the time of ultrasound B scanning. We have recognized nine patients with proven IVC tumour thrombus from such tumours and have noted several common ultrasound features. Six of these cases were associated with renal carcinoma, two with metastatic teratoma and one with rhabdomyosarcoma. The typical appearance included abnormal echogenic solid material in the lumen of the vessel. In sagittal section the anterior wall was domed as it stretched over the thrombus, and on real time scanning there was loss of the normal venous pulsations. Although similar abnormalities occur with non-tumour thrombus, the presence of these typical features in association with a retroperitoneal tumour is likely to represent tumour invasion of the IVC, an important observation for accurate staging and subsequent management.
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PMID:Ultrasound features of tumour thrombus in the IVC in retroperitoneal tumours. 729 17

This is a report of prospective study of eight patients with testicular tumours seen at the Urology Unit of the Lagos University Teaching Hospital over a five-year period (1979-1983). The mean age was 32.7 years. Four patients (50%) had germ cell tumours including embryonal carcinoma 25%, seminoma 12.5% and malignant teratoma undifferentiated (MTU) 12.5%. The seminoma in this group originated from a testis which was previously undescended but brought into the scrotum at six years of age. The other four patients (50%), had non germ cell tumours. Two of these patients (25%) had paratesticular tumours including rhabdomyosarcoma of paratesticular adnexae and liposarcoma. One (12.5%) had adenomatoid tumour of the epididymis while the last patient (12.5%) had malignant fibrous mesothelioma of the tunica vaginalis. This study reaffirms the fact that testicular tumours are rare in blacks and that Nigeria has the lowest incidence reported at 0.1 per 100,000 per annum.
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PMID:Testicular cancer in Nigerians. 749 39

Imprinted genes mediate unique maternal or paternal genetic roles and their function is essential in prenatal development. The reciprocally imprinted human insulin-like growth factor 2 (IGF2) and H19 genes are expressed during embryonal life, also in the placenta, and are downregulated postnatally. They reexpress in pediatric tumors (e.g. Wilms' tumor) and in inborn developmental syndromes predisposing to such tumors (e.g., Beckwith-Wiedemann syndrome). H19 (RNA transcripts) and IGF2 are manifested in Wilms' tumor, rhabdomyosarcoma, immature ovarian teratoma and gestational trophoblastic diseases. We have found that in the placenta and in urothelial carcinoma, H19 expression reflects the degree of invasiveness. These genes, displaying a tissue-specific oncofetal pattern of expression, are, therefore, tumor markers.
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PMID:Human imprinted genes as oncodevelopmental markers. 807 25

We report a 5-year-old boy with endodermal sinus tumour associated with benign cystic teratoma of the common bile duct (CBD). To our knowledge, there has been one case of teratoma of the CBD in the English literature with no morphological or radiological description. Our case presented a lobulated polypoid mass obstructing the distal CBD on sonography and computed tomography, which resembled the botryoid masses of rhabdomyosarcoma.
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PMID:Endodermal sinus tumour associated with benign teratoma of the common bile duct. 846 96

To further characterize the distribution of tissue-specific antigens in fish neoplasms, juvenile medaka were exposed to 30 mg/L of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 1 hr and allowed to grow out for up to 16 mo. Using a streptavidin peroxidase technique, keratin, vimentin, and neurofilament intermediate filament proteins, and actin and S-100 proteins were labeled in MNNG-induced neoplasms and normal medaka tissues using specific monoclonal or polyclonal antibodies. In vascular tumors, rhabdomyosarcoma, and teratoma, muscle tissues were positive for actin. Other sarcomas including hemangiopericytoma, fascial sarcoma, and undifferentiated sarcoma were negative for all antibodies tested. An unusual scale-associated neoplasm, composed of clusters of scale-forming cells surrounding spicules of scale, had keratin-positive stroma. The epithelial neoplasms were also positive for keratin, except for pancreatic acinar carcinoma, which had limited positivity. Both teratoma and olfactory carcinoma had S-100-positive intraepithelial cells morphologically reminiscent of neurosensory epithelial cells, which were S-100 positive in normal tissues. Although positive reactivity in fish tissues correlated with mammalian data, the antibodies used were raised against mammalian antigens. Therefore, a negative reaction may be indicative of lack of antibody sensitivity to specific fish antigens rather than absence of the antigen in the tissues. However, these data show that tissue-specific antigen detection may assist in elucidating the biology of neoplasia in fish.
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PMID:Reactivity of tissue-specific antigens in N-methyl-N'-nitro-N-nitrosoguanidine-induced neoplasms and normal tissues from medaka (Oryzias latipes). 873 89

To test the sensitivity of the small fish species Oryzias latipes to the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), medaka were exposed at 15 days of age to 30 mg/L for 1 hr and followed for up to 16 mo. One hundred neoplasms were diagnosed in 84 of 213 exposed fish, with approximately equal percentages in males and females. Many neoplasms (62%) were of mesenchymal origin and were categorized as blood vascular neoplasms (hemangioma and hemangiosarcoma), invasive sarcomas, and scale-associated neoplasms. Invasive sarcomas included rhabdomyosarcoma, fascial sarcoma, hemangiopericytoma, and undifferentiated sarcoma. A scale-associated neoplasm, termed lepidocytoma, was an unusual neoplasm of scale anlage. Thyroid follicular neoplasms, with a 100% incidence in males, and pancreatic acinar carcinoma were the most common epithelial tumors. Neoplasms of the gills, swim bladder, and olfactory epithelium were also seen as well as teratoma with mixed epithelial and mesenchymal components. The study showed a broad range of neoplasms induced by MNNG in medaka, with a tissue distribution that might support direct action on exposed tissues.
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PMID:N-methyl-N'-nitro-N-nitrosoguanidine-induced neoplasms in medaka (Oryzias latipes). 873 88

Heart neoplasms are of increasing interest among clinicians and surgeons. A review of primary malignant cardiac tumors, secondary cardiac tumors and carcinoid heart tumors is presented, with special reference to their pathological and surgical aspects. Primary malignant heart tumors represent about 25% of all cardiac tumors, the great majority are sarcomas and the whole family of this group is described including angiosarcoma, rhabdomyosarcoma, fibrosarcoma, leiomyosarcoma, liposarcoma, neurogenic sarcoma, synovial sarcoma and osteosarcoma; mesothelioma, lymphoma, malignant teratoma and thymoma are also included. Metastatic heart tumors are 20-40 times more common than primary malignancies, their behavior and more relevant aspects in diagnostic and surgical therapy are mentioned. Carcinoid heart tumors represent a distinctive entity and are discussed individually.
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PMID:[Cardiac tumors (II). Malignant primary tumors. Metastatic tumors. Carcinoid tumor]. 954 34

A 27-year-old man was referred to us for resection of a post-chemotherapy growing mass in the mediastinum. He had been treated with 4 courses of combination chemotherapy for his testicular cancer. The primary lesion was burned out and the anterior mediastinal metastatic tumour contained immature teratoma. After normalization of tumour marker levels, the mediastinal mass was resected completely and the resected specimen showed teratoma with rhabdomyosarcoma. Two rare clinical conditions have been seen in this case.
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PMID:Growing mediastinal metastatic tumour in a patient with burned out testicular cancer. 960 89

The occurrence of sarcoma in a benign cystic teratoma is very rare. We report the first poorly differentiated, malignant mixed mesodermal tumor with a component of rhabdomyosarcoma to arise in a benign cystic teratoma of the ovary. The tumor was staged as FIGO IC due to capsule invasion. Although combination chemotherapy of cisplatin, ifosfamide and mesna, was instituted, the disease took a rapidly progressive course. After an unusual metastasis to the scapula was detected, the patient deteriorated and died in the forth postoperative month.
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PMID:Malignant mixed mesodermal tumor arising in a benign cystic teratoma. 1039 31


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