Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The correction of marked blepharoptosis in patients with severe or potential keratopathy will worsen the keratopathy and possibly lead to the complications of corneal ulceration and endophthalmitis. The conjunctival flap--cosmetic shell--ptosis procedure is well suited to this difficult management problem. Patients are initially treated with a conjunctival flap to protect their cornea. Subsequently they are fit with a cosmetic shell, and finally they undergo surgery to correct their ptosis. This three-stage procedure has produced excellent cosmetic and functional results in two patients, one of whom had ptosis and severe radiation-induced keratopathy following the treatment of a rhabdomyosarcoma; the other patient had severe ptosis associated with lack of corneal sensation and orbicularis function following removal of a cerebral meningioma.
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PMID:Conjunctival flap-cosmetic shell-ptosis procedure. Treatment of blepharoptosis in severe keratopathy. 259 74

Late effects of therapy were evaluated in 50 children surviving orbital rhabdomyosarcoma following treatment on Intergroup Rhabdomyosarcoma Study I. All patients had microscopic or gross tumor present following surgery and subsequently received radiotherapy and various combinations of chemotherapeutic agents. Problems in the eye included infections and functional and structural changes. Decreased vision in the treated eye was the most common functional problem and in most patients related to cataract formation, which occurred in 90% of eyes. Changes in the cornea and retina were also seen. Bony hypoplasia of the orbit and facial asymmetry were present in one half of the children. Gonadal development was normal. Statural growth was retarded in 61% of the patients. All children were in school, with five having learning or behavioral problems. One child developed acute myeloblastic leukemia. The excellent survival in patients with orbital rhabdomyosarcoma provides support for treatment programs that use multiple-agent chemotherapy and radiotherapy and do not include orbital exenteration initially.
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PMID:Late effects of therapy in orbital rhabdomyosarcoma in children. A report from the Intergroup Rhabdomyosarcoma Study. 395 18

The inhibition of herpes simplex virus type 1 (HSV-1) plaque formation by acycloguanosine (ACG) was assayed in human fetal lung fibroblasts (HL), cell lines from human cervical carcinoma, rabbit cornea, and human rhabdomyosarcoma, and three green monkey kidney cell lines. The ACG concentration giving 50% plaque reduction (PR50) of HSV-1 was lowest in HL. In two green monkey kidney cell lines, HSV-1 plaque formation was relatively insensitive to ACG, with PR50 of 25 and 60 muM, respectively. In the other cells, HSV-1 showed an intermediate sensitivity to ACG. Also, HSV-2 was more sensitive to ACG in HL than in monkey kidney cells. HSV-1 plaque reduction on HL cells was studied as a function of increasing virus MOI with a constant concentration of ACG. An increased MOI decreased the sensitivity to ACG. The sensitivity of cytomegalovirus (CMV), strain Ad. 169, and four fresh CMV isolates to ACG was studied in HL cells. At low MOIs, three of the five CMV strains were somewhat sensitive to ACG, PR50 values ranging from 60 to 450 muM ACG. At high MOIs none of the virus strains were sensitive. ACG at concentrations of 200 muM or less did not significantly affect host cell DNA synthesis, as measured by 3H-thymidine incorporation. In cell culture, the inhibition of herpesviruses by ACG appears to be complex, depending on the type of virus, virus concentration, type of host cells, and condition of the cells.
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PMID:Influence of cells and virus multiplicity on the inhibition of herpesviruses with acycloguanosine. 626 98