Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035078 (renal failure)
 31,970 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

26 patients with clinical and biological suspicion of acute pancreatitis were examined by MRI. The general indications for pancreatic MRI were: suboptimal or equivocal CT or ultrasonography findings (e.g. focal pancreatic enlargement with no mass discernable on CT or US), contraindications to iodinated contrast administration (e.g. contrast allergy history and renal failure). Using fast scanning techniques most of them with breath holding and fat saturation MRI was able to depict the lesions involved (e.g. the presence and distribution of necrotic areas and fluid collections, the existence of subsequent chronic pancreatic changes) which are consistent with CT findings. MRCP demonstrated etiology, like cholelithiasis.
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PMID:[MRI in acute pancreatitis]. 1661 Jan 69

Hypoxia of renal medulla is a key factor implicated in the development of drug-induced renal failure. Drugs are known to influence renal hemodynamics and, subsequently, affect renal tissue oxygenation. Changes in renal oxygenation can be assessed non-invasively in humans using blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI). This study was designed to test the acute effects of administration of specific drugs in healthy human kidney oxygenation using BOLD-MRI. Acute changes in renal tissue oxygenation induced by the non-steroidal anti-inflammatory drug indomethacin, the iodinated radio-contrast media (RCM) iopromidum, and the calcineurin inhibitors cyclosporine micro-emulsion (CsA-ME) and tracrolimus were studied in 30 healthy volunteers. A modified Multi Echo Data Image Combination sequence was used to acquire 12 T(2)(*)-weighted images. Four coronal slices were selected to cover both kidneys. The mean R(2)(*) (1/T(2)(*)) values determined in medulla and cortex showed no significant changes induced by indomethacin and tacrolimus administration. CsA-ME decreased medullary (P=0.008) and cortical (P=0.004) R(2)(*) values 2 h after ingestion. Iopromidum caused a significant increase in medullary R(2)(*) within the first 20 min after injection (P<0.001), whereas no relevant changes were observed in renal cortex. None of the measurements showed left-right kidney differences. Significant differences in renal medullary oxygenation were evidenced between female and male subjects (P=0.013). BOLD-MRI was efficient to show effects of specific drugs in healthy renal tissue. Cyclosporine increased renal medullary oxygenation 2 h after ingestion of a single dose, whereas indomethacin and tacrolimus showed no effect on renal oxygenation. Injection of iodinated RCM decreased renal medullary oxygenation.
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PMID:BOLD-MRI for the assessment of renal oxygenation in humans: acute effect of nephrotoxic xenobiotics. 1681 Feb 86

A 31-year-old man was admitted to our hospital, complaining of muscular weakness and pain in the legs one month after a common cold. On admission, neurological examinations demonstrated moderate weakness in the arms and mild weakness in the legs with decreased or diminished deep tendon reflexes, and mild dysphagia. Weakness was gradually extended to the arm, throat and respiratory muscles, requiring artificial ventilation. Laboratory examinations demonstrated increased levels of CK (upto 24,380 IU/L) and positive anti-cytomegalovirus (CMV) -IgM antibodies in the serum, and myogloburinuria. CMV was not detected in either the blood cells or muscles by PCR. There were no antibodies against viruses including Ebstein-Barr virus and HIV, in the serum. There were no autoantibodies related to collagen diseases in the serum. Systemic PET scan did not show any evidence of malignancy. Bone marrow biopsy did not show any atypical cells. Muscle MRI demonstrated mild atrophy with high intensity signals in part. Muscle biopsy demonstrated scattered necrotic and regenerated muscle fibers without inflammatory cell infiltration. The patient was therefore diagnosed as having rhabdomyolysis associated with CMV infection. After three courses of intravenously administered high dose methylprednislone over three days, muscle weakness improved gradually, and the serum CK level was normalized in two months. The patient recovered and was removed from artificial ventilation three months after the therapy. There were no sign of renal failure. Steroid therapy should be considered for the treatment of rhabdomyolysis or myopathy associated with CMV infection in order to prevent renal failure or fatal progression of the disease.
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PMID:[A steroid-responsive case of severe rhabdomyolysis associated with cytomegalovirus infection]. 1688 96

A 32-year-old male patient presented in the emergency department of our hospital with acute vomiting and diarrhoea. He reported occasional non-severe diarrhoea over several years in the past. Furthermore, at the time of presentation the patient had had anuria for several days. A prerenal and postrenal origin of the renal failure was excluded. A renal biopsy was performed and histopathological examination displayed findings consistent with a haemolytic-uraemic syndrome but no signs of glomerulonephritis. MRI examination of the small bowel revealed inflammatory alterations typical for Crohn's disease, even without histological verification. We describe haemolytic-waemic syndrome as manifestation of Crohn's disease for the first time.
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PMID:[A 32-year-old patient with diarrhoea and acute kidney failure]. 1761 97

Cerebral venous thrombosis (CVT) in children is a multifactorial serious disease. It is being increasingly diagnosed, mainly because of more sensitive diagnostic procedures and increasing clinical awareness. The clinical manifestations can be life-threatening and cause long-term neurological deficits. Thromboembolism in children is a multifactorial disorder in which both genetic and acquired risk factors play a role. CVT occurs in various clinical settings, including infection, dehydration, renal failure, trauma, cancer and haematological disorder with multiple risk factors. Clinical manifestations of CSVT are nonspecific and may be subtle. Most of the clinical scenarios occur at all ages and the clinician should consider this diagnosis in a wide range of acute neurological presentations in childhood. CVT can have an extremely variable clinical presentation, mode of onset, imaging appearance and outcome. Its prognosis remains largely unpredictable. Diffusion and perfusion MRI may play a role in detecting venous congestion and CT or MR venography are now the methods of choice for investigation of cerebral venous thrombosis. The options for treatment of infants and children include standard or low molecular weight heparin for 7-10 days followed by oral anticoagulants for 3-6 months. Specific treatment with anticoagulation is controversial in children, but has been established as appropriate therapy in adults. Anticoagulant treatment with heparin is probably safe and beneficial for children with sinus thrombosis, even those with intracranial haemorrhages.
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PMID:Paediatric cerebral venous thrombosis. 1718 84

A 68-year-old male patient with end-stage renal failure on maintenance hemodialysis using a right internal jugular dual-lumen catheter developed thrombosis of the internal jugular vein with extension into the superior vena cava after removal of the catheter. As he developed a lower backache with MRI finding of disease of the D11 and D12 vertebrae, a bone biopsy performed showed multiple myeloma. Anticoagulant therapy led to recanalization of the thrombosed veins.
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PMID:Multiple myeloma and hypercoagulability leading to internal jugular vein thrombosis in a dialysis patient. 1725 53

We report the case of a 28-year-old woman who presented simultaneously with superior sagittal sinus thrombosis and thyroid crisis, and was subsequently found to have protein C deficiency. February 3, 2003, she admitted complaining of abdominal pain. The diagnosis of appendicitis was made, and she was operated on under lumbar anaesthesia. Day 7, she developed acute headache and distal weakness of the left lower limb. On examination she was alert, with a temperature of 38 degrees C, a sinus tachycardia of 124/min and blood pressure 164/84 mmHg. Neurological examination revealed neck stiffness and left hemiparesis, predominantly in her lower limb. Gadlinium-enhanced brain MRI revealed extensive superior sagittal sinus thrombosis. CT scan demonstrated infarction in the right frontal cortex, and subarachnoid hemorrhage adjacent to the right cerebellar tentorium. The patient was treated with a free radical scavenger edarabon, and glycerin. No anticoagulant therapy was instituted. Over the next 24 hours, her condition worsened. She became comatose, as well as developing a generalized tonic-clonic seizure. Day 12, laboratory examinations revealed an undetectable TSH-level CTSH (thyroid stimulating hormone) <0.005 mcIU/ml), with a level of free thyroxin 7.77 ng/dl (0.9-1.7), free triiodothyronin 29.6 pg/ml (2.3-4.3), and positive anti-TSH receptor antibodies determined subsequently. Coagulation factor VIII activity was 155% (normal range 60-150). Protein C deficiency (antigen 59%, activity 49%) was also present, suggesting a congenital type I heterozygous deficiency. A diagnosis of thyroid crisis on the basis of Graves' disease was made. The patient remained comatose and died on Day 16, with renal failure. The patient had protein C deficiency, a well-established risk factor for cerebral venous thrombosis (CVT). However, additional risk factors are required in most cases to precipitate CVT. In our case, this trigger was most likely thyroid crisis, suggesting that thyrotoxicosis, probably through hypercoagulability, may be a predisposing factor for the development of CVT.
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PMID:[Thyroid crisis and protein C deficiency in a case of superior sagittal sinus thrombosis]. 1737 Jun 53

US is frequently used as the initial imaging in patients with suspected renal disease. US contrast agents offer the potential to increase the sensitivity in patients who cannot undergo CT or MTI. Harmonic imaging has helped with the evaluation of renal cystic lesions. CT remains the reference standard for staging and lesion characterization. The rapid technological advances mean that ultra-thin slices and 3D imaging have now become more widely available. MRI has also greatly advanced in speed and image quality, but at present, imaging time and scanner availability mean that MRI is generally used as a problem-solving tool. It is particularly helpful for smaller lesions and complex cystic lesions, where subtraction can be used to accurately identify the presence of enhancement. MRI is used as the primary diagnostic tool for patients with radiation concerns and those with renal failure. Caution must now also be taken in these patients, given the recent studies raising the association of gadolinium-based compounds and NSF. There have been dramatic improvements in renal imaging over the last decade, offering better resolution, shorter imaging times and better patient acceptance. The progress in minimally invasive techniques has driven the need to provide better preoperative information to the surgeon. The future of renal imaging is an exciting field; perhaps with fluorodeoxyglucose-based positron emission tomography we will be able to predict the biological behaviour of a tumour, and molecular imaging agents will become available to identify and hopefully treat specific tumour types.
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PMID:Update on radiological imaging of renal cell carcinoma. 1744 14

Vesicoureteric reflux (VUR) is a well-recognized entity in the paediatric population, but is not well described or understood in the adult population. This is partly explained by the fact that its incidence declines with advancing age. Its diagnosis is, however, still important, with VUR accounting for at least 10% of adult patients with end-stage renal disease. With early detection and careful management, the secondary complications of VUR such as renal failure can be prevented. Imaging plays a major role in the detection and evaluation of VUR in the adult patient. Conventional techniques such as micturating cystourethrograms have now been supplemented by cross-sectional imaging with CT and MRI. In this review article, we comprehensively review the up to date status of imaging the adult patient with VUR and discuss important subgroups of patients such as pregnant and transplant patients.
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PMID:Vesicoureteric reflux in the adult. 1768 74

Nephrogenic systemic fibrosis (NSF) is a fibrotic disease seen in renal failure patients that may lead to severe physical disability. It has been demonstrated in recent studies that NSF can be caused by some gadolinium-containing MRI contrast agents. In this report we present one of a total of 26 cases of gadodiamide-related NSF from our hospital.
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PMID:Nephrogenic systemic fibrosis: a serious iatrogenic disease of renal failure patients. 1793 86


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