Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035078 (renal failure)
 31,970 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

On in-patient basis 24-hr electrocardiographic Holter monitoring was performed in 20 patients with chronic renal failure (c.r.f.) on conservative treatment (10 women and 10 men, aged 43.6 +/- 9.8 years), in 10 patients with chronic primary glomerulonephritis without arterial hypertension and renal failure (2 women and 8 men, aged 34.2 +/- 10.5 years), and in 10 patients with primary arterial hypertension without clinical symptoms of renal disease (1 woman and 9 men, aged 36.6 +/- 9.5 years). No atrio-ventricular conduction disturbances were found in patients with c.r.f. Supraventricular and ventricular arrhythmias occurred in 90% of the patients. Ventricular arrhythmias were observed in 8% of c.r.f. patients. Among them simple ventricular extrasystoles (Lown 0-3) predominated and they were found in 65% of the patient. Numbers of ventricular extrasystoles were small and amounted to 44.7 per 24 hrs. Cardiac arrhythmias registered in both comparative groups were not different from those found in c.r.f. patients. The results suggest that chronic renal failure in patients on conservative treatment does not peculiarly predispose to the occurrence of cardiac arrhythmias.
Pol Arch Med Wewn 1993 Dec
PMID:[Clinical analysis of cardiac arrhythmias in patients with chronic renal failure treated conservatively. I. Evaluation of cardiac arrhythmias]. 814 48

Cardiac arrhythmias detected during 24-hr electrocardiographic Holter monitoring were correlated with some echocardiographic indices in 20 patients chronic renal failure (c.r.f.) on conservative treatment (10 women and 10 men, aged 43.6 +/- 9.8 years). Comparative groups consisted of 10 patients with chronic primary glomerulonephritis without arterial hypertension and renal failure (2 women and 8 men, aged 34.2 +/- 10.5 years), and 10 patients with primary arterial hypertension without clinical symptoms of renal disease (1 woman and 9 men, aged 36.6 +/- 9.5 years). In c.r.f. patients echocardiographic investigations disclosed that the left atrial diastolic dimension was within a normal range. The right ventricular diastolic dimension (RVDD) was, left ventricular systolic (LVDS) and diastolic (LVDD) dimensions and left ventricular end-diastolic volume (LVEDV) were slightly increased. The left ventricular ejection fraction (EF) was significantly lowered. In c.r.f. patients the left ventricular mass (LVM) was increased to approximately 300 g. In c.r.f. patients a significant positive correlation was found between number of ventricular extrasystoles registered within 24 hrs and RVDD. The investigation disclosed that: 1) in c.r.f. patients with arterial hypertension showed ultrasonographic signs of hypertrophic-dilated cardiomyopathy with impaired left ventricular ejection fraction; 2) in c.r.f. patients incidence and nature of cardiac arrhythmias were independent of LVM, LVDD and LVDS; 3) numbers of ventricular extrasystoles registered within 24 hrs can increase with the increase in RVDD and the decrease in EF.
Pol Arch Med Wewn 1993 Dec
PMID:[Clinical analysis of cardiac arrhythmias in patients with chronic renal failure treated conservatively. II. Evaluation of the relationship between cardiac arrhythmias and some echocardiographic indices--preliminary investigations]. 814 49

The studies were aimed at the determining the serum amikacin levels during the treatment of urinary tract infection as an attempt to monitor this treatment. The study involved 51 patients. Amikacin profile following a single dose of 500 mg i.m. was studied in group 1 (n = 7) while the administration of 2 daily doses of 500 mg for 7 days was investigated in group 2 (24 patients with normal renal functioning). Group 3 (10 patients with renal failure) was given the same amikacin doses for 5 days. Amikacin dosage was modified with the own computer program in group 4. Both lower and peak amikacin serum levels in the groups 1, 2 and 3 ranged markedly from subtherapeutical to toxic. Blood urea and creatinine increased significantly in groups 2 and 3. In group 4 amikacin peak level exceeded in therapeutical value only in out patient, and no an increase in blood creatinine or urea was noted during a 5-day therapy.
Pol Tyg Lek
PMID:[Monitoring treatment with amikacin for urinary tract infections]. 817 Aug 15

Two cases of pseudomembranous colitis in patients with renal failure are presented. Both patients were treated with antibiotics. Clinical course, bacteriologic examination of feces, and endoscopy of the colon plays an important role in the diagnosis of this complication. No gut endoscopy was performed in both patients due to severe disease course. Pseudomembranous colitis was diagnosed by clinical symptoms and bacteriologic examination of feces out of which C. difficile was isolated. Teicoplanin-a drug of a known efficiency in the treatment of C. difficile infection-was given and vancomycin was used in the second patient. We would like to stress that renal failure predisposes to the a development of pseudomembranous colitis. An emphasis is also on the dose adjustments of drugs in renal failure.
Pol Tyg Lek
PMID:[Pseudomembranous colitis in patients with kidney failure]. 817 Aug 19

The effectiveness of pulse-dose intravenous steroid treatment was studied in acute phase of lupus nephritis with renal failure rapidly progressive despite conventional therapy. On 5-6 consecutive days 1g of prednisolone or methylprednisolone was given intravenously to 33 patients with a mean initial serum creatinine 5.9 +/- 4.1 mg/dl (521.6 +/- 362.4 mumol/l); then the patients were placed on conventional therapy. Immediate remission (group I), lasting at least 6 months, was achieved in 23 patients (69.7%), with a significant decrease of serum creatinine from 4.5 +/- 3.2 mg/dl (397.8 +/- 282.9 mumol/l) to 1.3 +/- 0.7 mg/dl (114.9 +/- 61.9 mumol/l) (p < 0.001) within 3 months. In 19 patients the remission lasted more than a year; till now the longest one is 13 years. In 10 patients (group II), the therapy brought no improvement and they went quickly into terminal renal failure. In this group the initial serum creatinine was 8.9 +/- 3.6 mg/dl (786.8 +/- 318.2 mumol/l), which was much higher than in the I group. All those patients were admitted to chronic dialysis programme; however, 5 of them died during the first 3 months of the treatment. The most frequent complications of the therapy were infections; all but one (a generalized zoster being a cause of death) caused no therapeutic difficulties. Pulse-dose intravenous steroid treatment makes achieving rapid clinical remission possible even in cases of advanced renal failure due to acute phase of lupus nephritis, refractory to conventional therapy.
Pol Arch Med Wewn 1993 Jan
PMID:[Pulsed dose intravenous steroid treatment in the therapy of acute lupus nephritis with renal failure]. 847 46

The aim of this study was to evaluate the clinical usefulness of the calcitonin test in predicting the hyperparathyroid bone disease severity in uremia. 200 IU of synthetic salmon calcitonin was given intranasally to 77 hemodialysed patients with end-stage renal failure. Before the test, serum calcium, PTH and serum alkaline phosphatase had been sampled; serum calcium was determined also in 2 to 4 hours after. The subjects were divided into 3 groups according to their serum PTH levels. Group I consisted of 24 patients with at least 10-fold serum PTH elevation, group II of 34 patients with intermediate values, and group III of 19 patients with serum PTH within normal range. In the group I the mean serum calcium fall was 0.32 +/- 0.16 mmol/l (1.28 +/- 0.64 mg/dl) (p < 0.001) and 0.27 +/- 0.15 mmol/l (1.08 +/- 0.60 mg/dl) (p < 0.001), after 2 to 4 hours respectively. In the group II serum calcium decreased by 0.16 +/- 0.12 mmol/l (0.64 +/- 0.48 mg/dl) after 2 hours and by 0.14 +/- 0.09 mmol/l (0.56 +/- 0.36 mg/dl) after 4 hours; the differences were statistically insignificant. In the group III no reduction in serum calcium was observed. In the whole 77 patients population significant linear correlations between the hypocalcemic response and iPTH as well as serum alkaline phosphatase were found. Our results confirm that the calcitonin-induced hypocalcemia a test can be, in addition to serum alkaline phosphatase and PTH evaluation, a simple and useful index of advanced hyperparathyroid bone disease in hemodialysed patients with chronic renal failure.
Pol Arch Med Wewn 1993 Feb
PMID:[Test with calcitonin as an index of parathyroid function in chronic renal failure]. 850 92

Increased susceptibility to infection is observed in patients with chronic renal failure (CRF). Therefore, when antibiotic therapy is indicated, it is reasonable to use a drug which is usually reserved as a second-choice antibiotic in other patients. Antibiotic prevention before surgical procedures with a high risk of infection, especially before renal transplantation is also often necessary. Evaluation of Biotrakson (ceftriakson) (produced in Poland) efficacy in patients with CRF was the aim of this study. The antibiotic was administered in a single, complete prophylactic dose or once daily when given therapeutically in 25 patients: 13 with end-stage renal disease treated with hemodialysis, 5 with end-stage renal disease treated with peritoneal dialysis, 4 with chronic renal failure, 1 with acute renal failure treated with peritoneal dialysis, 2 after renal transplantation. The antibiotic was given for local and generalised bacterial infections in 10 patients; in 15 the drug was administered prophylactically before serious surgical procedures (including 10 patients before renal transplantation). Resolution of infection was observed in 9 out of 10 treated patients (90%). When the antibiotic was given prophylactically, its efficacy was assessed as good in 8 of 10 patients (80%) after renal transplantation and in 4 of 5 patients (80%) after other surgical procedures. There were no significant adverse side effects in any patient. Biotrakson is, therefore, an effective drug for therapeutic and preventive use in patients with renal failure.
Pediatr Pol 1995 Dec
PMID:[Evaluation of the efficacy, tolerance and safety of Biotrakson use in patients with kidney failure]. 864 44

Development of dialysis methods and progress in kidney and pancreas transplantation allowed to treat an increasing number of patients suffering from diabetic nephropathy (D.N.). This report evaluates availability and results of treatment in these patients. 31.12.93 in Gdansk and Bydgoszcz area there were treated 519 patients, including 43 (8.2%) with D.N. It is impossible to evaluate the demand for renal replacement therapy in patients with D.N., because there is no exact data concerning diabetic patients with progressing renal failure. Up to now 88 patients with D.M. (68 with IDDM, 20 with NIDDM) were treat in this area. Most of them (92%) were treated with hemodialysis is and only a few with CAPD, 13 patients received a kidney graft. The average patient survival on dialysis treatment in NIDDM patients was 15 months and in IDDM patients was 11 months. Deaths were mainly caused by cardiovascular complications. The results of renal replacement therapy in these patients cannot be compared with data from other re ports, because the treatment was introduced at advanced stage of D.N. in patients with systemic complications (serum creatinine in IDDM was 9.7 md% and in NIDDM was 6.2% mg%). Following conclusions can be drawn from our observations: 1. There is a need for close cooperation between diabetologist and nephrologist in repeat of evaluation of the demand for renal replacement therapy and time for its institution in a particular patient. 2. The choice of method of renal replacement therapy depends on clinical findings in a particular patient but also on methods available in a particular center. 3. Improvement of therapy outcome can be achieved primarily by earlier institution of dialysis (serum creatinine below 5 m5%).
Pol Tyg Lek 1995 Sep
PMID:[Evaluation of acceptance rate and outcome of renal replacement therapy in patients with diabetic nephropathy--multicenter study]. 865 29

Case of 47 old women with progressive renal failure after chinese herbs and picture of renal interstitial fibrosis in the initial renal biopsy is presented. Pathogenic role of renal limited microscopic vasculitis is discussed on the basis of clinical outcome, high serum levels of p-ANCA as well as complete remission of the disease after long-term cyclophosphamide therapy.
Pol Arch Med Wewn 1996 Nov
PMID:[Nephropathy after use of Chinese herbs: rapidly progressive interstitial renal fibrosis or renal vasculitis?]. 909 58

Recently we have described a dependence of platelet disability in thrombosis upon the progression in renal failure and an elevated level of RGDS-containing degradation products in uremic plasma, which is also correlated with progression in renal failure. Based on fluorescence techniques, our present investigations concerned possible changes in platelet membrane fluidity and intraplatelet calcium homeostasis in uremic platelets. Washed platelets loaded with DPH or with Fura-2 were examined with LS-50 luminescence spectrometer. Light anisotropy of DPH measured at 37 degrees C was significantly higher in control platelet membranes than in uremic ones. It can be considered as more fluidic membranes of uremic platelets. No difference between the basal intraplatelet calcium level was found for uremic and control platelets, but in the presence of 5 mM EGTA, the basal level was reduced significantly deeper in uremic platelets. Activation of platelets by both ADP (12.5 microM) and thrombin (0.1 U/ml) resulted in rapid increase in the intraplatelet calcium level in the examined platelets, but this increase was significantly higher for control platelets. The results indicate an abnormal intracellular calcium homeostasis in uremic platelets, which is associated with an increased fluidity of platelet membranes in uremia.
Pol J Pharmacol
PMID:Platelet membrane fluidity and intraplatelet Ca2+ homeostasis are affected in uremia. 911 66


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