Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035078 (renal failure)
 31,970 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The examination was carried out in a group of 20 patients with decadent renal failure (14 males and 6 females) from 16 to 51 years of age (average 32 years) undergoing the therapy of repeated haemodialysis (HD) during a period from 1.5 to 72 months. The HD procedure was performed by the use of the cuprophan dialyze (Gambro). The samples were taken on an empty stomach, before HD and then in the 20th 60th and 120th minute of HD. The absolute number of lymphocytes and their subpopulations were determined by means of rosette tests. In the patients with uraemia, the absolute number of lymphocytes and their subpopulations in the peripheral blood was significantly lower than in healthy persons selected appropriately with respect to sex and age. In the initial phase of HD the authors found a significant decrease in the absolute number of the whole population of lymphocytes, and also their sub-populations T, B, TM and an increase in the absolute number of subpopulation TG. These changes were of transient character and became normalized almost completely in the 120th minute of the procedure.
Pol Arch Med Wewn 1989 Jun
PMID:[Changes in various lymphocyte subpopulations in the peripheral blood of patients with chronic uremia during hemodialysis]. 263 51

In rare cases of intestinal perforation in patients dialysed peritoneally may be the dialyzing catheter introduced into the peritoneal cavity for repeated use. The therapeutic procedure (conservative or operative) is the matter of dispute. The authors present a female patient, aged 62, undergoing intermittent peritoneal dialysis for terminal renal failure. The perforation of the transverse colon due to the dialyzing catheter was successfully treated conservatively: the catheter was removed, antibacterial drugs, parenteral nutrition and bedrest were administered. Uraemia was controlled by haemodialysis.
Pol Arch Med Wewn 1989 Jun
PMID:[Conservative treatment of perforation of the transverse colon caused by a catheter for continuous peritoneal dialysis. A case report]. 263 53

The study aimed at evaluating an incidence of the acquired cysts of the kidneys in children with chronic renal failure. The study involved 33 children with renal failure treated conservatively with continuous peritoneal dialysis under ambulatory conditions and hemodialyses. CT tomography and sonography were carried out in all patients. The acquired cysts of the kidney were diagnosed in one out of 33 examined patients (3.03%) by ultrasound. This result was confirmed by CT-scanning. It is worth following the development of the cyst in his child waiting for kidney transplantation and further following all dialysed patients with ultrasound performed once per three months and CT-scans in some patients.
Pol Tyg Lek 1989 Feb 27
PMID:[Acquired cysts of the kidneys in children with chronic renal failure]. 268 70

Ultrasound was used to measure echogenesis, renal cortex thickness and kidney length in 59 patients with various types of the primary glomerulonephritis. The obtained results have shown that the measured parameters correlated with the progress in renal failure. An increase in the intensity of echo from the cortex, thinning of the renal cortex, and the decrease in renal length are typical signs of the advancement of renal failure. As renal function deteriorates in the consequence of destruction of its parenchyma, ultrasound examination might be an illustration of the pathological changes in the kidney. Considering the fact that ultrasound is perfectly safe, it may be used in monitoring of the disease progress and the results of treatment.
Pol Tyg Lek
PMID:[Use of ultrasound for evaluating structural changes of the renal parenchyma in chronic primary glomerulopathies]. 270 94

The authors analysed perinatal mortality and the condition of 32 newborns of 30 pregnant women with a severe form of gestosis EPH, who did not react to therapy. In all the women the pregnancy was terminated prematurely between 29th and 37th week (not later than 7 days admission to hospital) because of threat to the fetus, threat to the pregnant woman due to renal failure or threat both to the fetus and the woman. In spite of the fact that the newborns had a lower birth weight in comparison with newborns born in the previous years, the above procedure led to the sixfold reduction of perinatal mortality. Fetal hypotrophia amounted to 43% and was ten times higher than in general population.
Ginekol Pol 1989 Apr
PMID:[Mortality of fetuses and newborns in gestosis EPH]. 280 79

Cytokines are a class of signal peptides which represent a major communication network in living organism. Over the last decade, the discovery, cloning and purification of hematopoietic cytokines (interleukins, hematopoietic growth factors) has increased our understanding of the regulation, proliferation, differentiation and function of hematopoietic cells. More recently, the large scale production of the recombinant forms of these molecules has enabled to treat the patients with pharmacologic doses of cytokines. The therapeutic activity of interferon-alpha (IFN-alpha) has been demonstrated in patients with chronic myeloid leukaemia and other chronic myeloproliferative syndromes. IFN-gamma is useful in the prevention of infections in patients with chronic granulomatous disease. Erythropoietin (EPO) was the first hematopoietic growth factor available for clinical use, initially to treat anaemia in renal failure patients. The next cytokines introduced into the clinic were granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF). They are used successfully in haematological malignant disorders to stimulate granulopoiesis after chemotherapy or bone marrow transplantation and to help mobilise marrow stem cells for peripheral blood stem cell transplantation. Interleukin (IL)-1, -2, -3, -4, -6 and -11 have been tested in clinical trials. However, the value of these agents remains to be established.
Acta Haematol Pol 1995
PMID:[Cytokines in the treatment of blood diseases]. 754 26

A case of a 38-year male patient treated for severe Wegener's granuloma has been presented. Immunosuppressive therapy including cyclophosphamide and prednisone produced a 4-week improvement followed by relapsed with advanced organ involvement (severe cardio-respiratory and renal failure). Intensive therapy with cyclosporine A and prednisone (given intravenously and next orally) carried out for 4 months produced a favourable response with complete regression of organ involvement. Actually, the patient is living in a complete remission since 4 years, and takes no drugs since 1 year.
Pol Tyg Lek
PMID:[A favorable result of immunosuppressive therapy combined with the use of cyclosporine in a case of particularly severe Wegener's granuloma]. 770 73

The disturbances of platelet function in end-stage renal failure varies in dialysed and non-dialysed patients. We examined some platelet function in 11 uremic patients treated conservatively (TC) and, again in the same patients, 3-month after the beginning of repeated hemodialysis treatment (HD). The blood samples were taken before hemodialysis. In TC patients normal platelet count, prolonged bleeding time, normal platelet aggregation, unchanged PF4 activity and decreased PF3 availability were shown, compared with control group. In HD patients also normal platelet count and prolonged bleeding time were noted, but increased platelet aggregation, increased PF4 activity and PF3 availability were observed, compared with control group and with TC patients. We conclude that in TC patients rather decreased platelet function was observed; after the beginning of hemodialysis treatment some platelet function became significantly enhanced, which suggests platelet activation. Moreover, in HD patients the disturbances of platelet function before dialysis were shown, then it is possible that platelet activation persists in interdialytic period.
Pol Arch Med Wewn 1994 Dec
PMID:[Change of platelet function after the beginning of repeated hemodialysis treatment in patients with uremia]. 771 51

A high rate of cardiovascular death in renal patients, particularly patients with endstage renal failure, has not been well appreciated in the past. It is obvious that cardiovascular lesions are more severe than can be explained by the classical risk factors of elevated blood pressure and dyslipidemia. In renal failure, a number of pathomechanisms are operative which may be paradigms of more general relevance, e.g. activation of the renin and sympathetic system, inhibition of the vasoconstrictor NO system, left ventricular hypertrophy in excess of what is expected for high blood pressure. A paradox inverse relation between lipid concentrations and cardiovascular death, i.e. a protective effect of hyperlipidemia, in dialysed patients, presumably results from the confounding effect of malnutrition, high lipid levels being a substitute marker of adequate nutrition.
Pol Arch Med Wewn 1994
PMID:Excess cardiovascular mortality in the uremic patient--what does it teach for other risk factors in the non-renal patient? 773 91

The effect was studied of blood pressure lowering treatment on renal failure and albuminuria (UAE) in patients with type I diabetes (IDDM) and imminent nephropathy as well as in patients with over diabetic nephropathy. The group of 24 patients with imminent nephropathy was subdivided: 1. twelve patients with borderline or overt hypertension with mean BP lowered not below 100 mmHg, and 2. twelve patients with BP within the normal limits, taking no hypotensive agents. In the other group of 12 patients with overt diabetic nephropathy hypertension was lowered below 105 mmHg and kept so for at least two years. All patients estimated their glycemia and glycosuria by themselves, ate 0.8 g protein/kg/24 h and about 100 mmol Na/24h. Under hospital conditions the following were estimated: albuminuria, glomerular filtration rate (51Cr EDTA) and effective renal blood flow (131I hippurate). The same examinations were repeated 1 year and 2 years later. The lowering of BP below 100 mmHg in patients with imminent diabetic nephropathy significantly lowered microalbuminuria without changing GFR, ERPF despite good or satisfactory compensation of diabetes. Maintaining BP below 105 mmHg for 2 years did not prevent the patients with overt nephropathy to develop progressive renal failure despite the rate of GFR deterioration and of the increase of albuminuria slowed down.
Pol Arch Med Wewn 1994
PMID:[Effect of treatment of arterial hypertension on renal function in patients with imminent and overt diabetic nephropathy]. 773 1


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