Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035078 (renal failure)
 31,970 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In our experience, MR has served largely as a problem-solving device, especially in those cases in which CT has proved equivocal. Magnetic resonance has been especially efficacious in evaluating cardiovascular pathology. Virtually the entire spectrum of aortic disease can be assessed accurately, making MR a reasonable alternative to CT or angiography in most cases. Indications for the use of MR in patients with thoracic neoplasia have also emerged. Magnetic resonance is more accurate than CT in assessing invasion of the chest wall and mediastinum. As a consequence, MR should be considered the imaging procedure of choice in patients with suspected Pancoast tumors. In some patients with lymphoma, MR can make a unique contribution by evaluating the response to therapy. Magnetic resonance also can be of value in assessing patients with signs of venous obstruction, especially when there is a contraindication to the use of intravenous contrast medium. Magnetic resonance is as accurate as CT in assessing most benign mediastinal pathology. The former study can easily differentiate atherosclerotic vessels or aneurysms from enlarged lymph nodes or masses, frequently obviating a more invasive study. It is especially efficacious in evaluating patients with cystic lesions, especially those with complex cysts not clearly of water density. In the hilum, MR can differentiate prominent hilar vessels from adenopathy or masses as reliably as CT. Again, in patients with renal failure or those who have documented allergies to iodinated contrast medium, MR should be the imaging procedure of choice to evaluate suspicious hila identified on plain chest radiographs. Magnetic resonance also can be used to differentiate central obstructing hilar tumors from peripheral collapsed lung. In certain cases, these findings may help determine resectability by demonstrating encasement of hilar and mediastinal vessels as well as the central airways. It should be anticipated that as technologic improvements continue to be made, MR will assume an increasingly important role in the imaging of thoracic disease.
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PMID:Thoracic magnetic resonance imaging. 200 44

Recently we have performed continuous hemofiltration (CHF) for the patients of acute renal failure after cardiovascular surgery. In this article, we discuss the effectiveness of CHF in the acute phase of renal failure after cardiovascular surgery compared with hemodialysis (HD). CHF group included 12 cases, and HD group included 19 cases. Two cases (16.7%) of CHF group and two cases (10.5%) of HD group were survived and discharged from hospital. Filtration volume of CHF (93.8 +/- 81.0 l) was significantly higher than that of HD (27.1 +/- 22.9 l), but filtration rate of CHF (410 +/- 87.4 ml/H) was significantly lower than that of HD (572 +/- 167 ml/H). Thus CHF removed excess water more gently and effectively than HD. Because the influence to the hemodynamics of CHF was much less than that of HD, we were able to start CHF (4.3 +/- 4.6 days after operation, BUN: 55.3 +/- 19.5 mg/dl), Cr: 3.95 +/- 0.63 mg/dl) significantly earlier than HD (7.8 +/- 4.1 days after operation, BUN: 113.1 +/- 29.4 mg/dl, Cr: 6.10 +/- 1.04 mg/dl). We needed high dose catecholamine or blood transfusion for the 11 cases (57.3%) of HD group during HD, but we needed them for only 1 case (8.3%) of CHF group. We concluded that CHF was safer and more useful than HD in the treatment of acute renal failure after cardiovascular surgery.
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PMID:[Continuous hemofiltration vs hemodialysis for the acute renal failure after cardiovascular surgery]. 202 1

The effect of the methylprednisolone (MP) pulse therapy on renal function was examined in 15 patients with renal or collagen disease. Three nephrotic patients who had reduced renal function and active renal disease with progressive deterioration of renal function prior to the use of MP developed transient renal failure following an MP pulse therapy. The renal failure in each case was reversed by discontinuation of MP and/or by forced diuresis using albumin and furosemide. We examined the correlations between the individual changes in serum creatinine (Scr), body weight (BW) and urine volume (UV) before and after the pulse therapy and other laboratory data such as Scr, total serum protein and albumin. There were significant correlations between a change in Scr on the one hand and changes in BW and UV, Scr and serum albumin on the other. These findings mean that the effect of the MP pulse therapy on renal function depends on the clinical state of the patient and that renal deterioration after the pulse therapy may be more marked in patients who are more nephrotic and more impaired in renal function and suggest that increasing sodium and water retention during an MP therapy and the associated renal interstitial edema, proposed as one of the mechanisms of acute renal failure occurring in patients with minimal-change nephrotic syndrome, may be responsible for the MP-induced transient renal failure.
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PMID:Effects of the methylprednisolone pulse therapy on renal function. 204 79

Vanadium (V) has been reported to inhibit a number of enzyme activities such as those of Na(+)-K(+)-ATPase. The main excretory pathway of this element is via the kidney. These facts led us to study the V distribution in uremic patients. As a result, hemodialysis patients at our dialysis center exhibited extremely high levels of serum V (23.9 +/- 11.3 ng/ml, n = 43) as compared with healthy adults. Nondialysis patients did not show increased serum V concentrations. The V contents were significantly elevated in the skin and in the aortae of hemodialysis patients. It was found that the tap water from Kanagawa prefecture, Japan, had the highest V concentrations among the 21 cities in Japan and the US. In conclusion, oral ingestion of V-contaminated water has likely caused an accumulation of the metal in patients with end-stage renal failure.
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PMID:Abnormal accumulation of vanadium in patients on chronic hemodialysis therapy. 207 94

In this preliminary study, water soluble contrast media (CM) were administrated to normal laboratory rats (n = 11) and renal function was monitored before and followed after this challenge. A significant decrease (p less than or equal to 0.001) of the absolute urinary creatinine output, was noted during 3 days after the injection of the CM: the median (M) control value was 0.0313 mumol/min. 100 g body weight (BW) (interquartile range (IR): 0.0014) while the M values the first, the second and the third day were 0.0209 mumol/min. 100 g BW (IR: 0.0141), 0.0198 mumol/min. 100 g BW (IR: 0.0044) and 0.0265 mumol/min. 100 g BW (IR: 0.0054) respectively. The serum creatinine 24 hours after injection was 59,8 mumol/l (IR: 7.92) which is significantly higher (p less than or equal to 0.002) compared to the M serum creatinine of 51.9 mumol/l (IR: 15.0) evaluated in a group of normal unchallenged laboratory rats. These changes are in contrast with the low frequency of renal failure episodes encountered in clinical circumstances. Further experiments with inclusion of a control group receiving a sham injection seem necessary.
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PMID:Evaluation of renal function before and after intravenous injection of non-cholangiographic water soluble contrast media in rats: preliminary results. 208 50

It has been suggested that sodium renal excretion is regulated, at least partially, by a factor with natriuretic properties called digoxin-like factor (DLF). As this substance crossreacts with digoxin antibodies, it was measured with a radioimmunoassay used to determine exogenous digoxin. Methodological conditions and quality control to determine DLF in plasma and urine have been established. Good correlation coefficients in specificity as well as dilution studies were obtained. Within--and between--assay coefficients of variations indicate good reproducibility. Moreover, changes in plasma DLF levels were detected in patients with cirrhosis or with renal failure, diseases which thrive on alterations in salt and water metabolism. In conclusion, this radioimmunoassay method for measuring DLF may be useful to investigate the role of this factor in several physiological and pathological conditions.
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PMID:[Developement and quality control of a radioimmunoassay for measurement of endogenous digoxin]. 209 36

Mannitol is widely used to reduce intracranial pressure and is protective against ischemic and nephrotoxic acute renal failure. However, the capacity of this seemingly innocuous agent to produce acute renal failure is not well recognized. We report herein the clinical course of 8 cases of mannitol-induced acute renal failure. In addition, we reviewed all previously reported cases of mannitol-induced renal failure. In the present series, acute oliguric renal failure developed within 3.5 +/- 1.1 (mean +/- SD) days after receiving daily and total mannitol doses of 189 +/- 64 g and 626 +/- 270 g, respectively, over 3.5 +/- 1.5 days. The peak serum creatinine was 5.7 +/- 2.7 mg/dl and peak osmolal gap was 74 +/- 39 mOsm/kg water. Renal tubular epithelial cells containing vacuoles were seen in the urinary sediments of 6 patients. Renal function improved rapidly upon discontinuation of mannitol and/or removal of mannitol by hemodialysis. In those previously reported cases in which the baseline renal function was normal, acute renal failure developed after receiving total mannitol doses of 1171 +/- 376 g. The peak osmolal gap was 107 +/- 17. In contrast, in those with underlying renal compromise, renal function worsened after a total mannitol dose of 295 +/- 143 g. The pathogenesis of mannitol-induced renal failure is not yet established but may be associated with renal vasoconstriction produced by high concentrations of mannitol. This may be averted in clinical practice by monitoring the osmolal gap, rather than serum osmolality alone, when using mannitol infusions for the treatment of intracranial hypertension.
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PMID:Mannitol-induced acute renal failure. 211 70

Thirty-six patients with preoperative renal dysfunction were studied to evaluate the effects of dopamine (D) and dopamine-nitroprusside (DN) on renal function during cardiopulmonary bypass (CPB). No differences from the control group (C) were found in creatinine clearance, fractional sodium excretion, osmolarity and free-water clearance. Sodium output/intake ratio during CPB was higher in group D than in groups C and DN (P less than 0.05); water output/intake ratio was higher in group D than in group C (P less than 0.05). Urine lysozime levels and alpha-glycosidase/creatinine ratios increased similarly in the three groups, suggesting ischemic tubular cell damage. No patients showed acute postoperative renal failure or a worsening of their renal dysfunction. The data suggest an increased water and sodium excretion during CPB with a dopamine infusion, possibly resulting from a renal vasodilator effect that was abolished by simultaneous nitroprusside administration.
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PMID:Low-dose dopamine during cardiopulmonary bypass in patients with renal dysfunction. 213 43

1. The natriuretic and diuretic effects of atriopeptin III (125, 250 and 500 ng kg-1, i.v.) were studied in groups of rats anaesthetized with pentobarbitone which were either sham controls, unilaterally nephrectomized controls, adenine-fed or subtotal nephrectomy chronic renal failure models. 2. Atriopeptin III given at these doses to the sham control animals had no effect on blood pressure, renal blood flow or glomerular filtration rate but reversibly increased urine flow, between 46% to 54%, absolute sodium excretion, between 52% to 61%, and fractional sodium excretion, between 48% to 54% (all P values less than 0.05) from the lowest to the highest dose. The adenine-fed chronic renal failure group of rats had a reduced renal blood flow of between 30 and 75%, and glomerular filtration rate of approximately 20%, compared to the sham controls. Administration of atriopeptin at 125, 250 and 500 ng kg-1 to the animals with renal failure increased water and sodium excretion to the same degree as observed in the sham group of rats. 3. In the group of unilaterally nephrectomized rats, atriopeptin III, at 125, 250 and 500 ng kg-1 increased urine flow by 36%, 47% and 72%, respectively, absolute sodium excretion by 37%, 57% and 106%, respectively, and fractional sodium excretion by 46%, 45% and 102%, respectively. A similar pattern of responses was observed in the subtotal nephrectomy, chronic renal failure group in which filtration rate was approximately 4 times less than the controls. 4. These results show that in two different models of chronic renal failure, atriopeptin III still caused a natriuresis and diuresis. This suggests that the nephrons retain sensitivity to the atrial natriuretic peptides in diseases such as chronic renal failure and that these compounds may be useful in mobilizing body fluids in this situation.
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PMID:The action of atriopeptin III on renal function in two models of chronic renal failure in the rat. 213 50

Since it remains unclear how the regulatory mechanism of blood pressure and volume is associated with the renin-angiotensin system, the sympathetic nervous system, and atrial natriuretic peptide (ANP), we examined the changes in blood pressure and vasoactive hormones occurring in 12 patients with end-stage renal failure. They were divided into two groups, those who were anuric (group A, n = 7), and those who had a daily urine volume of more than 700 ml (group B, n = 5). The changes in the mean blood pressure (MBP) and these vasoactive hormones were observed during hemodialysis with water removal in group A and without water removal in group B, and during blood pressure reduction with sodium nitroprusside in group A. The basal levels of ANP in groups A and B were twice as high as those of normotensive subjects. During hemodialysis, MBP did not reveal any changes in both groups. In group A, ANP and body weight (BW) decreased, whereas the plasma renin activity (PRA) and norepinephrine (NE) increased. In group B, ANP remained stable during the first 3 hr and decreased at the end of hemodialysis. However, BW, PRA, and NE were unchanged. In group A, significant correlations were observed between the changes in BW and those in ANP (r = 0.52, p less than 0.05), PRA (r = -0.57, p less than 0.01), and NE (r = -0.76, p less than 0.01). During blood pressure reduction, MBP decreased with accompanying increases in NE and PRA. However, ANP did not show any change.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Interrelationships among the renin-angiotensin system, sympathetic nervous system and atrial natriuretic peptide in end-stage renal failure. 214 72


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