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Enzyme
Compound
Pivot Concepts:
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Target Concepts:
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Query: UMLS:C0034186 (
pyelonephritis
)
6,144
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Percutaneous nephrostomy (PCN) catheters are the primary method for draining ureters obstructed by malignancy and preventing a decline of renal function. However, PCN catheter-related infections, such as
pyelonephritis
and urosepsis, remain a significant concern. Currently, no antimicrobial PCN catheters are available for preventing infection complications. Vascular catheters impregnated with minocycline-rifampin (M/R) and M/R with chlorhexidine coating (M/R plus
CHD
) have previously demonstrated antimicrobial activity. Therefore, in this study, we examined whether these combinations could be applied to PCN catheters and effectively inhibit biofilm formation by common uropathogens. An
in vitro
biofilm colonization model was used to assess the antimicrobial efficacy of M/R and M/R-plus-
CHD
PCN catheters against nine common multidrug-resistant Gram-positive and Gram-negative uropathogens as well as
Candida glabrata
and
Candida albicans
Experimental catheters were also assessed for durability of antimicrobial activity for up 3 weeks. PCN catheters coated with M/R plus
CHD
completely inhibited biofilm formation for up to 3 weeks for all the organisms tested. The reduction in colonization compared to uncoated PCN catheters was significant for all Gram-positive, Gram-negative, and fungal organisms (
P
< 0.05). M/R-plus-
CHD
PCN catheters also produced significant reductions in biofilm colonization relative to M/R PCN catheters for
Enterobacter
spp.,
Escherichia coli
,
Pseudomonas aeruginosa
, methicillin-resistant
Staphylococcus aureus
, vancomycin-resistant enterococci,
C. glabrata
, and
C. albicans
(
P
< 0.05). M/R-plus-
CHD
PCN catheters proved to be highly efficacious in preventing biofilm colonization when exposed to multidrug-resistant pathogens common in PCN catheter-associated
pyelonephritis
. M/R-plus-
CHD
PCN catheters warrant evaluation in a clinical setting to assess their ability to prevent clinically relevant nephrostomy infections.
...
PMID:
In Vitro
Study of Antimicrobial Percutaneous Nephrostomy Catheters for Prevention of Renal Infections. 2832 Jul 13
