Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034186 (
pyelonephritis
)
6,144
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Nicotinamide phosphoribosyltransferase
(
NAMPT
) was first reported in 1994 and has been explored in various human disease processes. However, until recently, very little has been done to define the role of
NAMPT
in pregnancy.
NAMPT
is a 52 kDa protein that has diverse functions in the human body, acting as a growth factor, cytokine, an enzyme, and an insulinomimetic agent. Initial studies examined
NAMPT
expression in fetal membranes and its effects on the amnion. Later research in nonpregnant studies showed an insulinomimetic effect, and attention focused on its role in gestational diabetes. In addition, as studies revealed
NAMPT
's function as an inflammatory cytokine, studies examined
NAMPT
in preeclampsia and fetal growth restriction. Several studies have confirmed that
NAMPT
is a marker of systemic infectious processes such as
pyelonephritis
and intrauterine infection. In this review, we present the current understanding of
NAMPT
's role in various pregnancy-related conditions as well as possible directions for future research.
...
PMID:The Role of Nicotinamide Phosphoribosyltransferase in Pregnancy: A Review. 2713 57
