Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study belongs to a series of comparative biochemical and semiquantitative-histological investigations in renal tissue fractions of pyelonephritis patients (human PN) and of different types of experimental pyelonephritis (experimental PN). The experiments aim at more detailed knowledge on the interrelationship of intermediary cell metabolism and histopathological changes during the different phases of human and experimental PN. The results concerning acid and alkaline phosphatase activities as well as concerning glutaminase I and glutamic dehydrogenase activities were earlier reported (Exp. Path. vols. 8, 9, 10 and 12). In the present study the author has analyzed the activities of aspartate aminotransferase (E.C.2.6.1.1. AspAT) the synonym of which is glutamic oxaloacetic transaminase (GOT).
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PMID:[Aspartate aminotransferase activities in renal tissue during experimental and human chronic pyelonephritis]. 92 89

Enzyme levels of lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (HBDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured in the cytosol of renal cortex samples from either normal and pathologic kidney tissue. The mean enzyme activity values, expressed in Units per gram of cytosolic protein decreased in the following order: normal cortex (LDH = 4,299 +/- 654; AST = 522 +/- 101; ALT = 197 +/- 44). chronic pyelonephritis (LDH = 2,360 +/- 876; AST = 297 +/- 117; ALT = 90 +/- 48), hydronephrosis (LDH = 2,208 +/- 1,264; AST = 279 +/- 165; ALT = 82 +/- 61), pyonephrosis (LDH = 1,410 +/- 596; AST = 158 +/- 69; ALT = 23.4 +/- 16.4) and renal tuberculosis (LDH = 1,149 +/- 481; AST = 93 +/- 34; ALT = 5.6 +/- 2.8). The decrease in the enzyme activities paralleled tissue damage and it was shown to affect cellular functionality in relation with energy and amino acid metabolism.
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PMID:Cytoplasmic enzyme activities involved in energy and amino acid metabolism in pathological human renal cortex. 324 90

Thirty children with urinary tract infection and nonobstructive vesicoureteral reflux have been followed prospectively for a mean of 17 months. After classification according to age and grade of reflux, 10 patients were assigned at random to treatment with antimicrobial prophylaxis alone or antimicrobial prophylaxis plus corrective surgery. Twenty other patients were also treated with antimicrobial prophylaxis alone. All were assigned at random to treatment with a single daily dose of trimethoprim-sulfamethoxazole or nitrofurantoin. Cultures of urine, complete blood cell counts, and determination of levels of aspartate aminotransferase in serum were performed regularly during follow-up. Both drugs proved effective in prevention of recurrent infection, and no significant hematologic or hepatic abnormalities were noted. Current results suggest that either prophylaxis or surgery may effectively prevent chronic pyelonephritis or reflux nephropathy, but only continuing evaluation of this group of patients will confirm these results.
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PMID:Antimicrobial prophylaxis in children with urinary tract infection and vesicoureteral reflux. 698 Nov 65