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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study was made (in vitro) of the interaction of various strains of E. coli, serological type O26 with continuous human cells (HeLa, Tg-33 and RH). Phenomenon of the cytopathogenic action of uropathogenic E. coli strains, containing heterogenous antigens, type O(H) and B, on the human cell strains possessing corresponding isoantigens was revealed on the 6th hour of the interaction. The number of dead cells in these cultures exceeded (1.5--3 times) their count cultures to which E. coli containing no heterogenous antigens or containing different human heterogenous antigens of the ABO type were added. It is supposed that this phenomenon played an important role in the development of chronic forms of colibacterial pyelonephritis.
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PMID:[Cytopathogenic action of E. coli strains, containing corresponding ABO type heterogeneous antigens, on transplantable human cells]. 77 67

280 patients of a centre of nephrology were with regard to their distribution of ABO and rhesus blood groups compared with a control group consisting of 4,089 donors. Female patients with pyelonephritis showed with a probability of error of less than 5% more frequently the blood group A (56.7 vs 41.8%) and more infrequently the blood group 0 (20.0 vs 39.9%). The increase of frequency of female patients of the blood group B with cystic kidneys (30.0 vs 12.6%) reached the significance level of p less than 0.1.
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PMID:[ABO blood groups in patients with nephropathies]. 206 45

Best possible tissue compatibility is a fundamental precondition for a successful organ transplantation. The desirable tissue compatibility is mainly defined by transplantation-antigens of the donor and the recipient and therefore--beside ABO antigens--the characteristics of HLA-system are the focal point of the preoperative immunological diagnosis. Based on the results of comperative examinations it is demonstrated, that HLA-antisera have such a widespread biological variability, that they lead sometimes to a faulty diagnosis which in turn causes the biological importance of the HLA-system to be doubted. The preoperative immunologic diagnosis should include an estimation of the risk factors in the patient. The consideration of the crossmatch between donor and recipient is a decisive factor in organ transplantation. The starting point is the preoperative antibody monitoring which checks the patients serum reactions against a panel of blood donors to see, whether the patient is a "high" or "low"-- responder to allogenetic stimuli. A positive reaction in the crossmatch is brought about by different kinds of antibodies whereby only in the presence of auto-antibody or cold-reactive B-cell antibody a transplantation may take place. The antibody characterisation in preoperative diagnosis is supported by the results of the immunologic antibody monitoring, whereby--because of the results here presented-- it can be confirmed, that through the knowledge of the antibody specifities which have been checked in a positive crossmatch transplantation on highly sensitized patients can take place with a prospect of success. Supplementing the "Eurotransplant" results the HLA-DRw6 antigen is shown not only to be an indication of risk in transplantation, but may also be an aetiopathogenetic factor. In the presentated statistics it can be shown, that in patients suffering from glomerulonephritis or pyelonephritis and requiring dialysis treatment the HLA - DRw6 antigen occur more frequently than in the control group of healthy blood donors. In glomerulonephritis patients there is additionally a significant change in distribution favourable to HLA - DRw10 shown. The determination of genetically caused risk factors is appreciably supported by characterisation of lymphocyte subpopulations and diagnosis of changes in the Complement-system. Changes in T-lymphocyte subpopulations pointing to proceedings of immunostimulation and conditions of the activated Complement-system represent warning signals in organ transplantation.
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PMID:[Immunologic and transplantation biology studies in patients with terminal renal failure]. 389 33

Analysis of 140 strains of E. coli isolated from patients with pyelonephritis has demonstrated heterogeneous antigens (in 44.3% of cases) related to ABO antigens against human red blood cells. 0(H)-like antigen occurred most frequently. The data obtained suggest that the presence of heterogeneous antigens in E. coli is associated with the formation of a latent subclinical form of pyelonephritis and with the decrease titers of antibacterial antibodies in patients.
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PMID:[Immunobiologic study of the role of heterogenetic antigens of uropathogenic strains of E. coli]. 702 68

Six cases of combined heart and kidney transplantation with organs from the same donor are reported. All six patients suffered from primary end-stage kidney disease, two chronic glomerulonephritis, two glomerulosclerosis, one chronic pyelonephritis and one with unknown etiology. Four patients were undergoing hemodialysis. Three patients had the diagnosis of ischemic heart disease, one dilated cardiomyopathy secondary to congenital heart disease, two idiopathic dilated cardiomyopathy. Five were males and one female. Ages ranged from 38 to 54 years. On-site or short-distance young donors with normal renal function and good cardiac function necessitating low inotropic support were selected. ABO compatibility was used exclusively. Orthotopic heart transplantation was performed first. During cardiopulmonary bypass, hemofiltration was used in four cases. Kidney transplantation was performed immediately after the closure of the chest. Diuresis was immediate in all cases. No cardiac rejection was documented at EMB. Renal function normalized within few days with no signs of kidney rejection. All six patients are alive and well with normal cardiac and renal function at a mean follow-up of 43 months. Patients and donors selection associated with a proper surgical strategy and prompt immunosuppressive therapy administration make the combined heart and kidney transplantation an effective therapeutic option.
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PMID:Combined heart and kidney transplantation: an effective therapeutic option--report of six cases. 937 Apr 13