Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Blood serum levels of stage-specific antigens were measured by radioimmunoassay and immunodiffusion methods in patients with acute pyelonephritis at various stages of traditional antibacterial therapy and ultraviolet autoblood irradiation. Under study were ferritin, beta 2-microglobulin, C-reactive protein, transferrin, alpha 2-macroglobulin, and haptoglobin levels. Kinetics of the measured proteins was demonstrated and the possibility of applying their identification to assessment of treatment efficacy shown. The levels of these proteins are shown to be not only indicators of inflammation and destruction in pyelonephritis, but to reflect as well the repair reactions in the body which course most actively when UV irradiation of autoblood is added to multiple-modality treatment schemes.
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PMID:[Serum antigens in the evaluation of the effectiveness of pyelonephritis therapy]. 795 3

A 64 year old woman had been receiving haemodialysis for 11 years. She had a history of chronic renal failure, caused by probable chronic pyelonephritis, and dialysis arthropathy. She died of acute pulmonary oedema and haemorrhage. At necropsy, histological, immunohistochemical, and ultrastructural studies showed widespread visceral deposits of beta 2-microglobulin (beta 2-M) and AA amyloid.
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PMID:Mixed systemic amyloidosis in a patient receiving long term haemodialysis. 806 44

The study aimed at evaluating the proximal tubule function in patients with active metabolic urolithiasis with the assay of beta 2-microglobulin in the urine. The studies involved 30 patients with urolithiasis associated with chronic pyelonephritis and 31 patients with urolithiasis without pyelonephritis. Fifty healthy individuals served as a control group. Serum and urine beta 2-microglobulin concentrations were assayed with radioimmunological technique in all persons. Clearance of this microglobulin and tubular reabsorption were calculated. It was found that beta 2-microglobulin excretion with the urine is significantly higher in patients with metabolically active urolithiasis accompanied by the chronic pyelonephritis. beta 2-microglobulin clearance was significantly higher and tubular reabsorption significantly lower than those in patients without pyelonephritis and in control group. These finding suggest a dysfunction of the proximal tubule in patients with urolithiasis produced by the chronic inflammatory process in the urinary system. Negative correlation between blood serum beta 2-microglobulin levels and creatinine clearance was shown. Therefore, serum beta 2-microglobulin concentrations may be of value in evaluation of the glomerular filtration rate.
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PMID:[Usefulness of determining beta-2-microglobulin in serum and urine in patients with metabolically active kidney calculi and healthy individuals]. 817 Aug 11

The authors present the effect of intravenous He-Ne laser therapy on the changes in beta 2-microglobulin, lipid peroxidation, middle-size molecules in the blood and urine of patients with acute calculous pyelonephritis. Endovascular He-Ne laser therapy was found an effective treatment of acute calculous pyelonephritis. The authors propose to combine hemosorption with endovascular He-Ne laser radiation.
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PMID:[The dynamic level of beta 2-microglobulin, the basic lipid peroxidation indices and middle molecules in the blood and urine in patients with acute calculous pyelonephritis against a background of endovascular helium-neon laser therapy]. 912 56


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