Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

180 renal transplants have been performed at our center in children less than 15 years old. Even if the distribution is equivalent (50/50%) between kidneys from living and cadaver donors, graft actuarial survival rate is 20% better at 5 years in the first group. 42 grafts have been implanted for end-stage renal failure due to chronic pyelonephritis (CNP). Among them, 17 were due to obstructive L.U.T. uropathies (posterior urethral valves): even if the results are identical in that subgroup compared to CPN group, there is an increased morbidity risk as 2 ureterovesical stenosis and 1 secondary vesico-ureteral reflux were observed (3/17 versus 4/163 in the remnant population).
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PMID:[Results of renal transplantation in children with obstructive uropathy due to malformations]. 237 39

The antiinflammatory cytokines participate in antiinfective immunity, that is why it is advisable to study their peculiarities in determination of the role in immunologic pathogenesis of pyelonephritis. Of the work is to study the levels of pro-inflammatory blood cytokines in the patients with pyelonephritis (PN), to determine the peculiarities in acute and chronic its course in children and adults. The immuno-enzymic method ELISA and the corresponding test-systems were used to study the levels of cytokines in blood. There were studied the levels of pro-inflammatory cytokines (TNF, MCP and IL-23) in blood serum of patients with acute (APN) and chronic (CPN) pyelonephritis. The analysis showed the reliable increase in levels of all studied findings in both forms of PN--both in all 173 patients and in every group--children (87) and adults (86). The MCP-1 levels in APN are reliably higher than in CPN, while in TNF-b and IL-23--do not differ. The levels of all three cytokines in blood of adults were higher than in children in APN, but TNF--in CPN as well. The high level of TNF, MCP-1 and IL-23 in blood of adults and children confirm their important role both in APN and CPN, but MCP-1 can be considered as a predictor of acute/exacerbation of chronic pyelonephritis. By the findings of the studied cytokines, more expressed immune response was noted in the adults.
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PMID:[Proinflammatory cytokines in patients with pyelonephritis]. 2551 86