Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Repetitive topical applications of 2 micrograms 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly for 37 to 52 weeks induced a sustained epidermal hyperplasia, hyperplasia of hair follicles, and increased dermal cellularity in SENCAR mice. In addition, after 52 weeks of protracted promoter treatment most animals developed generalized amyloidosis involving liver and spleen, as well as interstitial nephritis. Severe pyelonephritis and papillary necrosis were also frequently seen. Reactive lymphoid hyperplasia was also a frequent finding. Chronic administration of TPA is not an innocuous treatment affecting only the interfollicular epidermis. The general effect of the promoter on the animals was a marked decrease in their longevity, probably through impairment of the immune system.
Environ Health Perspect 1986 Sep
PMID:Effects of chronic topical application of 12-O-tetradecanoylphorbol-13-acetate on the skin and internal organs of SENCAR mice. 378 Jun 35

Altogether 68 patients were examined in early and late periods after operations on the kidneys. Function of the operated kidney was checked up by the results of two-indicator renal scintigraphy with 99mTc-DTPA and 131I-hippuran. When the kidney preserved its secretory capability and the suppression of organ function was caused by inhibited urine passage via the upper urinary tract, therapy aimed at the restoration of the kidney integrity and the elimination of the urine discharge obstruction, resulted in a rapid and complete recovery of all renal functions. Operative treatment of prolonged urological diseases complicated by chronic pyelonephritis, helped to accelerate secretory-excretory processes and slightly improved function of unchanged nephrons. A progressive decrease in the actively functioning parenchyma was recorded on scintigrams in 28% of the cases of the formation of the arteriosclerotic kidney. The authors found radionuclide investigations appropriate in the postoperative period not only in the development of complications and recurrences of urological diseases. Two-indicator renal scintigraphy with glomerulotropic and tubulotropic radiopharmaceuticals made it possible to give an objective assessment of the efficacy of surgical intervention.
Med Radiol (Mosk) 1985 Sep
PMID:[Radionuclide evaluation of the function of the operated kidneys]. 390 Jun 21

A new human gamma-globulin for intravenous use, SM-4300, was administered to 13 patients with infectious diseases. Five grams of SM-4300 was drip infused to each patient whose infection was not controlled by previous administered antibiotics. All of 13 patients had primary diseases besides infections. Thirteen patients were composed of 4 with pyelonephritis, 2 with pneumonia, 1 with bronchopneumonia, 1 with bronchitis, 1 with pyothorax, 2 with sepsis and 2 with cholecystitis. The results obtained were good in 3 cases, fair in 2 cases and poor in 7 cases. The results of a patient was not determined. No side effect was found including in laboratory findings.
Jpn J Antibiot 1985 Sep
PMID:[Clinical study on SM-4300 in the field of internal medicine]. 393 25

Initial antibiotic therapy should be based on Gram's stained urine. For the elderly patient with acute symptomatic bacterial pyelonephritis caused by gram-negative aerobic bacilli, an aminoglycoside is recommended, eg, gentamicin, tobramycin, or amikacin. Pathologic pyuria (greater than 10 WBC/high-power field) supports the clinical impression of acute symptomatic bacterial pyelonephritis. However, many factors can spuriously lower the number of bacteria in the urine: prior diuresis or antimicrobials; obstruction distal to the site of infection; and infection not directly accessible to the collecting system.
Geriatrics 1985 Sep
PMID:Diagnosing a common kidney infection of the elderly inpatient. 402 24

A pregnant woman allergic to penicillin was successfully treated with erythromycin for pyelonephritis and bacteremia caused by Lactobacillus.
South Med J 1985 Sep
PMID:Lactobacillemia in pregnancy. 403 43

Emphysematous renal infection is a severe, rare complication of urinary tract infection associated with gas production, which frequently causes renal destruction and has a high mortality rate. It is termed emphysematous pyelitis when gas is confined to the collecting system, or emphysematous pyelonephritis if it also involves the parenchyma with or without the perirenal space. Only 7 cases of perirenal emphysema have been described previously; all were in diabetics. Here we present a rare case of gas-producing renal infection in the collecting system and perirenal tissues, in a nondiabetic patient, and discuss the management of the various types of emphysematous renal infections.
Urology 1985 Sep
PMID:Emphysematous renal and perirenal infection in nondiabetic patient. 403 53

A study of 133 necropsies on leprosy patients showed that renal disease, pyogenic infections, and tuberculosis were the most frequent causes of death. Major kidney lesions encountered included glomerulonephritis of different types, pyemic abscess, acute tubercular necrosis, amyloidosis, and chronic pyelonephritis. In many cases the renal lesions were secondary to infections in other organs. Case control studies are required to determine if the high prevalence of these diseases is related to leprosy, its complications, or its therapy, per se, or if it is a reflection of the disadvantaged and poor socioeconomic status of these patients.
Int J Lepr Other Mycobact Dis 1985 Sep
PMID:Renal lesions and other major findings in necropsies of 133 patients with leprosy. 404 64

The results of urethrocystography in 193 patients with urodynamically and clinically confirmed recurrent incontinence were analyzed. Severe displacement of the vesical cervix and the proximal section of the urethra predisposes the patient to recurrent stress incontinence. The roentgenological findings (difference of over 30 mm in the distance between the vesical cervix and the ischium, outflow of contrast medium next to the catheter under stress with differential values between 20 and 40 mm, angle of inclination of the proximal urethra of over 45 degrees) are significantly more frequent in cases of recurrent stress incontinence than in cases of first occurrence (132 patients). Of the 193 patients 164 (84%) had previously undergone a vaginal operation. In 60% of these 164 patients the difference in the distance between the vesical cervix and the ischium was 30 mm or more under "resting" stress, and in a further 19% it was between 26 and 30 mm, often with outflow of contrast medium during "pressing". Stress incontinence has a damaging effect on the supporting apparatus of the urethra and the bladder, and also on the ureter and the kidneys. Ureteral drainage disorders and chronic pyelonephritis are the changes most commonly diagnosed in roentgenograms. No statistically significant differences between recurrent and first-time stress incontinence were found. Urethrocystographic findings facilitate selection of the surgical procedure. It appears possible to reduce the frequency of recurrence if preoperative roentgenological findings are taken into account.
Geburtshilfe Frauenheilkd 1985 Sep
PMID:[Recurrent stress incontinence]. 405 46

The role of the renal papillae in the pathogenesis of pyelonephritis and reflux nephropathy was studied by endoscopy and histology in adult autopsy kidneys. Compound papillae with a concave area cribrosa of the "reflux type" were found in greater frequency in adults than in children. Acute purulent inflammation in the renal parenchyma or coarse pyelonephritic scars were seen almost always overlying "refluxing" papillae or overlying papillae altered by papillary necrosis, obstructive atrophy and other changes of papillary shape. Intrapapillary tubular obstruction in early analgesic nephropathy, gout, myeloma and medullary cystic disease is an other factor favouring bacterial infection to occur. Without an underlying renal papillary damage renal injury attributable to urinary infection seems to be rare.
Klin Wochenschr 1985 Sep 16
PMID:[Significance of kidney papillae in the pathogenesis of pyelonephritis and reflux nephropathy]. 405 18

Prospective trials of surgical versus nonsurgical treatment in children with nonobstructive vesico-ureteral reflux and urinary tract infection are referred. Available data do not yet document significant differences of frequency of urinary tract infections, of morphological and functional renal damage, and of blood pressure under the conflicting treatment regimens. The frequency of acute pyelonephritis seems to decrease after surgical reflux resolution beyond the first postoperative weeks. Ongoing two studies are promising future scientific rather than present biased basis for individual therapeutic decisions after further increase of patient numbers resp. further accumulation of observation time.
Klin Wochenschr 1985 Sep 16
PMID:[Prospective alternating comparisons of the operative and nonoperative treatment of vesico-renal reflux]. 405 20


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