Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study, serum total (TC), free (FC), and acyl (AC) carnitine levels were investigated in 20 healthy controls (13 males and 7 females) and 27 patients (10 males and 17 females) with chronic pyelonephritis (CPN) undergoing regular chronic hemodialysis (CHD). The results showed that CHD treatment in CPN patients displays significantly decreased serum L-carnitine levels. The mean predialysis serum TC, FC, and AC (48 +/- 8, 42 +/- 6.3 and 13 +/- 2.7 nmol/ml, respectively) were not significantly different from the mean healthy control serum TC, FC and AC (50 +/- 7.1, 46 +/- 6.1 and 10 +/- 2.1 nmol/ml, respectively) (p < 0.1). However, after CHD, a significant decrease in serum TC, FC and AC levels (21.2 +/- 4.2, 17.1 +/- 3.1 and 6.1 +/- 2.4 nmol/ml, respectively) was observed compared to the values in both predialysis (48 +/- 8, 42 +/- 6.3 and 13 +/- 2.7 nmol/ ml, respectively) and healthy controls (50 +/- 7.1, 46 +/- 6.1 and 10 +/- 2.1 nmol/ml, respectively), (p < 0.001). Serum TC, FC and AC levels of male (49 +/- 5.5, 44 +/- 6.1 and 9.5 +/- 2.1 nmol/ml, respectively) and female (47.8 +/- 6.2, 38.5 +/- 9.3 and 9.7 +/- 2.3 nmol/l, respectively) healthy controls, and male (45.6 +/- 6.7, 44.1 +/- 5.1 and 12.3 +/- 1.5 nmol/ml, respectively) and female (46 +/- 5.1, 39 +/- 5.7 and 11.7 +/- 2.2 nmol/ml, respectively) predialysis patients showed no significant difference (p < 0.1). However, after CHD, serum TC, FC and AC levels of male (22.5 +/- 2.7, 16.8 +/- 3.9 and 5.1 +/- 2.1 nmol/ml, respectively) and female (19.5 +/- 2.4, 15.2 +/- 1.41 and 5.7 +/- 2.7 nmol/ml, respectively) patients were significantly decreased, compared with predialysis values (p < 0.001). After CHD, the ratio of serum AC to FC (0.47 +/- 0.03) was significantly increased compared with both healthy controls (0.3 +/- 0.03) and predialysis patients (0.32 +/- 0.03) (p < 0.001 and p < 0.01, respectively). Comparatively, the ratio of serum AC to FC was increased significantly after CHD (males, 0.45 +/- 0.02 and females, 0.41 +/- 0.03) when compared with both gender healthy controls (males, 0.29 +/- 0.052 and females, 0.26 +/- 0.033) and both gender predialysis patients (males, 0.33 +/- 0.02 and females 0.28 +/- 0.01), (p < 0.001). A possible physiological consequence of this finding remains unclear.
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PMID:Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. 907 96

Pyelonephritis is an inflammatory process, and oxidative stress plays a major role in it. Anti-inflammatory or antioxidant therapy given concomitantly with antibiotics should lower the risk of postpyelonephritic scarring. As the lack of review studies in the use of antioxidants in urinary tract infections was detected, this study was designed. We conducted a review of available articles in PubMed and Google Scholar with a simple review, using keywords of "antioxidant" and "pyelonephritis" with all their possible synonyms and combinations. Only interventional studies were collected. There were neither limitations on time, nor the location of the study, type of subjects, administration rout of the antioxidant drug, and the antioxidant drug used. After studying the abstracts or in some cases the full text of articles, they were categorized based on the type of antioxidant, type and number of subjects, rout of administration, dosing, duration of treatment, year of publication of the paper, and the results. A total of 66 articles published from 1991 to 2015 were found by studying just the title of the papers. Studying the abstracts reduced this number to 51 studies. Antioxidants used for this condition were Vitamins A, E, and C, cytoflavin, caffeic acid phenethyl ester, ebselen, allopurinol, melatonin, N-acetylcysteine, oleuropein, montelukast, oxytocin, ozon, dapsone, pentoxifyllin, tadalafil, bilirubin, cranberry, meloxicam, L-carnitine, colchicine, perfluoran, methylprednisolone, and dexamethasone. Studies show that antioxidants are capable of reducing oxidative stress and can be used effectively along with antibiotics to reduce the scar formation.
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PMID:Use of antioxidants in urinary tract infection. 2716