Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A review of the literature on sickle cell trait was completed by Sears in 1978. Since that time, several papers have been published concerning the possible health risks of sickle cell trait. Data presented from these studies show that there is no association with sickle cell trait and overall survival, overall mortality, overall morbidity, frequency and length of hospitalization, short-term survival of renal transplant recipient, and inheritance of glucose-6-phosphate dehydrogenase. Association with sickle cell trait is very likely in the following: splenic infarction at high altitudes (over 10,000 feet), in unpressurized airplane flight and mountain climbing, bacteriuria and pyelonephritis in pregnancy, hyposthenuria, hematuria, and delayed resolution of anterior chamber hyphema. Although these conditions have a statistical significant association with sickle cell trait, they occur quite infrequently. Thus, when they are observed, other causes should be sought before attributing them to sickle cell trait. Reduced mortality from Plasmodium falciparum infection also shows significant association with sickle cell trait.
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PMID:Sickle cell trait: an update. 675 30

Circadian dynamics of ferritin, serum iron, and MDA concentrations, ineffective, normal, and terminal kinetic populations of the erythron were studied in healthy girls aged 7-9 years and girls suffering from chronic pyelonephritis. The production of highly active macrocyte population, descending from terminal erythropoiesis, was increased during pyelonephritis remission, which determined reduction of serum iron concentration during the morning hours and leveling of its circadian rhythm because of high utilization of the trace element. Progressive reduction of erythrocyte count and hemoglobin content during the active phase of pyelonephritis correlated with the increase in the population of microcytes with low activity of glucose-6-phosphate dehydrogenase and short life span, paralleled by an appreciable increase in ferritin and MDA concentrations during the evening hours. Stimulation of alternative erythron kinetic types (terminal and ineffective) underlies these changes.
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PMID:Erythropoiesis and iron metabolism biorhythms in children with chronic pyelonephritis. 1924 Aug 44