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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A slide agglutination test to detect P-fimbriated Escherichia coli was developed by attaching glycosides containing the relevant receptor structure (alpha-D-Galp-(1-4)-beta-D-Galp) to particles. A suspension of these particles agglutinates within ten seconds when mixed with P-fimbriated bacteria. The test is named the P-specific particle agglutination test (PPA test). The PPA test is more sensitive than the haemagglutination assays previously used. The exclusive specificity of the PPA test also allows the detection of P-fimbriae on strains which additionally possess other fimbriae (e.g. X-fimbriae). Using this test, the frequency of P-fimbriated E. coli in children with acute non-obstructive pyelonephritis was shown to exceed 95%. In lower urinary tract infections the frequency of P-fimbriated E. coli was approximately 20%. Moreover, children with acute pyelonephritis were also found to be heavily colonized in both the periurethral area and the intestine with the identical P-fimbriated E. coli strain.
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PMID:P-fimbriae of pyelonephritogenic Escherichia coli: detection in clinical material by a rapid receptor-specific agglutination test. 613 84

We report 6 children who showed clinical symptoms and laboratory signs of acute pyelonephritis but in whom bacteriuria was insignificant, with Escherichia coli 10(4)/ml, or less. None of the children had symptoms of other disease. Three of the children who were at first treated inadequately or were not treated with antibiotics developed significant bacteriuria later on (10(5)/ml, or greater). Ultrasonic scanning to evaluate kidney involvement at the acute phase of disease showed transient changes in four of the 6 children--dilatation of one or both pelves or increased ecogenicity of the renal sinus, or both. The urinary E coli strains isolated from all 6 children were P-fimbriated, as determined by a P-fimbriae specific particle agglutination test (PPA test). P-fimbriate E coli are known to be strongly associated with acute non-obstructive pyelonephritis in children and we suggest that the finding of any number of P-fimbriated E coli in the urine of children with clinical evidence of acute pyelonephritis supports this clinical diagnosis.
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PMID:Low urinary counts of P-fimbriated Escherichia coli in presumed acute pyelonephritis. 614 97