Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0034186 (
pyelonephritis
)
6,144
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Clinical and fundamental studies were performed using Citrobacter freundii isolated from urine specimens of in- and out-patients between January 1980 and July 1981. The C. freundii (greater than 10(4)/ml) isolated from urine was closely related to chronic complicated urinary tract infection. MICs of pyridonecarbonic acids (ENX, OFLX and
NFLX
) and CMX against C. freundii were low. Pyridonecarbonic acids (ENX, OFLX and
NFLX
) and CMX showed good therapeutic effects against the experimental ascending
pyelonephritis
of mice according to their MICs. Against the experimental ascending
pyelonephritis
of cyclophosphamide-treated mice, pyridonecarbonic acids (ENX, OFLX and
NFLX
) showed good therapeutic effects. Experimental intraperitoneal infection of mice was made easily with a low inoculation dose by adding mucin. Pyridonecarbonic acids (ENX, OFLX and
NFLX
) and CMX showed good therapeutic effects against this experimental model. Experimental respiratory tract infection could not be made in the mice with the organism isolated from urine.
...
PMID:[Clinical and experimental studies on the pathogenicity of clinical isolated Citrobacter freundii]. 385 21
