Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Atypical organ and endometrial changes in 2 female patients under pe rmanent acyclic therapy with Lyndiol are reported. The 1st patient had undergone a bilateral nephrectomy for contracted kidneys due to pyelonephritis and died in uremic coma after extracorporal dialysis, bef ore the renal transplantation could be performed. She had been treated for profuse menorrhagia with 5 mg Lyndiol for 11 weeks. The so-called therapeutic pseudopregnancy found at the postmortem examination was attributed to the unintended accumulation of hormones due to the absence of the renal excretory organs as well as to liver damage from uremia and steroids. Besides the uremic damage, the administered steroids are obviously also responsible for the unusually extensive necroses found in the liver and the adrenal glands. In the 2nd case, permanent (15 months) therapy with Lyndiol was prescribed in order to eliminate meno-metrorhagias in chronic myelosis. Curettages were performed 2, 11, 14, and 21 months after treatment was begun. Besides the known contrary glandular and stroma reaction at the glandular epithelium as sign of its exhaustion, biopsy controls also revealed very extensive regressive chan ges similar to those seen in glandular hyperplasia, and also atypical regenerates. Characteristic features of differentiation from the choriogenic Arias-Stella phenomenon and from incipient carcinoma of the corpus uteri are pointed out.
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PMID:[Atypical organ-oriented effects of so-called ovulation inhibitors following bilateral nephrectomy, as well as unusual endometrial changes during long-term acyclic therapy for chronic myelosis]. 1215 26

Genetic mutations resulting in obesity and type 2 diabetes mellitus (T2D) are described for both inbred and outbred mice. However, no known mouse model completely recapitulates human T2D and its comorbidities. We identified a cohort of obese, male, outbred Swiss-Webster (SW) mice as polyuric, polydipsic, glucosuric, and hyperglycemic. Prevalence of glucosuria in the SW colony reached 60% (n=70) in males 8 weeks to 6 months of age. Despite severe obesity in some females, no females were diabetic. Pathologic findings in affected males included cachexia, dilated gastrointestinal tracts with poor muscular tone, pancreatic islet degeneration and atrophy with compensatory metaplasia and/or neogenesis, bacterial pyelonephritis, membranous glomerulopathy, and late-onset hepatic tumors with macrosteatosis, microsteatosis, and hydropic change in aged males. Serum insulin correlated with blood glucose in a nonlinear pattern, suggestive of islet exhaustion. Circulating leptin levels showed a weak inverse correlation with glucose. Diabetic males were bred with obese colony females to produce 20 male and 20 female offspring. Prevalence of diabetes in male offspring was 80% (16/20) with a median age of onset of 18 weeks. By contrast, no diabetic females were identified, despite being significantly more obese than males. Male predominance is likewise a feature of T2D in humans. To our knowledge, this is the first documentation of hepatocellular carcinoma and islet metaplasia and/or neogenesis in a spontaneous outbred mouse model of T2D. The SW availability and histopathologic features represent a promising new model for the study of T2D.
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PMID:Obesity and non-insulin-dependent diabetes mellitus in Swiss-Webster mice associated with late-onset hepatocellular carcinoma. 1866 86