Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 45-year-old woman, known to have a congenital exstrophy ofthe bladder, for which she underwent a ureterosigmoidostomy in her infancy, presented with fever. This was due to pyelonephritis, from which she recovered with antibiotic therapy. During colonoscopy a carcinoma of the sigmoid was found at the level of the anastomosis of the ureters. Patients with a ureterosigmoidostomy have a one hundred-fold increased risk of colon carcinoma compared to the general population. The development of malignant tumours as a long-term complication of this procedure is linked with the frequent contact between intestinal tissue and urine. Periodical colonoscopy of these patients is advised.
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PMID:[Sigmoid carcinoma as a long-term complication following ureterosigmoidostomy]. 1856 45

Ureterosigmoidostomy is a method for total diversion of the urinary stream away from the bladder and lower urinary tract into the sigmoid colon, the anus providing the continence mechanism for urine as well as for faeces. However, this type of urinary diversion has multiple serious mid- and long-term complications, including anastomotic colon cancer, ascendens urinary infection, hyperchloremic metabolic acidosis, electrolyte imbalance, incontinence and urinary stone. This case report describes the diagnostic and therapeutic approach to a case in which ureterosigmoidostomy had been carried out, with nephrectomy being performed 30 years following this intervention, after pyelonephritis developed by way of ascendens infection, and which was then operated on three years later, upon the appearance of sigmoid colon carcinoma.
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PMID:Complications associated with ureterosigmoidostomy--colon carcinoma and ascendens infection resulting in nephrectomy: a case report. 1980 73