Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The significance of Gardnerella vaginalis in urine was studied by comparing urine culture results, urinalysis data, and clinical findings. Over a two-year period, G vaginalis was reported in 2.3% of all urine cultures. Of 72 patients with pure cultures (greater than 10(4) cfu/mL), 43 patients (59.7%) were found to have G vaginalis urinary tract infections. Furthermore, four of the infected patients had pyelonephritis. Symptoms associated with G vaginalis urinary tract infections varied, and pyuria was detected in only 58% of the cases. Conditions associated with G vaginalis urinary tract infection included a history of recurrent urinary tract infections and/or instrumentation and upper urinary tract disease.
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PMID:Gardnerella vaginalis in the urinary tract: incidence and significance in a hospital population. 325 96

Bladder aspirate urine samples (N = 190) were cultured for the presence of fastidious microorganisms. These samples were obtained from patients with urinary tract disease in whom standard bacteriologic investigation had failed to indicate infection. Gardnerella vaginalis was recovered alone, or in association with Ureaplasma urealyticum from the bladder urine of 33% of patients with reflux scarring. G. vaginalis was localized to the upper urinary tract in 75% of these patients with bladder counts greater than 10(3) colony-forming units per milliliter. The results show that two fastidious microbial species, not conventionally associated with urinary tract infection, are recoverable from the upper urinary tracts of patients with so-called sterile pyelonephritis.
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PMID:Unconventional bacteria in urinary tract disease: Gardnerella vaginalis. 660 91

We aimed to analyze the strain-by-strain expression of a large panel of antimicrobial activities counteracting the virulence mechanisms of bacterial vaginosis-associated Prevotella bivia CI-1 and Gardnerella vaginalis 594, pyelonephritis-associated Escherichia coli CFT073, and recurrent cystitis- and preterm labor-associated IH11128 E. coli by Lactobacillus gasseri and Lactobacillus crispatus clinical strains, and L. gasseri ATCC 9857 and KS 120.1, and L. crispatus CTV-05 strains isolated from the cervicovaginal microbiota of healthy women. All L. gasseri and L. crispatus strains exerted antimicrobial activity by secreted lactic acid, which killed the microbial pathogens by direct contact. Potent bactericidal activity was exerted by a very limited number of resident L. gasseri and L. crispatus strains showing the specific ability to a strain to produce and release antibiotic-like compounds. These compounds eradicated the microbial pathogens pre-associated with the surface of cervix epithelial cells, providing efficient protection of the cells against the deleterious effects triggered by toxin-producing G. vaginalis and uropathogenic E. coli. Furthermore, these compounds crossed the cell membrane to kill the pre-internalized microbial pathogens. In addition, all L. gasseri and L. crispatus cells exhibited another non-strain specific activity which inhibited the association of microbial pathogens with cervix epithelial cells with varying efficiency, partially protecting the cells against lysis and detachment triggered by toxin-producing G. vaginalis and uropathogenic E. coli. Our results provide evidence of strain-level specificity for certain antimicrobial properties among cervicovaginal L. gasseri and L. crispatus strains, indicating that the presence of a particular species in the vaginal microbiota is not sufficient to determine its benefit to the host. A full repertory of antimicrobial properties should be evaluated in choosing vaginal microbiota-associated Lactobacillus isolates for the development of live biotherapeutic strategies.
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PMID:Diverse Expression of Antimicrobial Activities Against Bacterial Vaginosis and Urinary Tract Infection Pathogens by Cervicovaginal Microbiota Strains of Lactobacillus gasseri and Lactobacillus crispatus. 3192 Oct 75