Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Severe renin-mediated hypertension was noted in 2 children as a result of selective renal damage from vesicoureteral reflux during the early years of life. In each case the reflux had been corrected successfully long before hypertension developed. In 1 case the late damage involved only 1 kidney and nephrectomy resulted in immediate relief of the hypertension. In the second case, even though both kidneys showed segmental scarring from calicectasis and chronic pyelonephritis, removal of the atrophied lower pole of 1 kidney made hypertension amenable to medical treatment and reduced excessive renin output to a fraction of the original high levels. The mechanism of renin-mediated hypertension in kidneys with segmental scars of chronic pyelonephritis is believed to be ischemia of the relatively normal renal cortex in proximity to areas of interstitial fibrosis, within which are tortuous interlobular and smaller arterioles with severe intimal thickening. Hypertrophy of normal renal segment occurs in young patients with segmental chronic pyelonephritis. To accommodate this enlargement the original calix develops an extension or elongation readily distinguishable from other dilated calices.
 ...
PMID:Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. 61 6

The occurrence of ureteral fistulas as a complication of obstetrics is very rare, mostly occurring in developing countries. Only 2 cases of ureterouterine fistulas following dilation and curettage (D & C) have been reported. A 3rd case is reported in this paper. Diagnosis was made by an excretory urogram (IVP). After D & C the patient had hemorrhaged profusely and the IVP showed prominent calicectasis with hydronephrosis in the right kidney. After clinical stabilization, treatment of the pyelonephritis and evaluation of the bleeding disorder, a right percutaneous nephrostomy tube was inserted and vaginal drainage of urine ceased. Later the patient was hospitalized for an elective repair of the ureterouterine fistula. Right ureteroneocystosomy with a psoas hitch was performed to bridge th gap of the ureter to the bladder.
 ...
PMID:A case report: ureterouterine fistula as a complication of elective abortion. 710 49

Ninety-eight children have been treated with clean intermittent catheterization (CIC) over a five-year period. Follow-up in 73 of these is presented herin. The complication rate encountered with the technique is low (7 per cent major complications). Only 21 per cent of the patients were able to maintain persistently sterile urine, although no new bouts of pyelonephritis were encountered in the group since our report of three years ago. Six of 44 (14 per cent) refluxing renal units stopped refluxing on CIC, but in two units reflux de novo developed while on treatment. Most patients (79 per cent) demonstrated stable upper tracts on CIC, while 14 per cent showed increased calicectasis with 7 per cent showing improvement. Thirty-one of the patients were less than three years of age when begun on clean intermittent catheterization. We recommend CIC as the treatment of choice in neurogenic vesical dysfunction where total bladder emptying is a problem and advise that it be started as early as possible.
 ...
PMID:Five-year experience with clean intermittent catheterization in children. 711 14

Basing on the data obtained on percutaneous removal of stag-horn nephroliths in 81 patients (44 females and 37 males aged 10-65), the authors discuss the operative technique and surgical results. The patients were divided into 4 groups depending on the stone size, its position in the pelvicaliceal system, the presence and severity of calicectasis. Nephroliths sizes ranged from 3.5 to 10 cm. Better treatment results were obtained in those patients who had the main mass of the stone in renal pelvis and in those with pyelocalicectasis. After the treatment 72 patients (88.8%) were free of the stones. Common among complications were episodes of pyelonephritis after the intervention and displacement of the nephrostomy drainage. The authors gained primary experience which supports benefit of percutaneous surgery of stag-horn nephroliths.
 ...
PMID:[The percutaneous endoscopic treatment of staghorn nephrolithiasis]. 794 Nov 53