Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Different electrophoretic mobility of urine lysozyme was established in patients with chronic glomerulonephritis and chronic pyelonephritis during electrophoresis in 12% polyacrylamide gel (gel pH 4.3, electrode buffer pH 4.0). The examination of 128 patients has shown that anode position of lysozyme in electrophoretic tubes is observed in 95% of patients with chronic pyelonephritis, and its anode position in 92% of patients with chronic glomerulonephritis. A method of urine lysozyme electrophoresis under the above conditions was proposed as a noninvasive method of differential diagnosis of chronic glomerulonephritides and chronic pyelonephritides.
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PMID:[Study of electrophoretic mobility of urinary lysozyme in the differential diagnosis of chronic glomerulonephritis and chronic pyelonephritis]. 320 66

Of 168 urine sediments, which were obtained from 55 patients with chronic pyelonephritis in the course of 3 years when a significant bacteriuria with E. coli was present, we demonstrated antibody-loaded bacteria in 81 cases (48.21%). In the active stage of the disease with 54.10% were found significantly more than in the inactive with 32.61%. In obstructive chronic pyelonephritis the positive rate was 54.79% in contrast to 43.16% in non-obstructive chronic pyelonephritis. While in the active stage of the obstructive chronic pyelonephritis with 57.41% more antibody-containing bacteria were excreted than with 47.31% in the inactive stage, the positive rate in the active stage of the non-obstructive chronic pyelonephritis was with 54.47% significantly increased in contrast to 22.22% in the inactive stage. 25.71% of the patients excreted only ACB+-, 34.29% only ACB(-)- and 40% ACB+- and ACB(-)-germs in the course of the disease. The ACB-positive quote was in rough forms with 62.50% statistically significantly increased in contrast to 45.54% in O-typable and 42.86% in non-O-typable strains. In the ACB+- group the immunofluorescence titres to the homologous strain and the C3-activator in the serum as well as the urine lysozyme were significantly higher than in the ACB(-)-group.
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PMID:[Incidence of antibody-coated bacteria in patients with chronic pyelonephritis]. 355 85

In the course of 4 years we isolated 193 E. coli strains of 55 patients with chronic pyelonephritis. In patients with obstructive chronic pyelonephritis the mean value of the immunofluorescence titre (in the serum) to the E. coli strain excreted in the urine as well as the total complement were significantly increased, the serum lysozyme was significantly lower than in patients with non-obstructive chronic pyelonephritis. A relation to the activity of the disease was existing only in the non-obstructive chronic pyelonephritis, where in the active stage the total complement was significantly decreased, the complement factors C3 and C4 as well as the urine lysozyme were significantly increased in comparison to the inactive stage. 94.64% of all immunofluorescence titres obtained to the homologous strain in the patients' serum were above the border of the normal area of 1:40. A relation between level of the titre and activity of the disease could not be established. No significant differences could be proved between the titres taken to serum-sensitive and serum-resistant strains. In 32.73% of the patients we observed disturbances of the serum bactericidia against the homologous serum-sensitive E. coli urine strain at one or several points. They fall to equal shares to patients with obstructive and non-obstructive chronic pyelonephritis and were found at 66.67% in the active stage of the two forms of the disease. In patients with and without disturbances of bactericidia no significant differences in the total complement, in the complement factors C3 and C4, the C3-activator, the serum lysozyme and the immunofluorescence titres could be proved.
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PMID:[Defense mechanisms of the macro-organism in bacteriuria in chronic pyelonephritis]. 355 86

Antimicrobial effect of lysozyme in combination with a wide set of antimicrobial drugs (38) was studied with respect to 74 bacterial cultures. It was shown that synergism of the antimicrobial effect in the presence of lysozyme was variable for drugs differing in the mechanism of their action and depended on the pathogen species. The most pronounced synergistic effect was observed with respect to grampositive bacteria with the use of many drugs such as benzylpenicillin, ampiox, morphocycline, erythromycin and others. The potentiation effect of lysozyme was less pronounced with respect to Coli bacteria and Pseudomonas. Combination of lysozyme with aminoglycosides such as gentamicin, tobramycin, sisomicin and amikacin resulted in increasing antimicrobial effect with respect to practically all the microbial cultures tested. The clinical trials of the efficient combinations of the antibiotics and lysozyme studied experimentally proved their high efficacy in combined therapy of patients with pneumonia and pyelonephritis of bacterial genesis. Thus, in children with acute pneumonia (92 observations) it resulted in more rapid elimination of the temperature reaction, toxic and cardiorespiratiry syndromes, cough and physical signs of the disease. In treatment of 83 children with pyelonephritis complete clinico-laboratory remission was observed in 81 per cent of the cases against 56.4 per cent in the patients treated with the antibiotics without lysozyme.
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PMID:[Experimental and clinical study of the use of lysozyme in combination with chemotherapeutic agents]. 356 22

The effect of subinhibitory doses of 25 antibiotics on the antilysozyme property of enterobacteria considered as a marker of their persistence was studied. This provided dividing the antibiotics into 3 groups: antibiotics increasing the bacterial capacity for lysozyme degradation, antibiotics indifferent with respect to this property and antibiotics decreasing it. Decreasing of the Salmonella antilysozyme activity by gentamicin under experimental conditions promoted suppression of the bacteria parasitism in Hep-2 cells. Clinical and laboratory studies on the effect of antibiotic therapy under the control of the time course of the antilysozyme property of the pathogen in patients with acute dysentery, pyelonephritis and inflammatory processes in the female genitalia showed that the use of the antibiotics increasing this property in the pathogen was not advisable which was confirmed by the absence of significant clinical improvement in the patients and necessity of prolonging the sanative period.
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PMID:[Bacterial antilysozyme activity and its regulation by antibiotics]. 367 41

In animals developing unilateral Proteus mirabilis-induced pyelonephritis, the total soluble renal lysozyme (SRL) of both kidneys undergoes a biphasic elevation. The second phase of elevated SRL is associated with the onset of chronicity in the infected kidney. To discover whether effective antibacterial therapy altered the second elevation of SRL, levels of SRL were determined in rats developing unilateral chronic pyelonephritis with and without effective regimens of antibacterial agents. Therapeutic doses of ampicillin and nitrofurantoin caused elevations of SRL in both kidneys of infected animals, but these differences were not statistically significant (P > 0.05). Both agents produce elevations of SRL in uninfected animals which were significant (P < 0.05) when compared with normal animals. Kanamycin sulfate at a therapeutic dose induced great elevations of SRL in kidneys of both infected and uninfected animals. It is concluded that infection per se is not the cause of the elevated SRL.
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PMID:Effect of antibacterial therapy on renal lysozyme levels in rats developing bacterial pyelonephritis. 461 54

On the assumption that increased urinary lysozyme concentration (;lysozymuria') indicates tubular proteinuria and therefore impaired tubular function, urinary lysozyme has been estimated in acute disorders where transient disturbances of renal function might be expected, in cases diagnosed clinically as extrarenal uraemia, and in a few examples of acute renal disease. Reversible lysozymuria occurred with hypokalaemia, postoperative ;collapse', electrolyte depletion, severe extrarenal infection, acute pyelonephritis, the nephrotic syndrome, after a few apparently uncomplicated surgical operations, and very transiently after ventricular fibrillation abolished by DC shock. There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis. Although lysozymuria may occasionally be useful in the clinical diagnosis of acutely disordered renal function, the results suggest that its value is limited; on the other hand, they have provided information on renal pathophysiology in acute disease.
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PMID:Lysozymuria and acute disorders of renal function. 470 97

In animals developing experimentally induced unilateral pyelonephritis, both the infected kidney (IK) and the contralateral noninfected kidney (NIK) showed an immediate increase in renal lysozyme activity of about 5 days' duration after the unilateral injection of viable Proteus mirabilis into the renal cortex. Lysozyme activities of the NIK were consistently higher than those of the IK. This initial increase was followed by a second increase which lasted throughout the period of observation (17 days), and enzyme activities of the NIK were consistently higher than those of the IK. In saline punctured kidneys of control animals, both the saline punctured kidney (SP) and the non-saline punctured kidney (NSP) showed only the immediate increase in renal lysozyme activity, which persisted until the SP was completely healed. These enzyme activities were less than those observed in the infected animals, but the response of the NSP was greater than that of the SP. Trauma not directed to the kidney does not produce a similar response of renal lysozyme. The elevated renal lysozyme of the NIK could not be shown to protect it from bacterial infection.
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PMID:Renal lysozyme levels in animals developing Proteus mirabilis-induced pyelonephritis. 554 3

In a survey the present possibilities are outlined to get knowledge about diseases of inner organs with the help of enzyme determinations in the urine. Here it is remarkable that changes of the enzyme excretion appear not only in renal disease with acute renal failure, pyelonephritis, glomerulonephritis, renal infarction and nephroptosis but are also to be observed in primarily extrarenal diseases such as diabetes mellitus, hyperthyroidism, thesaurismoses, myocardial infarction, hypertension, acute pancreatitis, epidemic hepatitis, liver cirrhosis, obstructive jaundice and rheumatoid arthritis. The causes of the changes of enzyme excretions are various. Since enzymes of different origin and localisation behave themselves variably, the simultaneous determination of a brush border marker (e.g. alanine aminopeptidase), a lysosomal enzyme (e.g. beta-glucuronidase or N-acetyl glucosaminidase) and a low molecular enzyme (e.g. lysozyme) is of use for the recognition of renal alterations. By the control of activities of urinary enzymes it is possible to get without risk informations about pathobiochemical processes in the kidney which are not to be gained by means of other methods.
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PMID:[Urinary enzyme excretion in diseases of the internal organs]. 636 87

The presence of tubular involvement, as a marker for the detection of urinary tract infection (UTI) site, was examined in 19 patients with pyelonephritis and in 15 patients with cystitis or asymptomatic bacteriuria. The urinary excretion of four markers of tubular proteinuria, beta 2-microglobulin (beta 2M), lysozyme (LZ), lactic dehydrogenase isoenzyme V (LAD-5) and N-acetyl-beta D-glucosaminidase (NAG), was investigated. LAD-5 appeared particularly valuable for the early detection of upper UTI. However, the overall diagnostic accuracy appeared to be further strengthened using, besides LAD-5, one additional variable. A set of simple and noninvasive biochemical tests on urine samples can reliably help to identify the site of UTI.
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PMID:Contribution of four markers of tubular proteinuria in detecting upper urinary tract infections. A multivariate analysis. 675 51


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