Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

8 patients with chronic pyelonephritis were given gentamycin intramuscularly injected in individual dosage during 8-10 days. Here the behaviour of the excretion of protein, alanine aminopeptidase alkaline phosphatase, alpha-glucosidase, gamma-glutamyl transpeptidase and lysozyme with the urine was tested. With the exception of the lysozymuria, which increased only in patients with chronic renal insufficiency, regularly a hyperenzymuria developed. Most distinctly the excretion of the alanine aminopeptidase increased. After initial decrease the excretion of total protein transiently increased after completion of the gentamycin therapy. All the deviations were reversible. From the increased excretion of enzymes may not be concluded to a nephrotoxicity of gentamycin.
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PMID:[The effect of therapeutic gentamycin doses on the enzyme secretion in urine]. 0 Aug 56

The behaviour of serum and urinary lysozyme was investigated before and after renal transplantation in 20 patients. The mean postoperative observation time was 67.8 (10 to 212) days. In 11 patients with reversible olig-anuria due to prolonged preoperative ischaemia, lysozymuria lasted for a period of 17 days after surgery, whereas in 8 patients with immediate transplant function lysozymuria disappeared 7 days after transplantation. Serum lysozyme concentrations were markedly elevated before transplantation in all patients. In patients with transplant failure due to ischaemia, normalization of serum lysozyme levels was achieved 28 days after surgery; patients with immediate function showed normal serum lysozyme levels already 7 days after transplantation. Prolonged lysozymuria was also noticed in 2 cases with irreversible ischaemic transplant failure, in 1 case with recurrence of glomerulonephritis and in 1 further case with acute pyelonephritis in the transplant. In 7 cases with an acute renal rejection crisis, lysozymuria was evident 0.7 days before clinical diagnosis of rejection. Serum lysozyme levels showed a strong correlation with serum correlation with serum creatinine concentrations. Therefore, lysozymuria in renal transplant patients indicates tubular transplant damage of varied aetiology. Elevated serum lysozyme levels, on the other hand, seem to reflect a reduced glomerular filtration rate.
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PMID:[Behaviour of serum and urinary lysozyme after renal transplantation (author's transl)]. 32 38

In 183 patients with chronic pyelonephritis as unspecific humoral immune parameters CH50E, CB50E, C3, C4 and lysozyme as well as the indirect phagocytosis against Staphylococcus aureus SG 511 and E. coli were tested. Clinically a differentiation according to 3 degrees of the renal function and 3 degrees of the activity of the disease was performed. The statistical analysis took into consideration mean and limit values. With the help of contingency tables tendency pictures were developed. C3, C4 and lysozyme proved as suitable for a humoral immunogramme in chronic pyelonephritis. C3 was increased in clear activity, C4 and lysozyme in restricted renal function and expressed activity. In view of the high biologic variation of humoral test parameters advantages and disadvantages of an immunogramme are discussed. But for patients with chronic pyelonephritis finally the estimations of IgM, IgG, IgD, C3, C4 and lysozyme are regarded as clinically useful. A feasable immunologic test set should be controlled, precised and completed.
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PMID:[The clinical value of unspecific humoral immune parameters. Attempt at an immunogram. II. Quantitative determination of CH50E, CB50E, C3, C4 and lysozyme and measurement of indirect phagocytosis rate in the serum of patients with chronic pyelonephritis]. 38 56

In order to assess to what extent glomerular or tubular function is involved in the renal handling of amylase and the lysozyme to creatine clearance ratios (CAm/CCr and CLys/CCr) were evaluated in 22 healthy volunteers and in 71 patients with different renal diseases. In normal controls, the mean CAm/CCr was 2.55 +/-1.54 SD, with an upper normal limit of 5.56. A normal ratio was found in patients with glomerulonephritis, with or without a nephrotic syndrome, and in patients with pyelonephritis. A significantly elevated ratio (P less than 0.001) was instead found in patients with uremia and in patients with uremia and in patients with either chronic or acute tubular damage. The CLus/CCr ratio was elevated in all the groups, except in patients with glomerulonephritis and minimal proteinuria. These results show that in humans, as in animals, the amylase filtered load undergoes partial tubular reabsorption. In renal diseases, an increase of the CAm/CCr is caused by either a marked reduction of functioning nephrons or a severe tubular damage, while the glomerular permeability does not seem to be involved. Some other mechanism is probably involved in the elevation of the CAm/CCr during acute pancreatitis.
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PMID:Amylase to creatine clearance ratio in renal diseases. 44 31

Urinary excretion of lysozyme was investigated in a group of 66 patients with various renal diseases, nephrolitiasis and urinary tract infections. The results obtained demonstrate that the amount of the enzyme excreted is related to the entity of tubular damage whereas is not with glomerular damage. No correlation was found between lysozyme excretion neither to the degree of proteinuria neither to the amount of leukocytes and bacteria in the urine. In patients with urinary infections urinary lysozyme increases only when there is a tubular injury of some entity. In 90 pediatric patients with urinary infection and pyelonephritis lysozyme in the urine was found only in two cases. Therefore urinary lysozyme determination cannot be considered for the detection of early tubular injury and is not a helpful diagnostic tool in urinary tract infections.
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PMID:[Behaviour of urinary excretion of lysozyme in renal diseases and in urinary tract infections (author's transl)]. 102 90

One hundred and twenty patients (64 men and 56 women, aged 19 to 63) with chronic pyelonephritis were subdivided into two groups: a control group of 30 subjects and an experimental one of 90 subjects. Experimental subjects underwent short wave therapy (460 MHz, 50-60 W, for 8-20 minutes) in the lumbar area. Lumbosacral pain disappeared in 87 out of 90, subjects, intercostal pain in 20 out of 28, headache mitigated in 40 out of 53, asthenia was markedly reduced in 49 out of 50. Systolic and diastolic hypertension was reduced, as well as the Kakorski-Addis count in urine. Diurnal diuresis and lysozyme increased, while IgG, IgA and IgM were reduced.
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PMID:[Effects of short-wave therapy in patients with chronic pyelonephritis]. 183 63

Experimental materials on choosing antibiotics for etiotropic therapy of opportunistic infections with an account of the regulating effect of the drugs on the ++anti-lysozyme activity of pathogens (the factor of intracellular parasitism) are presented. The in vitro data were applied to the clinical trials in 30 patients with chronic and acute pyelonephritis of the Proteus etiology and to 25 patients with chronic inflammatory diseases of Staphylococcus etiology. It was shown that the use of the antibiotics which lowered the ++anti-lysozyme activity of microorganisms promoted a more rapid disappearance of the disease clinical signs, increased 2- to 3-fold the terms of the remission and resulted in an increase in the number of the persons with complete remission (54.5 to 63.6 per cent) as compared to the use of the drugs which stimulated the pathogen property or were indifferent to it.
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PMID:[Experimental and clinical studies of drug regulation of the anti-lysozyme activity of microorganisms causing opportunistic infections]. 202 9

The results of the treatment of 47 babies treated with the immunocorrecting drugs (t-activin, levamisole, sodium nucleinate, prodigiozan, lysozyme) together with antimicrobial remedies are described. The babies were selected from 120 patients suffering from pyelonephritis. Indications for use of the immunomodulators included the deficiency of the T component of immunity, of phagocytosis and, more rarely, of B lymphocytes, an unfavourable premorbed condition, severe lingering disease course as well as low efficacy of antibacterial therapy. Two control groups consisted of 120 patients who were not given the immunocorrecting remedies and 30 normal children of the first year of life. The immunostimulation therapy minimized the duration of the active phase of pyelonephritis, decreasing the rate of relapses and the probability that the disease may progress to a chronic course. The positive influence of the above drugs on the clinical picture of pyelonephritis enabled the duration of antibacterial therapy, the dosage and the frequency of antibiotic use to be reduced. The favourable outcome of pyelonephritis was followed by gradual normalization of the immunological parameters.
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PMID:[Clinico-pathogenetic substantiation of the immunocorrective treatment of pyelonephritis in infants]. 234 36

Of 168 urine sediments, which were obtained from 55 patients with chronic pyelonephritis in the course of 3 years when a significant bacteriuria with E. coli was present, we demonstrated antibody-coated bacteria in 81 cases (48.21%). In the active stage of the disease with 54.10% were found significantly more than in the inactive with 32.61%. In obstructive chronic pyelonephritis the positive rate was 54.79% in contrast to 43.16% in non-obstructive chronic pyelonephritis. While in the active stage of the obstructive chronic pyelonephritis with 57.41% more antibody-coated bacteria were excreted only ACB+-, 34.29% only ACB-- and 40% ACB+- and ACB--germs in the course of the disease. The ACB-positive quote was in rough forms with 62.50% statistically significantly increased in contrast to 45.54% in O-typable and 42.86% in non-O-typable strains. In the ACB+-group the immunofluorescence titres to the homologous strain and the C3-activator in the serum as well as the urine lysozyme were significantly higher than in the ACB--group.
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PMID:[Excretion of antibody-coated bacteria in chronic pyelonephritis]. 269 41

Two new laboratory diagnostic tests for chronic glomerulonephritis and pyelonephritis have been developed. The first one is based on electrophoretic mobility of urinary lysozyme under certain conditions, such as the use of 12% polyacrylamide gel with pH of 4.3 and acid electrode buffer with pH of 4.0. After electrophoresis was discontinued, lysozyme position was determined by lysis of Micrococcus lysodeikticus, used as test agents and added to the gel as a suspension prior to polymerization. Urinary lysozyme was found to be in the anode area of the gel in 95% of patients with chronic pyelonephritis, and in its cathode area in 92% of patients with chronic glomerulonephritis. There was no lysozyme in the urine of normal subjects. The other laboratory technique, the ethanol test, is based on comparative assessment of the degree of urinary opacification after ethanol is added in conditions of neutral reaction (following the addition of physiologic saline) and marked alkaline reaction (following the addition of sodium hydroxide solution). The ratio of optic density of the alkaline specimen to that of the neutral specimen was above 1 in patients with chronic glomerulonephritis, and below 1 in patients with chronic pyelonephritis and normal subjects. Examination of biochemical mechanisms of the proposed tests has demonstrated that the pattern of proteinuria is the most important factor affecting the results.
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PMID:[New methods in the laboratory diagnosis of chronic glomerulonephritis and chronic pyelonephritis]. 271 91


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