Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As many as 142 patients with calculous pyelonephritis were examined for the system of hemostasis. It is shown that pyelonephritis is characterized by hypercoagulation shifts according to the echitox test, by the high content of fibrinogen and its degradation products, thrombinemia, a decrease of the antithrombin III level, and by high heparin resistance of plasma. At the same time there was a reduction of fibrinolysis. Thirty-six patients with the most pronounced disorders of hemostasis underwent multimodality treatment including plasmapheresis which favoured an improvement of the patients' status. The body temperature declined, the signs of intoxication disappeared, and the well-being improved. Hypercoagulation tended to disappearance, whereas the content of fibrinogen and its degradation products decreased. The level of antithrombin III rose and plasma resistance to heparin disappeared. At the same time the characteristics of the paracoagulation tests identifying thrombinemia remained unchanged. No noticeable changes in fibrinolysis were recorded. It is suggested that plasmapheresis should be widely used in multimodality treatment of pyelonephritis.
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PMID:[Use of plasmapheresis in multimodality correction of hemostasis disorders in patients with calculous pyelonephritis]. 279 24

Plasma antithrombin III (AT III) activity was examined retrospectively in patients with preeclampsia-eclampsia, chronic hypertension, and chronic hypertension with superimposed preeclampsia-eclampsia. Levels of AT III were greater than 1 SD below normal pregnant control in each case of preeclampsia-eclampsia syndrome. The degree of reduction in plasma AT III activity was correlated with the severity of disease. AT III activity was within normal limits in patients with chronic hypertension. AT III activity dropped prior to the appearance of clinically evident disease in three patients who were followed from an early gestational age. In no instance was low plasma AT III activity associated with normal pregnancy. Coincidental disease, including pyelonephritis and a viral syndrome, were associated with markedly decreased levels of plasma AT III activity in otherwise normal pregnancies. Plasma AT III activity may be valuable as a tool in diagnosing preeclampsia-eclampsia, as a screening test for preclinical preeclampsia-eclampsia, and as an indicator of severity of disease.
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PMID:Plasma antithrombin III activity: an aid in the diagnosis of preeclampsia-eclampsia. 706 16