Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The 10-year experience of the urological clinic of M.F. Vladimirsky Research Clinical Institute included treatment of 219 patients (age 21-68 years, mean age 52.3 +/- 12.4; 59.2% females, 40.8% males) with urolithiasis which developed in the presence of anomalies of the kidneys and upper urinary tract. Uroliths were detected in the kidneys with homolateral (n = 51, 23.7%), lumbar (n = 49), iliac (n = 1), pelvic (n = 2) dystopia. Chest and heterolateral dystopia of the kidneys were not detected. Extracorporeal shock-wave lithotripsy (ESWL) was used in 38 (77.6%) patients, 11 (22.4%) patients were treated by other methods. A short-term effect of ESWL consisted in elimination of most of the concrement fragments while the residual fragments had no clinical symptoms being maximally 4-5 mm in size. It was noted in 23 of 38 (60.5%) patients. Six months after ESWL elimination of the concrement from lumbar-dystopic kidney occurred in 27 (71.05%) of 38 patients. Residual fragments 6-10 mm in size were registered in 26.35% patients, more than 10 mm--in 1 (2.6%). Complications after ESWL monotherapy of the concrements of the lumbar-dystopic kidney were seen in 26.3% (acute pyelonephritis 10.6%, stone track--7.9%, total hematuria--2.6%, acute prostatitis--2.6%, renal colic--2.6%). Mean treatment duration was 15.4 +/- 3.3 days. Thus, most effective therapy ofdystopic kidneys urolithiasis is ESWL the total efficacy of which reached 71.05%.
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PMID:[Extracorporeal shock-wave lithotripsy in the treatment of urolithiasis of dystopic kidneys]. 1670 81

Efficacy of polyoxidonium was studied in combined therapy of urolithiasis complicated with secondary pyelonephritis. Of 60 patients with secondary pyelonephritis in urolithiasis, 30 received adjuvant polyoxidonium. Phospholipids and cholesterol in cytomembranes were defined with thin-layer chromatography. Humoral immunity was evaluated by the levels of IgA, IgM, IgG, hemolytic activity of the compliment system, the level of circulating immune complexes, activity of lysozyme. Concentrations of IL-1beta, TNF, IL-4, IL-6 were also estimated. Subpopulations of immunocompetent cells were tested on flow cytofluorimeter by immunofluorescence with monoclonal antibodies. Phagocytic component of the immune system was assessed by phagocytic activity of neutrophils, phagocytic count, NBT test. The trial demonstrates that polyoxidonium has a positive action on the disease course, an antiinflammatory, immunomodulating properties, suppresses peroxidation, promotes recovery of structural-functional characteristics of cellular membranes in patients with urolithiasis and secondary pyelonephritis. Polyoxidonium is recommended in secondary pyelonephritis and urolithiasis as adjuvant to basic therapy for anti-inflammatory, detoxication and immunomodulating effect.
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PMID:[Polyoxidonium in the treatment of calculous pyelonephritis]. 1670 92

Megacalycosis is an uncommon, congenital renal abnormality, characterized by nonobstructive dilatation of the renal calyces with normal renal pelvis, ureter and bladder. This condition is due to underdevelopement or hypoplasia of Malpighie's pyramids. It usually occurs unilateraly as the isolated anomaly with strong male predominance. Megacalycosis itself does not impair the renal function but it can be the cause of urinary tract infections and calculus formation. This congenital defect is incidentally found by urography during the examination for urolithiasis or urinary tract infections or calculus formation. The images on radograms can be confused with obstructive or refluxing hydronephrosis or postinflamtory changes typical for pyelonephritis chronica. In case of megacalycosis surgical treatment is unnecessary. Patients with this condition should be followed-up with ultrasound and prevention of urinary tract infections or urolithiasis. Here we would like to report on the case of megacalycosis in a ten-year-old girl reffered to our deprtament due to UTI. Diagnosis of megacalycosis was established by typical urography findings: dilatation of renal calyces, no distention or obstruction of renal pelvic and ureter. The renal function was normal. No evidence of abnormality in cystoureterogram and uroflowmetry test was detected.
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PMID:[Megacalycosis as a diagnostic problem in children]. 1689 12

Urinary tract calculi have been reported to account for between 1 in 1,000 and 1 in 7,600 hospital admissions in children in the USA. The annual incidence of urolithiasis in patients older than 10 years is 109 per 100,000 of the population in men and 36 per 100,000 of the population in women in Minnesota. The use of various medications is considered to be one of the etiologic factors of nephrolithiasis. Ceftriaxone is a widely used third-generation cephalosporin that is generally considered very safe, but complications such as biliary pseudolithiasis, and rarely, nephrolithiasis have been reported in children. There is limited information about urolithiasis as a side effect of ceftriaxone. The aim of this study was evaluation of the incidence of nephrolithiasis following ceftriaxone therapy in children. This quasi-experimental before and after study was conducted in Mofid Children's Hospital between 2003 and 2005. All patients were treated with 75 mg/kg intravenous ceftriaxone. Diagnosis of pyelonephritis was based on standard criteria. The first renal ultrasonography was performed on the first or second day of admission and was repeated on the last day of treatment. We also evaluated complicated patients for the third time with renal ultrasonography 3 months after treatment. Stone-forming patients underwent metabolic kidney stone risk factor evaluation. We evaluated 284 patients with pyelonephritis, 185 girls and 99 boys. The first ultrasonography was normal in all of our patients. On the second ultrasonography renal stones were reported in 4 out of 284 cases (1.4% and CI=0.96-1.83%). Underlying metabolic risk factors could not be identified in stone-forming patients. Follow-up ultrasonography 3 months later was normal. The results of our study suggest that ceftriaxone-treated patients may be at an increased risk of kidney stone formation. Stones passed spontaneously in all affected patients so the use of this effective drug can be safely continued. Close monitoring of ceftriaxone-treated patients with regard to kidney stone formation is recommended.
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PMID:Ceftriaxone associated nephrolithiasis: a prospective study in 284 children. 1722 43

The study of dietary supplement (biologically active additive) Prolit in 20 patients and 20 controls (mean age 44.0 +/- 13.8 years) hospitalized for urolithiasis, uncomplicated renal colic proved that Prolit use in combined therapy of urolithiasis effectively relieves pain syndrome (renal colic) and prevents its recurrence. Prolit has a pronounced anti-inflammatory and spasmolytic effects which prevent attacks of acute (chronic) pyelonephritis. Combined treatment of urolithiasis with Prolit addition has one more advantage over conventional therapy in evacuation of the concrements and elimination of urostasis, especially in small concrements (up to 1 cm) in the ureter.
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PMID:[Prolit in combined treatment of urolithiasis]. 1747 98

Chronic renal failure (CRF) remains a significant cause of mortality in Yemen. There are about 568 patients with end-stage renal failure (ESRD) who receive chronic hemodialysis in seven centers in Yemen. We studied 372 CRF patients admitted for evaluation at our center from June 1997 to December 2000 in order to determine the pattern of etiology of their renal disease. Of the study patients, 253 (68%) were males and the age ranged from 4 to 80 years with a mean of 42.7 +/- 38 years. There were 215 (57.8%) patients who had unknown causes of CRF, followed by post-renal causes such as urolithiasis and pyelonephritis. Hyper-tension and diabetes mellitus were the least encountered etiologies in our study patients. There were 243 (66.3%) patients who required dialysis because of symptoms and signs of advanced renal failure; 60.2% of them were hypertensive, 80.3% were anemic with a mean hemo-globin of 79.6 gm/l, 26.9% were hyperkalemic, 52.6% were hypocalcemic and 61.0% had hyper-phosphatemia. We conclude that there are serious diagnostic and therapeutic problems in our health-care system that need addressing in order to improve health care.
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PMID:Causes of Chronic Renal Failure at one Center in Yemen. 1765 96

High efficacy of endoscopic treatment of urolithiasis in adults stimulated its introduction in the strategy of urolithiasis management in children. 133 ureteropyeloscopies with ureterolithotripsy and ureterolithoextraction was performed in 121 children (boys and girls, age 11 months to 16 years). Concrements (0.5-2.0 cm and larger) located in the caliceal-pelvic segment, ureter, 12 patients had bilateral urolithiasis. Ineffective extracorporeal lithotripsy (ELT) was followed by ureteropyeloscopy in 86 (71%) cases. Rigid and fibroureteropyeloscopes were used. Due to ureterolithotripsy and lithoextraction, concrements were removed completely in 98 (80.9%) patients including 5 children with ligature concrements and 11 children with ureteral strictures which required additional endoureterotomy and removal of ligature. In 23 (18%) cases when migration of concrements and their fragments did not allow complete elimination of the concrements, the kidney in ureteropyeloscopy was drained by catheters or stents with further ELT. Postoperative exacerbation of pyelonephritis treated conservatively was registered in 20 (16.5%) children. Long-term complications were not seen. Thus, transurethral uretheropyeloscopy with lithotripsy and lithoextraction is highly effective, low invasive, safe treatment of urolithiasis in children in failure of ELT.
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PMID:[Transurethral ureteropyeloscopy with lithotripsy and lithoextraction in children]. 1772 31

The aim of the study was elucidation of levofloxacin (tavanik) efficacy in transcutaneous nephrolithotripsy (TNLT) made to prevent or treat infectious-inflammatory complications. We performed 211 transcutaneous endoscopic operations on the kidneys for urolithiasis (71 males and 117 females). Of them, 47 (25%) patients received tavanik. The concrement was located in the pelvis (n=9), calyx (n=9), pelvoureteral segment (n=5). Coral concrements were found in 24 cases (K1--in 12, K2--in 6, K3--in 3, K4--in 3 patients). Nephrolitholapaxy was performed in 39 patients, nephrolithoextraction--in 8 patients. Duplex ultrasound dopplerography conducted in all the examinees before surgery and on day 5-6 after it gave information about renal blood flow. Duration of the operation varied from 20 minutes in nephrolithoextraction to 136 minutes in nephrolitholapaxy of the coral concrements (mean time 40 +/- 6 min). Tavanik' was given according to the following scheme: 24 hours before the operation 500 mg tavanik was given orally, on the day of surgery and 3 consequent days 500 mg intravenously dropwise, the next 4 days 500 mg orally. Thus, a course of tavanik lasted 8 days. Nephroliths were removed in all the patients. Mean hospital stay was 7 days. In the group of 47 patients intraoperative complications were not observed. Pelvic microperforation (1 case) and loss of the concrement fragment in the paranephria (1 case) were not considered as complications and had no effect on postoperative period and recovery of the patient. Postoperative complications occurred in 6 (12.7%) patients: late hemorrhage (1), pyelonephritis (4), bacteriotoxic shock early after surgery (1). Thus, postoperative infectious-inflammatory complications arose in 5 (10.63%) patients. These patients received the same antibacterial treatment as the other patients except one patient with bacteriotoxic shock in whom a daily dose of tavanik was raised to 1 g in the course of 2 days. As success of transcutaneous nephrolithotripsy depends much on adequate pre- and postoperative antibacterial therapy, tavanik (levofloxacin) can be effectively used as monotherapy in transcutaneous nephrolithotripsy to prevent and treat postoperative infectious-inflammatory complications.
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PMID:[Use of levofloxacin in transcutaneous nephrolithotripsy]. 1791 43

The objective of this study was to evaluate the role of urolithiasis, infection, and bladder dysfunction in the pathogenesis of renal failure in rats subjected to supratrigonal cystectomy. One group of Sprague-Dawley rats was submitted to supratrigonal cystectomy, a second to cystectomy during which a suspension of Proteus mirabilis was injected into the bladder stump, and a third to sham surgery (controls). The animals were sacrificed two months after surgery. Blood pressure and serum urea and creatinine were measured before surgery and at sacrifice when a careful inspection of the urinary tract was performed to determine the presence of hydronephrosis and calculi. Microbiological analyses were performed on urine aspirated from the bladder and on the kidneys. Significant differences were found between values of systolic blood pressure and serum urea and creatinine recorded prior to the surgical procedure and those recorded at sacrifice in each group except the control group. Renal failure was present in all animals subjected to cystectomy. Urinary calculi were documented in 5/10 animals subjected to cystectomy only and in all rats inoculated with P. mirabilis. Hypertension was documented in 43.75% of animals subjected to cystectomy. Pyelonephritis was diagnosed only in animals with urinary calculi, in each of which urine culture was also positive. No cases of renal failure, hypertension, calculi, and/or pyelonephritis were detected in the sham group. The findings of this study indicate that kidney failure in rats subjected to supratrigonal cystectomy is related to the severe bladder dysfunction induced by the surgical procedure.
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PMID:Experimental supratrigonal cystectomy: II--Evaluation of urinary calculi, infection, and bladder dysfunction in the pathogenesis of renal failure. 1808 27

Acute pyelonephritis causes hospitalization and is a commonly-ignored cause of death in geriatric patients. It has been well studied in young-adult populations but rarely in geriatric populations. The aim of our study was to analyze the characteristics of acute pyelonephritis in geriatric patients. The electronic admission records of a community hospital in northeastern Taiwan were retrospectively screened from July 1, 2003 to June 30, 2006. The basic characteristics, laboratory findings and infectious microorganisms of all subjects were evaluated. Sixty-five subjects (mean age 71.6 +/- 4.9 years; range 65-84 years) and 73 admission records contributed by them were enrolled. These 65 subjects, including one who died in hospital, were predominantly female (52 subjects; 80%). Twenty-two subjects (33.8%) had co-existing diabetes mellitus, 9 subjects (13.8%) had co-existing tumors, and 19 subjects (29.2%) had a history of intra-abdominal surgery. The admission records revealed right kidney involvement (52.1%), co-existing urolithiasis (50.7%) and admission to wards of internal medicine (57.5%). Urological procedures were performed on 20 (27.4%) of all 73 admission records. Escherichia coli was the most common infecting microorganism (19.2% of all records; 42.4% of records with positive microorganism culture). Hemoglobin < 10 g/dl was a significant predictive factor for both hospital stay > 7 days and serum creatinine > 2.0 mg/dl (p = 0.003 and 0.002, respectively). Positive microorganism culture was also a significant predictive factor for hospital stays > 7 days (p < 0.001). In our geriatric patients with acute pyelonephritis, low hemoglobin levels implied co-existing renal insufficiency and prolonged hospitalization. Positive microorganism culture also implied prolonged hospitalization.
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PMID:The characteristics of acute pyelonephritis in geriatric patients: experiences in rural northeastern Taiwan. 1821 88


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