Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective comparison of the evidence obtained at preoperative examination of 68 patients with urolithiasis operated with the use of percutaneous technologies has demonstrated that the risk of postoperative infectious-inflammatory complications depends much on the immune status of the patient. Patients with initially different states of phagocytic immunity and antibody production had different courses of the postoperative period. An algorithm of immunological prediction of an acute pyelonephritis attack after percutaneous operations for nephrolithiasis is proposed.
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PMID:[Immunologic assessment of the risk of developing infectious-inflammatory complications after percutaneous operations for nephrolithiasis]. 1187 65

A novel difluoroquinolone drug sparfloxacine has a wide antibacterial spectrum. It is active both against gram-negative and gram-positive flora. Sparfloxacine was tried in 43 patients with pyelonephritis and prostatitis complicated with urolithiasis, diabetes mellitus, nephroptosis, anomalous kidneys, etc. The drug was given according to its pharmacokinetics for 7-14 days in a daily dose 400 mg (day 1) then 200 mg/day. The effectiveness of sparfloxacine in complicated pyelonephritis and prostatitis was rather high: clinical response reached 83.7%, bacteriological one--78.7%.
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PMID:[Effectiveness of sparfloxacin (sparflo) in the treatment of complicated forms of pyelonephritis and prostatitis]. 1189 27

The authors review the effectiveness of a novel fluoroquinolone drug sparfloxacine (Sparflo, Dr. Reddy's Laboratories) in the treatment of patients with complicated forms of pyelonephritis and prostatitis. Both gramnegative and grampositive agents causing complicated urologic infections were highly sensitive to sparfloxacine: Enterobacter spp.--40.8%, Pseudomonas aeruginosa--38.5%, Proteus spp.--42.6%, E. coli--91.4%, Staphylococcus spp.--80.0%, Enterococcus faecalis--21.4%. Sparfloxacine was used in the treatment of 43 patients with complicated pyelonephritis and prostatitis. The complicating factors were the following: urolithiasis, renal anomalies, hydronephrotic transformation, nephroptosis, benign prostatic hyperplasia. Clinical response reached 83.7%; microbiological--78.7%. Thus, sparfloxacin has a wide spectrum of antibacterial activity and can be effectively used in patients with complicated infections of the urinary tract.
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PMID:[Use of sparfloxacin (Sparflo) in treating complicated urologic infections]. 1207 17

Changes in concentrations of total thyroxine (T4) and triiodothyronine (T3) in blood plasma, blood coagulation and prothrombin index (PI) 9 days after exposure to extracorporeal shock-wave lithotripsy (ESWL) were studied in patients with urolithiasis. Urolithiasis patients with chronic pyelonephritis running with non-severe renal pain had often elevated concentrations of T3, T4 and blood coagulation. On day 9 after ESWL plasma concentration of T3 and coagulation decreased while T4 concentration and PI rose. The analysis of 4-year follow-up after ESWL demonstrates that high levels of T4 and PI on day 9 after ESWL may contribute to development of recurrent urolithiasis.
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PMID:[Extracorporeal shock wave lithotripsy and recurrent urolithiasis]. 1218 58

A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emphysematous pyelonephritis (EPN) was diagnosed and immediately treated with antibiotics and CT-guided percutaneous catheter drainage. Cultures of pus and blood yielded Escherichia coli. She received left radical nephrectomy later for the control of persistent sepsis and removal of left renal tumor. The pathology of the tumor was composed of a glandular arrangement of granular cells with the occasional atypism, and renal parenchyma had been totally replaced by RCC. The non-tumor part of the kidney showed chronic pyelonephritis. Five months later, multiple metastases developed. We reported this first uremic case with EPN and RCC, but without diabetes mellitus and urinary tract obstruction. The gas formation may be due to large RCC, which caused impaired tissue perfusion and E. coli infection.
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PMID:Renal cell carcinoma complicated by emphysematous pyelonephritis in a non-diabetic patient with renal failure. 1218 10

In the present study, the data from 216 women with a complicated hydronephrosis of pregnancy who were treated at the Urology Department of the Vilnius City University Hospital between 1992 and 2001 have been subjected by us to a retrospective analysis and to an evaluation of the need for an interventional treatment and of the volume of the latter in the light of the special literature of the last decade of the XX(th) century. Both urologic observation and urologic management are required in the pregnancy hydronephrosis complicated by strong flank pains due to an acute dilatation of the upper urinary tract or by urolithiasis or pyelonephritis. An ultrasonographic investigation is the diagnostic mean of choice. The conservative management (hydration, spasmoanalgetics and antibiotics) gave positive results in 57% of cases, the retrograde stenting of the ureters was carried out in 41% of cases and the percutaneous or open nephrostomy (performed in 3 and 1 patients, correspondingly) in 2% of cases. During the management of the patients with a complicated hydronephrosis of pregnancy, the interdiscipline training of urologists and obstetricians-gynecologists as well as their close collaboration are of decisive importance.
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PMID:[Hydronephrosis in pregnancy: importance of urologic actions and their volume]. 1255 31

236 operative interventions for urolithiasis have been performed in 234 patients. Of them, 187 (79.9%) patients developed complications. Intraoperatively complications resulted from opening of the pleural and abdominal cavities (20 patients, 8.5%) and intraoperative blood loss < 500 ml (19 patients, 8.1%). In one case a nephrectomy was made because of repeated hemorrhage early after the operation. Among the postoperative complications most frequent were acute pyelonephritis (34, 14.5%) and aggravation of renal failure (11, 4.7%). The former demanded extracorporeal detoxication in 9 cases, in the latter hemodialysis was not required. Residual comcrements occurred in 28 (12%) patients. 17 of them had to undergo extracorporeal lithotripsy. Thus, open urological interventions in urolithiasis are now conducted in advanced disease, provoking complications. This raises responsibility of the surgeons who must take maximal preventive measures and use novel technologies in management of the complications.
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PMID:[Complications of open surgical procedures in urolithiasis and their prevention]. 1257 69

Urinary tract occlusion in urolithiasis is a serious complication which provokes an attack of acute obstructive pyelonephritis. The infected urine aggravates this infectious-inflammatory process and endangers bacterial shock. Etiopathogenesis of this shock is outlined and modern approaches to its management are described.
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PMID:[Urinary tract occlusion: a principal cause of some complications of urolithiasis]. 1262 61

The incidence of drug-induced stone disease is 0.44%. A 57-year-old woman with ulcerative colitis presented with obstructive nephropathy and pyelonephritis. She underwent cystoscopy, bilateral retrograde pyelography, and bilateral ureteral stent placement. A 6-cm bladder calculus and two 3-mm right distal ureteral calculi were discovered. Later, cystolithotomy was performed. The stone analysis demonstrated sulfapyridine, a sulfasalazine metabolite. Patients with inflammatory bowel disease can develop urolithiasis owing to acidic urine and low-volume urine production. Patients receiving aminosalicylates are at an increased risk of urolithiasis and may benefit from oral hydration and urinary alkalization.
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PMID:Obstructive nephropathy secondary to sulfasalazine calculi. 1455 Apr 62

We studied 51 patients with true ureterocele (primarily, orthotopic and unilateral--84.3 and 82.3%, respectively) combined with urolithiasis. Mean age of the patients was 41.9 +/- 2.0 years, size of ureterocele--20.7 +/- 1.3 mm and mean concrement area--1.4 +/- 0.2 cm2. In adult patients with orthotopic or heterotopic disease surgery consisted of perforation (n = 5) or dissection of ureterocele wall (n = 38). Endoscopic operations were indicated in small and middle sized ureterocele (less than 30 mm in size), unaffected contractility of terminal ureter, moderate urodynamic disorders of the upper urinary tracts, normal function of the kidney and no pyelonephritis exacerbation. Endoscopic section of ureterocele wall combined with ureterolithoextraction (n = 26), contact ureterolithotripsy using Ho:YAG laser or ultrasound (n = 19). Open surgery (ureterocystoneostomy by Politano-Leadbetter was made in orthotopic ureterocele over 30 mm in size and in marked urodynamic disturbances of the upper urinary tracts (n = 6). At discharge, a complete elimination of the stones in ureterocele patients was 81.6%. Effective use of extracorporeal shock-wave lithotripsy of nephroliths within 2 months after removal of ureterocele raised this percent to 87.7. Thus, choice of surgical policy in ureterocele complicated by urolithiasis depends on its size, variant of combination of this defect with the concrement, anatomofunctional state of the upper and lower urinary tracts, age of the patient and presence of pyelonephritis.
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PMID:[Ureterocele and urolithiasis]. 1502 44


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