Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Coral nephrolithiasis (CN) patients treated surgically in Research Institute of Urology and hospital N 47 from 2005 to 2008 were divided into 5 groups by treatment: PCNL, PCNL+extracorporeal lithotripsy (EL), EL, open interventions, EL of the residual concrements after previous open operations. Most complications were observed after EL and they were caused by evacuation of many fragments. PCNL caused in some cases massive hemorrhage stopped by conservative methods. Open operations can effectively remove concrements in one stage but sometimes entail such severe complications as damage to adjacent organs, pleura or abdomen, hemorrhage, exacerbation or progression of chronic pyelonephritis. Results of combined surgical interventions (PCNL+EL) and EL of residual concrements after open surgery are comparable with those of EL as monotherapy if the schedule of repeat sessions is observed and saving regimens of fragmentation are used.
 ...
PMID:[Surgical treatment of coral nephrolithiasis: analysis of complications]. 2017 78

This case illustrates a rare complication of an impacted ureteric stone which eroded through the wall of the ureter leading to formation of a psoas abscess. Ureteric stent placement and percutaneous drainage of the abscess were insufficient to resolve the problem. Renal scan revealed poor function and the left kidney was removed. It showed evidence of acute supporative pyelonephritis with nephrolithiasis.
 ...
PMID:Psoas abscess from ureteric stone perforation. 2097 40

Squamous cell carcinoma of urinary tract is a rarely encountered tumor. It is more frequently reported in urinary bladder and male urethra than renal pelvis. Squamous cell carcinoma of renal pelvis is usually associated with nephrolithiasis. However, coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis is exceedingly rare with only one case on record so far. We report two such cases detected incidentally in patients who have undergone nephrectomy for hydronephrosis. The post operative histological evaluation revealed unsuspected squamous cell carcinoma of renal pelvis with concomitant xanthogranulomatous pyelonephritis.
 ...
PMID:Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. 2111 70

A total of 151 patients with nephrolithiasis participated in the study of efficacy and safety of the drug prolit cepto in conservative treatment of nephrolithiasis patients, preoperative preparation and in postoperative period after extracorporeal shock-wave lithotripsy (EC-SWL) or nephrolitholapaxy. It was found that combined treatment of nephrolithiasis complicated by secondary pyelonephritis with addition of prolit cepto raises efficacy in management of inflammation due to a positive action on microcirculation and urine bacteria. Administration of prolit cepto in nephrolithiasis patients exposed to EC-SWL or nephrolitholapaxy reduces the risk of infectious and inflammatory complications, has a nephroprotective effect and improves the course of postoperative period.
 ...
PMID:[Combined treatment of patients with nephrolithiasis complicated with secondary pyelonephritis]. 2187 Apr 77

Xanthogranulomatous pyelonephritis (XPN) is a rare inflammatory condition usually secondary to chronic obstruction caused by nephrolithiasis and resulting in infection and irreversible destruction of the renal parenchyma. Its standard therapy consists of total or partial nephrectomy. A case of stage III xanthogranulomatous pyelonephritis treated with antibiotherapy and percutaneous drainage is presented in this paper.
 ...
PMID:Stage III xanthogranulomatous pyelonephritis treated with antibiotherapy and percutaneous drainage. 2198 Jul 41

Primary squamous cell carcinoma (SCC) of the renal pelvis is rare because SCC represents only 0.5% to 0.8% of malignant renal tumors. Chronic irritation, inflammation, and infection induce squamous metaplasia of the renal collecting system, which may progress to dysplasia and carcinoma in most of affected individuals. Nephrolithiasis, especially formation of staghorn calculi, is the most common risk factor for SCC, which usually occurs in older adults (age 50-70 years) with no sex predilection. Clinical features include flank or abdominal mass, weight loss, hematuria, or paraneoplastic syndromes, such as hypercalcemia. Radiologically, SCC of the renal pelvis may appear as a solid mass, hydronephrosis, or calcifications. The radiologic differential diagnosis includes primary and secondary renal neoplasms and xanthogranulomatous pyelonephritis. Squamous cell carcinomas of the renal pelvis are usually large, necrotic, and ulcerated, with gross invasion of the renal parenchyma and perinephric soft tissue. Most SCCs of the renal pelvis are moderately or poorly differentiated and typically present at an advanced stage. Surgical resection and adjuvant chemoradiotherapy are rarely curative. The prognosis is dismal with a 5-year survival rate of less than 10%.
 ...
PMID:Squamous cell carcinoma of the renal pelvis. 2219 51

Idiopathic renal hypouricaemia is an inherited form of hypouricaemia, associated with abnormal renal handling of uric acid. There is excessive urinary wasting of uric acid resulting in hypouricaemia. Patients may be asymptomatic, but the persistent urinary abnormalities may manifest as renal stone disease, and hypouricaemia may manifest as exercise induced acute kidney injury. Here we have identified Macedonian and British patients with hypouricaemia, who presented with a variety of renal symptoms and signs including renal stone disease, hematuria, pyelonephritis and nephrocalcinosis. We have identified heterozygous missense mutations in SLC22A12 encoding the urate transporter protein URAT1 and correlate these genetic findings with functional characterization. Urate handling was determined using uptake experiments in HEK293 cells. This data highlights the importance of the URAT1 renal urate transporter in determining serum urate concentrations and the clinical phenotypes, including nephrolithiasis, that should prompt the clinician to suspect an inherited form of renal hypouricaemia.
 ...
PMID:Clinical and functional characterization of URAT1 variants. 2219 75

A rare case of pan-subepithelial dystrophic calcium deposition and bone marrow formation in hydronephrosis secondary to obstructive urolithiasis is reported and discussed. An elderly gentleman presented with accelerated hypertension, a nonfunctioning left kidney secondary to obstructive nephrolithiasis with additional pancalyceal calcification. His left retroperitoneoscopic nephrectomy specimen revealed sterile hydronephrosis secondary to an impacted ureteropelvic junction stone and pan-subepithelial fibrocalcific lamellar deposition. Special stains confirmed end-stage renal disease with chronic pyelonephritis with subepithelial dystrophic calcium deposition and evidence of bone marrow formation.
 ...
PMID:'Porcelain kidney': case report and review of the literature. 2241 54

Renal infarction is an underdiagnosed and under-reported phenomenon, and needs to be diagnosed rapidly to prevent permanent loss of renal function. Renal infarction should be considered in the initial differential diagnosis of nephrolithiasis and pyelonephritis. It is often mistaken for more benign pathology and is worthwhile reviewing and reporting.
 ...
PMID:Renal infarction. 2296 1

A comparative study has evaluated the effect of fluoroquinolones and beta-lactams on clinical and biochemical manifestations of chronic pyelonephritis (CPN). 108 patients aged from 18 to 59 years (mean age - 40.26 +/- 10.09 years) with secondary CPN against dysmetabolic nephropathy and nephrolithiasis in a phase of active inflammation were observed. The majority of patients were women - 89 (82.4%). CPN was diagnosed in accordance with the N.A. Lopatkin and V.E. Rodoman clinical classification (1974) based on results of complete clinical and laboratory, radiologic and ultrasound examinations. Special methods of investigation included determination of the activity of lipid peroxidation, antioxidant system and the structural parameters of the cell membrane ofpolymorphonuclear leukocytes (PMN). Pain, dysuria, and intoxication syndrome were arrested in all patients after 14 days of therapy. The high efficacy was reported for patients treated with sparfloxacin. A similar trend was observed in the dynamics of intoxication syndrome regression. In addition, there was a significant reduction of lipid peroxidation products and an increase of alpha-tocopherol in the PMN membranes; the content of phospholipids significantly increased and cholesterol level declined during the treatment. The results showed that use of fluoroquinolones and the B-lactams in the treatment of patients with CPN against the nephrolithiasis leads to a significant relief of clinical symptoms of the disease, as well as to restoration the structural and functional state of PMN membranes. The most distinct and early clinical-laboratory effect was obtained against the background of use of fluoroquinolone sparfloxacin.
 ...
PMID:[Comparative effectiveness of fluoroquinolones and beta-lactams in the complex therapy of patients with chronic pyelonephritis]. 2311 15


<< Previous 1 2 3 4 5 6 7 8 9 10