Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The SDS polyacrylamide gelelectrophoresis (SDS-PAA) as used in this study has proven to be an excellent tool to differentiate urinary proteins qualitatively and quantitatively, since the proteins are differentiated exclusively according to their molecular radius. Selectivity was estimated by the ratio transferrin:IgG. Some of the proteins were identified by specific antisera. For clinical use SDS-PAA may distinguish: chronic glomerulonephritis from chronic pyelonephritis; the different diabetic nephropathies; some cases of minimal change nephritis from proliferative and degenerative glomerular diseases; the uncomplicated posttransplantation course from (interstitial) rejection crises and from glomerular diseases (recurrent GN, glomerular rejection disease), and the persisting small glomerular proteinuria after acute glomerulonephritis from proteinurias becoming physiological.
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PMID:Discelectrophoretic molecualr weight analysis of urinary proteins. A contribution to the clinical diagnostic differentiation and the pathophysiology of proteinuria. 123 87

Efficacy of blood UV irradiation (BUVI) followed by its reinfusion to the patient in combination with antibacterial therapy was studied in patients with acute and chronic pyelonephritis and its purulent septic complications. The BUVI was used when the antibacterial drugs failed to be sufficiently efficient and the clinical process of the infection was severe. The kinetics of ferritin, transferrin, alpha 2-macroglobulin, beta 2-microglobulin and haptoglobulin in the blood serum was investigated as a criterion of treatment efficacy. It was shown that the BUVI markedly increased the chemotherapy efficacy. The observed regularities of the changes in the serum antigenic spectrum can be used as a basis for the control of treatment efficacy.
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PMID:[Ways of increasing the effectiveness of chemotherapy of urinary tract infection]. 141 29

Bromadiolone damaged the erythrocytes, resulting in a probable saturation of transferrin, a deposit of iron in the connective tissue and in a few cells of the proximal tubules of the kidneys and an increased storage of ferritin in the spleen. In the hepatocytes, mitochondria were distorted, their lipid inclusions being granular; a large depletion of glycogen may be considered a reflection of an elevated phosphorylase a ascribable to the proliferation of the smooth endoplasmic reticulum. In the kidneys, pyelonephritis may be irrelevant to the poisoning of the animals. Bromine could not be detected using microanalytical methods.
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PMID:[Effects of bromadiolone on some organs and tissues (liver, kidney, spleen, blood) of coypu (Myocastor coypus)]. 190 55

The authors used monoclonal antibodies to human transferrin for the development of a high-sensitive test system for the assessment of transferrin levels in urine with enzyme immunoassay. The conditions of the immunoassay performance were optimized. The sensitivity of the test system enabled the authors to define the levels of transferrin up to 1 ng/ml. Tests for the detection of transferrin in patients with chronic pyelonephritis and chronic renal failure were performed. The designed test system permitted transferrin to be revealed in the urine of those patients who had negative results during a radial immunodiffusion. The authors demonstrated the possibility of using the developed monoclonal antibodies in laser nephelometry for the detection of blood and urinary transferrin levels.
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PMID:[The use of monoclonal antibodies for determining the transferrin content of the urine]. 197 11

Blood serum levels of stage-specific antigens were measured by radioimmunoassay and immunodiffusion methods in patients with acute pyelonephritis at various stages of traditional antibacterial therapy and ultraviolet autoblood irradiation. Under study were ferritin, beta 2-microglobulin, C-reactive protein, transferrin, alpha 2-macroglobulin, and haptoglobin levels. Kinetics of the measured proteins was demonstrated and the possibility of applying their identification to assessment of treatment efficacy shown. The levels of these proteins are shown to be not only indicators of inflammation and destruction in pyelonephritis, but to reflect as well the repair reactions in the body which course most actively when UV irradiation of autoblood is added to multiple-modality treatment schemes.
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PMID:[Serum antigens in the evaluation of the effectiveness of pyelonephritis therapy]. 795 3

Eighty-nine pregnant women, including 62 pregnant females with pyelonephritis, were examined. After bacteriophage treatment for pyelonephritis, there was an increase in the content of iron, a decrease in the level of soluble transferrin receptor without iron therapy, suggesting iron redistribution in pregnant woman. The blood levels of copper, ceruloplasmin, and transferrin in pregnant women with pyelonephritis point to antioxidative defense activation in both healthy pregnant women and pregnant females with pyelonephritis. The serum concentration of ceruloplasmin is of importance for prognosis and evaluation of ceruloplasmin in pregnant women. The higher content of ceruloplasmin in pregnancy is indicative of the involvement of protective mechanisms from autoaggression.
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PMID:[Effect of bacteriophage on the serum level of iron and copper in pregnant women with pyelonephritis]. 1872 Jul 32

We examined the indicators of oxidant/antioxidant (O/A) balance in the blood of, 118 women with chronic pyelonephritis. (PN), aged 18 to 69 years (mean 36.0 +/- 7.9 years) and 30 conventionally healthy donors: 82 (69.5%) of patients had the recurrent PN, 36 (30.5%) of women had the sporadic PN. The malondialdehyde in serum, ceruloplasmin, transferrin and the number of sulfhydryl groups, which allowed to calculate the index of oxidative stress (IOS) were included into the complex research of O/A balance. IOS was significantly increased in patients with recurrent PN 4.27 2.06 vs. 2.30 +/- 1.06 for sporadic PN (P < 0;001). It allowed us to conduct the multivaiate analysis using binary logistic regression. The analysis demonstrated alhigh quality (>80 %) of regression model chi2 = 74.3; P < 0.001, odds ratio (OR) = 7.5, 95% CI 3.3-7.1. We have created an additional examinational sample to confirm the adequacy of this model which included the test results of 23 pa- tients with acute PN in 6 (26%) of them have developed recurrent PN. We defined a high quality of examinational model chi2 = 11.2; P = 0.0008, OR =3.34, 95% CI 1.3-10.3. The optimal criteria for IOS was > 3, sensitivity 100%, and for specificity 94%. Thus, for the prediction of recurrent PN can be evaluated the IOS. The development of recurrent PN can be predicted with probability 97.6% if value of IOS > 2.5; this will optimize the rehabilitation program of patients Vith acute PN.
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PMID:[PREDICTION OF RECURRENT PYELONEPHRITIS BY AN INDEX OF OXIDATIVE STRESS]. 2649 81

Metabolic disturbances were corrected using the oral specialized formula Nutrien-phthisio (ZAO "Company Nutritec", Russia) in 53 patients with pulmonary tuberculosis and concomitant diseases. In the whole group, tuberculosis was first detected in 21 patients; 32 had a chronic process. Chemotherapy was discontinued in all the patients due to the intolerance phenomena caused by comorbidity (erosive gastritis, gastroduodenal peptic ulcer, hepatitis B and C, chronic pyelonephritis) in 24 patients, by adverse reactions in 19, and by a combination of both factors in 10. The criteria for objectively monitoring the efficiency of nutritional support (in combination with specific treatment) were body mass index, general blood analysis, by taking into account the percentage and absolute count of lymphocytes and the protein metabolism from the serum levels of total protein, albumin, and transferrin. The study determined clinical and laboratory indications for the use of Nutrien-phthisio and the favorable impact of nutritional support on the course of a tuberculous process and concomitant diseases.
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PMID:[CORRECTION OF METABOLIC DISTURBANCES IN PATIENTS WITH PULMONARY TUBERCULOSIS AND CONCOMITANT DISEASES]. 2752 44