Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anaerobic bacteria were recovered from 5 children with urinary tract infection (UTI). Three had pyelonephritis and 2 cystitis. Two of the patients had a history of prior recurrent UTI. Urine samples were collected using suprapubic aspiration. The anaerobic organism recovered were 3 isolates of Bacteroides fragilis and one each of B. melaninogenicus, Peptococcus asaccharolyticus, and Bifidobacterium adolescentis. Mixed infection was present in 3 children. In 2 cases B. fragilis were present with Escherichia coli, and in the other case two anaerobes were present. All patients were treated with antimicrobial agents for ten to fourteen days and responded well to therapy. Two of the children had a recurrence of UTI with aerobic organisms recovered from their urine within six to eight months. This report demonstrates the association of anaerobic organisms with UTI in children. It is suggested that cultures for anaerobic organisms be performed in symptomatic children whose aerobic cultures show no bacterial growth.
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PMID:Urinary tract infection caused by anaerobic bacteria in children. 744 6

Mixed urinary tract infection was caused by simultaneous inoculation of 10(4) CFU each of Enterococcus faecalis TN2005 and Pseudomonas aeruginosa P9 into the bladders of CBA/J mice. Both organisms proliferated in the kidneys, and viable cell counts of E. faecalis TN2005 reached a peak level of 4.1 x 10(5) CFU per pair of kidneys within the first 24 h, while P. aeruginosa P9 counts increased more slowly. The number of P. aeruginosa P9 cells peaked at 8.3 x 10(6) CFU per pair of kidneys 5 days after infection. Five days after mixed infection, infiltration of neutrophils into the renal pelvis and renal medulla was observed. Immunohistochemical staining revealed the presence of E. faecalis antigen in the renal medulla. P. aeruginosa antigen was detected mainly in the renal pelvis 5 days after infection and in the renal medulla as well as the renal pelvis 14 days after infection. Mixed infection induced pyelonephritis within 5 days after mixed infection, while it was not observed until 14 days after infection with P. aeruginosa P9 alone. P. aeruginosa P9 inoculated together with E. faecalis TN2005 was more resistant to eradication from the kidneys by beta-lactam antibiotics than P. aeruginosa P9 inoculated alone. These results suggest that E. faecalis TN2005 invades the renal medulla first in mixed urinary tract infection and induces histological changes which lead to aggravation of the pyelonephritis caused by P. aeruginosa P9.
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PMID:Enterococcus faecalis aggravates pyelonephritis caused by Pseudomonas aeruginosa in experimental ascending mixed urinary tract infection in mice. 792 19