Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Proportions and total numbers of peripheral blood T and B lymphocytes as well as their activity measured in the leukocyte migration inhibition test were estimated in 47 patients with acute or chronic glomerulonephritis and in 30 individuals serving as a control group. The obtained results indicated that glomerulonephritis was associated with altered proportions of peripheral blood lymphocytes. In acute glomerulonephritis high B lymphocyte levels were found while chronic proliferative glomerulonephritis was characterized by high proportions and high absolute levels of T lymphocytes. Few months observation of T: B lymphocyte proportions during the disease indicated that exacerbation of the disease was associated with lowered proportions of T lymphocytes. Moreover, it was shown that cell mediated hypersensitivity to GBM antigens was detectable in 80% patients with glomerulonephritis and was absent from patients with pyelonephritis. The latter results indicate participation of cell-mediated hypersensitivity in pathomechanisms of glomerulonephritis in most of the patients.
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PMID:Cell-mediated hypersensitvity in glomerulonephritis. 31 32

The authors established macroscopic hematuria in 13,8 per cent of the examined 1618 renal patients. It is most often met in patients with chronic calculus pyelonephritis and nephrolithiasis (45,2%). In 9,0 per cent of the patients with chronic glomeruloneshrihs and in 14,9 per cent of those with acute glomerulonephritis the painless macroscopic hematuria is the initial clinical manifestation of the disease. The latter is a frequent symptom (40,6%) in patients with congenital kidney anomalies. In 5,8 per cent of the patients with macroscopic hematuria -- the reason is not elucidated.
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PMID:[Clinical importance of macroscopic hematuria]. 122

The SDS polyacrylamide gelelectrophoresis (SDS-PAA) as used in this study has proven to be an excellent tool to differentiate urinary proteins qualitatively and quantitatively, since the proteins are differentiated exclusively according to their molecular radius. Selectivity was estimated by the ratio transferrin:IgG. Some of the proteins were identified by specific antisera. For clinical use SDS-PAA may distinguish: chronic glomerulonephritis from chronic pyelonephritis; the different diabetic nephropathies; some cases of minimal change nephritis from proliferative and degenerative glomerular diseases; the uncomplicated posttransplantation course from (interstitial) rejection crises and from glomerular diseases (recurrent GN, glomerular rejection disease), and the persisting small glomerular proteinuria after acute glomerulonephritis from proteinurias becoming physiological.
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PMID:Discelectrophoretic molecualr weight analysis of urinary proteins. A contribution to the clinical diagnostic differentiation and the pathophysiology of proteinuria. 123 87

Echography was employed to examine 94 children with different renal pathology. 45 children had chronic secondary pyelonephritis in the presence of the vesicoureteral reflux, 18 hydronephrosis, 14 ureterohydronephrosis, 6 chronic non-obstructive pyelonephritis, 5 acute glomerulonephritis, and 6 chronic glomerulonephritis. The data obtained by ultrasonography and x-ray data were studied and compared. The results thus derived supplement and make it possible to review the former ultrasonic criteria for normal and pathological conditions with unmarked morphological alterations in the kidneys. Novel criteria for the size of the lumen of the collecting systems are presented.
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PMID:[Diagnostic value of renal echography in children]. 219 Jan 69

Serum gamma-glutamyltranspeptidase (GGTP) and alpha-amylase clearance were determined in a total group of 90 patients of whom 60 with renal diseases and 30 with extrarenal diseases. The renal patients were distributed, according to diagnosis in the following groups: acute glomerulonephritis, chronic glomerulonephritis, acute pyelonephritis, chronic pyelonephritis, nephrotic syndrome and manifest chronic renal failure. The 30 controls were hospitalized for different extrarenal diseases such as: pneumonia, gastroduodenal ulcer, arterial hypertension stage I and angina pectoris. Serum GGTP assay was performed in 60 patients (40 renal patients and 20 controls) using Boehringer monotest kits and in 30 patients (20 renal patients and 10 controls) using Romanian kits (I.C.C.F.). No changes suggesting a particular type of nephropathy were observed. The results obtained by using the two types of kits for the serum GGTP assay have proved to be very close. Alpha-amylase clearance was determined in all the patients with Spofa (R.S.C.) tablets concomitantly with the urea and creatinine clearance. Important decreases of alpha-amylase clearance in concordance with decreases of urea and creatinine clearances were observed in all the patients with severe renal failure. More moderate decreases of alpha-amylase clearance were observed in the patients with acute and chronic glomerulonephritis. The utility of this clearance as a test of glomerular filtration and sometimes as a prognostic test, is discussed.
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PMID:Preliminary clinical and methodologic observations on the determination of serum gamma-glutamyltranspeptidase and of the alpha-amylase clearance in nephropathies. 286 37

Nifedipine is a calcium-antagonist whose principal action is reduction of peripheral resistance. The utilization of nifedipine is still limited in infancy. We have studied the immediate effect on hypertensive blood pressure values of nifedipine administered sublingually in 10 children (3 males and 7 females; aged 6-14 years) with different clinical diagnoses: acute glomerulonephritis (6 cases), lupus erythematosus systemicus (2 cases), membrane proliferative glomerulonephritis (1 case), pyelonephritis secondary to vesico-ureteral reflux (1 case). Nifedipine (0.25-0.50 mg/Kg) lowered systolic and diastolic blood pressure values from 167.5 +/- 19.8 mmHg and 103.5 +/- 18.4 mmHg to 126 +/- 19.8 mmHg and 81.5 +/- 15.1 mmHg, respectively, 30 minutes after administration (p less than 0.001). We propose nifedipine as a simple, effective and safe alternative drug for managing hypertensive emergencies in childhood.
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PMID:[Nifedipine in hypertensive emergencies in children]. 383 54

On the assumption that increased urinary lysozyme concentration (;lysozymuria') indicates tubular proteinuria and therefore impaired tubular function, urinary lysozyme has been estimated in acute disorders where transient disturbances of renal function might be expected, in cases diagnosed clinically as extrarenal uraemia, and in a few examples of acute renal disease. Reversible lysozymuria occurred with hypokalaemia, postoperative ;collapse', electrolyte depletion, severe extrarenal infection, acute pyelonephritis, the nephrotic syndrome, after a few apparently uncomplicated surgical operations, and very transiently after ventricular fibrillation abolished by DC shock. There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis. Although lysozymuria may occasionally be useful in the clinical diagnosis of acutely disordered renal function, the results suggest that its value is limited; on the other hand, they have provided information on renal pathophysiology in acute disease.
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PMID:Lysozymuria and acute disorders of renal function. 470 97

Nifedipine caused acute, reversible deterioration in renal function in four patients with chronic renal insufficiency. The absence of hypotension, clinical course, benign urinary sediments, and normal results of renal ultrasound examinations excluded acute tubular necrosis, pyelonephritis, interstitial nephritis, obstructive uropathy, and acute glomerulonephritis. It is postulated that this slow calcium channel blocker produced deleterious intrarenal hemodynamic alterations in the setting of moderate to severe renal functional impairment. Nifedipine may alter renal function by blocking calcium entry into renal vascular smooth muscle, thereby reducing the efficacy of vasoconstrictor hormones in regulation of renal blood flow and glomerular filtration rate. An alternative explanation is that nifedipine may inhibit the compensatory synthesis of vasodilatory prostaglandin E2 analogous to the clinical observation of acute deterioration in renal function by nonsteroidal anti-inflammatory drugs in patients with pre-existing renal insufficiency. These observations suggest that clinicians should monitor renal function closely and exercise caution when administering nifedipine to patients with underlying renal insufficiency.
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PMID:Nifedipine-induced renal dysfunction. Alterations in renal hemodynamics. 649 46

The participation of cell-mediated mechanisms in renal disease is reviewed. Experimental studies demonstrate that delayed-type hypersensitivity reactions can be elicited in the renal interstitium or in the glomerulus and produce lesions characterized by an influx of mononuclear cells and tissue damage. Methods for the analysis of cell-mediated reactions in tissue sections, especially those using monoclonal antibodies, are reviewed, and the possible role of cell-mediated mechanisms in human renal diseases is assessed. It seems probable that cell-mediated mechanisms are involved in the pathogenesis of certain forms of tubulointerstitial and glomerular disease, in particular, drug-induced acute interstitial nephritis, pyelonephritis, anti-GBM nephritis, and certain forms of acute glomerulonephritis. Conclusive evidence awaits, however, the development of techniques that permit identification of cell-mediated reactions in vivo.
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PMID:Cell-mediated mechanisms in renal diseases. 675 Feb 11

A method of radioimmunologic quantitation of antibodies to streptococcal antigen separated from the cell wall extract of group A type T12 strain has been developed. The highest values of radioactive antigen binding were observed in acute glomerulonephritis (75%), as compared to chronic glomerulonephritis in which values of 25% to 56% were found depending on the morphology of renal changes. It was shown that none of the patients with pyelonephritis, Alport's syndrome, lupoid nephritis and polycystic renal disease had elevated antistreptococcal antibody levels. In contrast to this, all patients with tonsillitis and proteinuria exhibited increased titre of this antibody. It was shown that the antigen is related neither to M-protein nor to group A polysaccharide and that it is not type-specific because the binding of antigen T12 may be inhibited by the antigen produced from strain T5. Although the antigen is not type-specific, some differences in the response to antigens prepared from various types of streptococci in patients with different forms of chronic glomerulonephritis are observed.
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PMID:Use of radioimmunoassay for the detection of circulating antistreptococcal antibody in patients with glomerulonephritis. 703 91


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