Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the Clq solid-phase radioimmune assay. Increased Clq-binding activity (Clq-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chronic glomerulonephritis (GN). A significant decrease of Clq-BA immediately after transplantation could not be found. 6 weeks after transplantation only 2 patients of the PN group showed increased Clq-BA. Serial studies in 17 patients with rejection crises did not show any correlation between the level of serum Clq-BA and the occurrence of rejections. Furthermore, no correlation could be found between the occurrence of complement-dependent lymphocytotoxic antibodies measured by the 51Cr release technique and the level of serum Clq-BA. In contrast, our results show that the probability of graftectomy or graft failure is significantly higher, at least in the early phase after transplantation, when the serum Clq-BA is lowered for several weeks.
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PMID:Circulating immune complexes after cadaver kidney transplantation. 702 20

A method of radioimmunologic quantitation of antibodies to streptococcal antigen separated from the cell wall extract of group A type T12 strain has been developed. The highest values of radioactive antigen binding were observed in acute glomerulonephritis (75%), as compared to chronic glomerulonephritis in which values of 25% to 56% were found depending on the morphology of renal changes. It was shown that none of the patients with pyelonephritis, Alport's syndrome, lupoid nephritis and polycystic renal disease had elevated antistreptococcal antibody levels. In contrast to this, all patients with tonsillitis and proteinuria exhibited increased titre of this antibody. It was shown that the antigen is related neither to M-protein nor to group A polysaccharide and that it is not type-specific because the binding of antigen T12 may be inhibited by the antigen produced from strain T5. Although the antigen is not type-specific, some differences in the response to antigens prepared from various types of streptococci in patients with different forms of chronic glomerulonephritis are observed.
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PMID:Use of radioimmunoassay for the detection of circulating antistreptococcal antibody in patients with glomerulonephritis. 703 91

Chronic renal failure associated with hypercalcemia and hypophosphatemia was diagnosed in 6 horses. The renal lesions in 5 of the horses were classified as chronic glomerulonephritis and in the sixth, as chronic interstitial nephritis/pyelonephritis. There was no evidence of primary hyperparathyroidism or pseudohyperparathyroidism, thus suggesting that hypercalcemia associated with advanced renal failure in horses is related to a unique role of the equine kidney in calcium homeostasis.
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PMID:Paradoxic hypercalcemia and hypophosphatemia associated with chronic renal failure in horses. 706 1

The frequency and degree of circulatory insufficiency depending on the stage of the disease are analyzed in 404 patients with chronic glomerulonephritis and 145 patients with chronic pyelonephritis aged 15 to 74 years. When the renal function is still preserved different degrees of circulatory insufficiency are diagnosed in 29.4% of patients. Circulatory insufficiency complicates more often chronic glomerulonephritis than pyelonephritis and is more common in the aged. Latent cardiac insufficiency is more common. In the period of chronic renal insufficiency cardiac decompensation is seen in 78.1% of cases, its frequency is practically the same in glomerulonephritis and pyelonephritis. The mechanisms of development of cardiac insufficiency and the principles of treatment depending on the functional state of the kidneys are discussed.
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PMID:[Circulatory failure in chronic glomerulo- and pyelonephritis]. 712 Jul 48

In 130 patients with chronic pyelonephritis and 215 patients with chronic glomerulonephritis the serum lysozyme content was established and in 114 and 186, respectively, the enzyme content of their urine tests. Moreover the lysozyme measurement in the serum of 28 patients undergoing haemodialysis was performed. A collective of 50 healthy persons served as comparative group. The lysozyme estimation was performed by means of the agar-diffusion technique after Ossermann and Lawlor in own modification. The average serum lysozyme levels of the patients with pyelonephritis (mean =7.3 micrograms/ml) as well as of the patients with glomerulonephritis (mean = 5.7 micrograms/ml) were significantly increased in contrast to the control group (mean = 4.5 micrograms/ml). Differences could be recognized between the various forms of glomerulonephritis. 34.2% of the patients with pyelonephritis and 37.1% of the patients with glomerulonephritis showed a lysozymuria. In functional restrictions of the kidneys as well as in active forms of the diseases increased concentrations in serum and urine could be established.
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PMID:[Serum and urine lysozyme in chronic pyelonephritis and chronic glomerulonephritis]. 726 23

One hundred and twenty-five arteriovenous fistulas for chronic hemodialysis are reviewed and their patency is related to the etiology of terminal uremia and other factors. A significant difference was found between the patency of fistulas of patients with chronic glomerulonephritis (CGN) and those of patients with chronic pyelonephritis (CPN). The average number of A-V fistulas in the CGN group was 1.30, while in those with CPN, 2.14 fistulas per patient necessitated construction. A pattern similar to that of the CGN group was observed in a third group of patients, who had an unclear diagnosis. The average number of fistulas was the same, and the mean survival 20 months in both groups, compared with the four months mean survival in the CPN group. Higher blood pressure levels were observed in the groups with a higher patency rate. The survival of patients with A-V fistulas appears to be related more directly to the etiology of the terminal uremia and care taken during hemodialysis than to the type of vascular connection. Anticoagulation and larger anastomoses are advisable in patients with increased risk of fistula deterioration. These patients should be included in the transplantation priority list.
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PMID:Terminal uremia and arteriovenous fistula patency. 731 37

A 3-year survey of patient referrals and case material in pediatric nephrology is evaluated to provide a data base for future projection of patient needs. In the 3-year period between January 1978 to December 1980, 538 pediatric patients with renal and electrolyte disorders were evaluated and treated. The principle reasons for the referrals were: hematuria (23%), hypertension (5%), nephrotic syndrome (7%), non-acute glomerulopathies (11%), acute glomerulonephritis (3%), fluid-electrolyte disorders (29%), urinary tract infections (6%), and others. Of the 538 patients, 99 underwent percutaneous renal biopsies under ultrasound guidance. The indications and results of the renal biopsies were also reviewed. The accrual of 18 chronic dialysis patients over a 36-month period is analyzed and presented. The ages of the patients were 4 to 16 years. They weighed from 16 to 51 kg. The primary renal diseases were objective uropathy, chronic glomerulonephritis, membrano-proliferative nephritis, chronic pyelonephritis, focal glomerulonephritis, lupus nephritis and others. All children, except 9 received kidney transplantations. The annual incidence of end-stage renal failure was 4 per million population.
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PMID:A 3-year survey of referral pattern and case material in pediatric nephrology. 734 35

A.S.O. titers were determined in 93 children with various kidney diseases. In addition, 52 children without renal disorders were investigated as controls. In the children with renal disease, 38 suffered from the "idiopathic", "primary" nephrotic syndrome of childhood. Thirteen had acute, post-infectious glomerulonephritis, 16 had "primary" chronic glomerulonephritis, 3 had pyelonephritis, and 1 had disseminated lupus nephritis. In acute glomerulonephritis, with or without N.S., the titers were higher than in the controls, which is known and consistent with the frequency of preceding streptococcal infections. Children with chronic glomerulonephritis, with and without associated N.S., did not show a similar tendency to increased values. All patients but one with "primary", , "idiopathic" N.S. of childhood had titers of less than 100. They were between 50 and 12 Todd units. These titers were observed early during the course of the disease and persisted for years in spite of remissions. They were not related to concomitant antimicrobial therapy, nor to corticosteroid administration. In "idiopathic" nephrotic syndrome of childhood a titer of less than 100 does not, in itself, lead to the diagnosis of a N.S. of childhood. However, a greater than 100 titer speaks against it and may well serve as a valid indication for a renal biopsy, in order to differentiate this disease from acute glomerulonephritis, and also from R.P.G.N. whenever they are associated with a N.S. The low titers are only of value in differentiating the "primary" form of the N.S. from the "secondary" forms which are preceded by chronic renal disease or which are due to another underlying, systemic disease. In nephrotic children less than 6 years of age, the less than 100 A.S.O. titers may also be due to their age.
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PMID:Value of antistreptolysin "O" titers for differential diagnosis of renal diseases. 734 28

The C3 polymorphism phenotypes were determined by high-voltage agarose gel electrophoresis in 83 patients with chronic uremia on maintenance hemodialysis. In 45 patients with chronic pyelonephritis, the frequency of C3F and C3FS was significantly lower than in 38 patients with chronic glomerulonephritis and in a large control group.
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PMID:C3 polymorphism in patients with chronic uremia. 735 88

The changes in the number of active ecrine glandulae sudoriferae were studied in 66 patients with diffuse renal diseases, prior to and post stimulation by acentylholine and adrenalin. The same studies were conducted with 20 healthy subjects. The results obtained, show that the average number of the active glandulae suboriferae is higher, with a statistical significance, in patients with chronic pyelonephritis and chronic glomerulonephritis as compared with the healthy subjects. In case of local stimulation with acetylcholine, the number of the activated glandulae sudoriferae was increased to a lesser extent as compared with the healthy subjects, suggesting a reduced cholinergic activity of glandulae sudoriferae. In case of a local adrenalin stimulation, greater increase of the number of the activated glandulae sudoriferae was established as compared with the healthy subjects, suggesting a tendency to intensified adrenergic activity of the glandular sudoriferae.
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PMID:[Changes in sweat secretion in kidney diseases]. 739 86


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