Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

N-acetyl-beta-glucosaminidase (NAG) activity, the concentrations of microalbumin (MA) and B2-microglobulin (B2-MG) were measured in urine of 50 healthy subjects and 200 patients suffering from arterial hypertension (AH) with preserved renal function, including patients with essential hypertension (EH), stages I and II, chronic pyelonephritis (CPN), chronic glomerulonephritis (CGN) and vasorenal hypertension (VRH). The healthy subjects, the patients with stage II EH, and those with secondary forms of AH demonstrated significant differences in NAG activity in urine. A positive correlation (r = +0.53; p < 0.03) was discovered between systolic AP and NAG activity in urine of EH patients. The concentration of MA in urine of CGN and VRH patients was significantly higher than that in the healthy subjects, EH and CPN patients. The patients with CPN and VRH showed significantly higher levels of B2-MG in urine.
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PMID:[The significance of microproteinuria for the diagnosis of kidney involvement in hypertensive disease and secondary forms of arterial hypertension]. 144 Mar 4

Felodipine, a dihydropyridine calcium antagonist, was used to treat eight patients with severe uncontrolled hypertension: five had essential hypertension, two had renovascular disease, and one chronic pyelonephritis. Mean blood pressure (BP) was 221 +/- 14/120 +/- 4 mm Hg despite treatment with three or more antihypertensive drugs. All patients experienced an immediate and pronounced lowering of BP after adding felodipine, which persisted during long-term treatment in combination with previous medication except for vasodilating drugs. In all cases, an increase in glomerular filtration rate (51Cr-EDTA clearance) after 6 and 12 months of felodipine treatment was seen (59 +/- 10 to 63 +/- 7 and 70 +/- 6 ml/min, respectively, p less than 0.05). Renal plasma flow (PAH clearance) exhibited only a slight increase (315 +/- 68 to 340 +/- 63 and 314 +/- 69 ml/min), giving a nonsignificant rise in filtration fraction (18 +/- 1 to 21 +/- 1 and 20 +/- 1%, respectively). It is concluded that felodipine decreases BP dramatically in patients with previously refractory hypertension and that the drug causes an improved renal function in these patients.
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PMID:Long-term effects of felodipine on blood pressure and renal hemodynamics in severe hypertension. 169 10

++Non-ezymatic lipid peroxidation (LP) and total lipids (TL) in serum and erythrocytic membranes were studied in 42 hypertensive subjects and 35 chronic sufferers with pyelonephritis accompanied by arterial hypertension. The measurements performed at different phases of the clinical course provided evidence in favour of possible application of LP and TL tests in differentiating essential hypertension from chronic pyelonephritis with arterial hypertension.
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PMID:[Lipid peroxidation in patients with hypertension and chronic pyelonephritis with arterial hypertension]. 208 29

The evaluation of hormonal adaptation of the fetoplacental unit (FPU) in pregnant women with somatic and obstetric complications has demonstrated 4 patterns of adaptation: normal, stressful, maladaptive and unstable. The distribution of FPU adaptive responses across diagnostic groups correlated with types of diseases and their duration in pregnant women. Controlled heart diseases, chronic pyelonephritis without exacerbations, mild toxemia were mostly associated with a normal FPU adaptation. Decompensated heart disease, acute episodes of chronic pyelonephritis, deteriorating toxemia, decompensated diabetes mellitus produced functional activation of FPU hormones. Pregnant women with stable hypertension in the presence of moderately severe toxemia and essential hypertension showed hormonal FPU maladaptation. Differential evaluation of FPU adaptation in pregnant women with somatic and obstetric diseases provides a guide to a range and sequence of interventions for fetal disorders.
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PMID:[Hormonal diagnosis of fetal adaptation disorders in pregnant women with extragenital and obstetric pathology and the principles of their correction]. 208 91

The rate of Na-Li countertransport was studied in inpatients with essential hypertension (n = 59), chronic diffuse glomerulonephritis (n = 30), chronic pyelonephritis (n = 26), renovascular hypertension (n = 15) and in those with associated renovascular hypertension and essential hypertension (n = 4). Multiple regression analysis has demonstrated that age, body weight and blood plasma lipids do not make any significant contribution to dispersion of the counter transport rate. The mean rate of countertransport in patients with essential hypertension turned out much higher than that in patients with secondary hypertensions. Repeated examinations have shown that in every man, the countertransport rate remains unchanged for 1.5 yr. It is not affected either by hypotensive therapy or surgical treatment. In inpatients with secondary hypertension and low rates of countertransport, high arterial pressure (AP) drops after surgical treatment of the kidneys, renal vessels or adrenals. Surgical treatment of patients with secondary hypertension and high rates of countertransport does not lead to any material decrease of AP. It is assumed that the rate of Na-Li countertransport can be used for diagnosing associated secondary hypertensions and essential hypertension and prediction of AP lowering after surgical treatment.
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PMID:[Na-Li countertransport and the diagnosis of hypertension and combined hypertension and renal artery stenosis]. 221 10

Differential diagnosis between essential hypertension and secondary arterial hypertension (AH) that developed in the presence of chronic pyelonephritis was made in 12 patients with AH and the urinary syndrome (leukocyturia and bacteriuria). With that purpose in view for revealing functional renal asymmetry, a study was made of the effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in each kidney separately based on computation of 99Tc-DTPA and 131I-hippuran clearances. Some patients in whom AH was later regarded as essential manifested practically equal values of the ERPF and GFR from both sides, with the real characteristics of the latter ones being little different from the respective populational values calculated by computer bearing in mind the body surface of those patients. The other patients' group showed, along with a decrease of the total ERPF and GFR, a dramatic asymmetry of the intrarenal hemodynamics of both ERPF and GFR, which is fairly characteristic of chronic pyelonephritis. This allows the syndrome of AH to be regarded in those patients as secondary.
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PMID:[The determination of the separate intrarenal hemodynamics and its place in the diagnosis of nephrogenic arterial hypertension]. 221 11

Organization of the management of outpatients with a transplanted kidney is described. The basis of such organization is formed by documentation of the patients' status during the entire observation period in a special card containing the data on the donor; distant monitoring of cyclosporin A for patients living far from the clinic; training of patients. The main complications that occur in patients with a transplanted kidney in the long-term postoperative period are related. They are pyelonephritis of the transplant, essential hypertension and symptomatic hypererythrocytosis. The 2-year survival of the patients is 70.8%, that of the transplant 73.1%.
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PMID:[The outpatient management of patients with a transplanted kidney]. 221 38

Serum levels of plasma-derived toxic protein components, the median weight molecules (MWM), have been assayed in 206 women with third-trimester pregnancy and in their newborns. Toxemia of various severity was present in 194 women and had developed in the presence of an extragenital disease in 84.2% (pyelonephritis, glomerulonephritis, essential hypertension, etc.). Concentrations of MWM were found to increase with deterioration of renal function and to correlate with severity of nephropathy. In every second pregnancy with toxemia, interventions included extracorporeal detoxication: ultraviolet-irradiated blood autotransfusion (UIBA) and hemosorption. The rates of intra- and postpartum complications or requirement for surgery were 1.5-2-fold lower in these patients, and their newborns has better neonatal progress. Perinatal mortality of these patients was two times as low as that in the rest of the population (31.9:1000 versus 62.6:1000). The use of UIBA is recommended for mild and moderate toxemia and in combination with hemosorption for severe nephropathy.
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PMID:[The role of middle-weight molecules in the pathogenesis of late pregnancy toxemia]. 222 Dec 67

A prospective study involving 1,980 patients aimed at defining the pathological basis of endstage (chronic) renal failure in Nigerians was carried out over a six-year period in Benin City, Nigeria. Using information derived from intravenous pyelography, ultrasonography, renal biopsies and autopsies, it was found that 43% of cases of chronic renal failure were due to hypertensive nephrosclerosis, 33% due to obstructive uropathy and 18% due to chronic glomerulonephritis. Chronic atrophic pyelonephritis was a rare finding. The frequency and severity of essential hypertension in Nigerians and their propensity to go into renal failure are similar to what obtains in American blacks. In a society which cannot afford regular dialysis and transplant facilities, there is need for early detection and adequate treatment of essential hypertension.
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PMID:The pathological basis of endstage renal disease in Nigerians: experience from Benin City. 227 31

The authors described the principle and algorithms of the separation of a summary radionephrogram into constituents, reflecting the contribution of a radiopharmaceutical, uptaken by neutrons, and RP in the surrounding tissues. The authors proposed a correct method for estimation (using the first constituent) of the efficacy indicator of RP uptake by the kidneys (Q-parameter) and the indicator of the mean time of transit (t) in the kidneys of RP uptaken by their parenchyma. The results of testing of the proposed methods of Q and t calculation were presented. Values of these parameters were determined in health and in essential hypertension, I and II degree, pyelonephritis, chronic nephritis (latent and hypertensive types), stenosis of the renal artery, obstruction of the upper urinary tracts, and in one kidney. These results indicate the physiological adequacy of the employed mathematical models, proving the diagnostic informative value of the calculated indicators.
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PMID:[The isolation of the contribution of the parenchyma to the radionephrogram and the assessment of kidney purifying function]. 237 81


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