Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vesicoureteral reflux and chronic pyelonephritis are usually associated with proteinuria of less than 1 gm. per 24 hours. When there is massive proteinuria an associated glomerulopathy is usually present. We describe a patient who had nephrotic syndrome with radiological evidence of ureterovesical reflux and histological evidence of chronic pyelonephritis without associated glomerulonephritis.
 ...
PMID:Nephrotic syndrome secondary to chronic pyelonephritis and ureterovesical reflux. 124 1

The term "renal osteodystrophy" is used to include skeletal disorders of patients with chronic renal failure: osteitis fibrosa, osteomalacia, osteosclerosis, osteoporosis and the frequently associated extraskeletal calcifications. It is the chronic glomerular disease with phosphate retention and resultant hyperphosphatemia on one hand and deficient 1,25 (OH)2 D3 and resultant hypocalcemia on the other to induce secondary hyperparathyroidism. The three most common causes of chronic renal failure in our patients are chronic glomerulonephritis, diabetic nephropathy, hypertensive nephropathy in decreasing frequency, polycystic renal disease occurs in five patients. Other miscellaneous causes include nephrotic syndrome, chronic pyelonephritis, systemic lupus erythematosus, periarteritis nodosa, interstitial nephritis and renal stones. The bone changes are similar in primary and secondary hyperparathyroidism and the incidence of brown tumor is about 3% in the former and 1.5 to 1.7% in the latter. We present one among the 94 dialyzed patients who has long-standing severe chronic renal failure from polycystic kidney disease and develops brown tumor in the mid ulna after 7 years on maintenance hemodialysis. The incidence of brown tumor in our series is about 1.1%. Because of increased longevity of the dialyzed patients, brown tumor from secondary hyperparathyroidism is now more commonly observed. Hyperphosphatemia with serum calcium-phosphate products exceeding plasma solubility of 60 to 75 mg/dl may induce soft tissue and vascular calcification. This explains the much higher incidence of soft tissue calcification in secondary than primary hyperparathyroidism; two of our patients with generalized Monckeberg's type arterial calcification and multiple periarticular calcifications in five patients have been observed.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Renal osteodystrophy. 164 77

The association of xanthogranulomatous pyelonephritis and systemic amyloidosis is extremely rare. To our knowledge, despite innumerable cases of xanthogranulomatous pyelonephritis reported in the literature, this association has been described on only 2 occasions. Clinical, analytical and radiographic findings can be highly suggestive of the diagnosis. We report on 2 patients with xanthogranulomatous pyelonephritis, systemic amyloidosis and the nephrotic syndrome: 1 died 4 1/2 years after diagnosis and 1 was stable with good general health 3 years after diagnosis. The clinical aspects as well as the treatment given to both patients are discussed. We describe the natural history of an association that due to its rarity is not currently well known.
 ...
PMID:Xanthogranulomatous pyelonephritis and systemic amyloidosis: report of 2 new cases and the natural history of this association. 194 52

Analysis of the data obtained during a comprehensive examination of a great number of nephrologic patients during 1964-1989 permitted the author to draw a conclusion that a considerable part of errors in the diagnosis of diffuse renal lesions (DRL) are primarily made as a result of inadequate choice of examination methods that might contribute to the solving of a diagnostic problem; an insufficiently clear idea of the resolving power of those methods, and violation of the succession of their use. Erroneous interpretation of the patient's complaints and disease history we face sometimes, inadequate competence in the assessment of the clinical symptoms and laboratory data are of no less importance. All these moments are supported by the author's own observations. Special emphasis is laid on the causes of diagnostic errors occurring in the diagnosis of primary chronic pyelonephritis (PCPN), especially of its latent form, renal amyloidosis, focal nephritis, toxic or toxico-infectious kidneys, concomitant diffuse renal lesions, and on the etiology of the nephrotic syndrome (NS). The author substantiates inaccuracy of the concept of a potential development of the NS in patients suffering from PCPN. The author holds that if PCPN patients manifest the NS, it means that PCPN may be coupled with certain DRL complicated by the NS.
 ...
PMID:[Real errors in the diagnosis of well-known diffuse kidney lesions and their causes (critical comments. The author's own observations)]. 194 29

Investigation of renal biopsy specimens from 488 patients with diabetic glomerulosclerosis (DGS) of varying severity revealed the following: 1) The severity of DGS increases with the duration of the diabetes. 2) As the severity of DGS increases, it is complicated with increasing frequency by exudative changes, which correspond in detail to hyperperfusion lesions described in the literature. 3) As the severity of DGS increases, the severity of arteriolosclerosis and the incidence of nephrotic syndrome increase significantly. 4) The 5- and 10-year renal survival rates are highest for those diabetic patients in whom the tubules and renal cortical interstitium are of normal appearance. These survival rates are diminished if any of the following are present at the time of biopsy: a) interstitial fibrosis; b) hyperperfusion lesions; c) nephrotic syndrome; d) elevation of the serum creatinine concentration to more than 1.3 mg%. 5) No significant correlation was found between renal survival rate and age, sex, or type of diabetes. 6) The inflammation of the renal interstitium seen in diabetes does not differ from that seen in chronic glomerulonephritis. Monocytes, macrophages, T lymphocytes, fibroblasts and fibrocytes play the major role in this inflammation. This inflammatory process is considered to represent not pyelonephritis, but rather an auto-immune process. In other words, it is proposed that the diabetic kidney fails not only as a result of non-specific glomerular lesions (hyperperfusion lesions) but also because of non-specific tubulointerstitial changes, whereas diabetic glomerulosclerosis alone does not lead to chronic renal failure.
 ...
PMID:The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosis. 206 8

Efficiency of ceftriaxone (Rocephin Hoffman Laroche) was assessed in 16 children aged between 3 and 14 years and in 4 adults aged between 17 and 70 years with severe infections of the urinary and respiratory tracts caused by E. coli. S. pneumoniae, P. aeruginosa, P. mirabilis or enterococci. Pyelonephritis as a sole pathology was diagnosed in 10 patients whereas in further 8 patients it complicated other diseases (nephrotic syndrome, hepatitis, cholangitis, leukemia). Pneumonia complicated nephritis leukemia or lymphoma in 8 children. Peritonitis was diagnosed in 1 adult patient. Ceftriaxone was given in a single daily dose of 50 mg/kg to all children and 2.0 g to adult patients for 7-10 days. No adverse reactions were noted. Clinical improvement was achieved in all treated patients. Cultures became negative in 17 cases after the treatment. Significant bacteremia caused by P. aeruginosa persisted in 2 patients and by E. coli in 1 patient. No toxic effects on liver, renal, pancreatic and bone marrow functioning were seen. Ceftriaxone may be safely and efficiently used for the treatment of the urinary and respiratory infections.
 ...
PMID:[Use of ceftriaxone in urinary and respiratory tract infections]. 223 13

Altogether 85 patients with a history of hemorrhagic fever and the nephrotic syndrome (HFNS) were examined at different stages after the disease, characterizing the status of the tubulointerstitial apparatus of the kidneys. Almost half of the patients who suffered this disease manifested a decrease in the capacity of the kidneys for osmotic concentration of urine under the conditions of deprivation for 36 hours, and in acid-secretory function of the kidneys under induced acidosis and clearance of uric acid. Ultrasonic studies demonstrated that part of the patients had uni- or bilateral indurations in the renal parenchyma. In 16% of the examined, these alterations may be related to superaddition of pyelonephritis after HFNS. The nature of tubulointerstitial lesions remains unknown in other cases and thus requires a further study. The recovery of tubular functions of the kidneys following HFNS continues for 3 years. In view of this fact patients with a history of this disease need prolonged follow-up.
 ...
PMID:[Tubulointerstitial changes in patients with a history of hemorrhagic fever with renal syndrome]. 257 73

Levamisole (2.1-3.1 mg/kg twice a week) was administered to 6 children aged between 20 months and 6.5 years for 1 to 4 months. All children suffered form the renal diseases exacerbation (nephrotic syndrome and pyelonephritis--2 children, lipoid nephrosis and pyelonephritis--2 children, pyelonephritis with glomerular reactions--1 child, recurrent pyelonephritis--1 child) due to recurrent respiratory infections levamisole improved both clinical and biochemical parameters of renal disease. Subsequent respiratory infections were milder and less frequent. Transient decrease in thrombocyte count was seen in 4 children after 2-8 weeks of therapy with levamisole. An increase in AspAT and (or) AlAT was noted in 2 children after 1-2 months of therapy. Levamisole was withdrawn in 2 children after 30 days due to an increase in AspAT activity, prolongation of blood clotting time and thrombocytopenia.
 ...
PMID:[Administration of levamisole to children with kidney disease exacerbation caused by recurrent respiratory infections]. 263 40

The coincidence of systemic amyloidosis and xanthogranulomatous pyelonephritis has been reported previously only once. Clinical findings, such as the nephrotic syndrome, cardiac and autonomic nervous system dysfunction, and adrenal insufficiency, are suggestive and a thorough investigation to rule out other causes of secondary amyloidosis is warranted. We report a case of xanthogranulomatous pyelonephritis associated with secondary systemic amyloidosis and the nephrotic syndrome. Treatment consisted of nephrectomy and intensive supportive care. The unique clinical, radiographic and pathological aspects of this case are discussed.
 ...
PMID:Xanthogranulomatous pyelonephritis and amyloidosis: a rare association. 265 19

A case of an 11-year-old boy is presented who had developed a severe nephrotic syndrome with massive edema, ascites, hydrothorax (protein loss with the urine up to 19 gr/24 h) 7 months after a successful kidney transplantation from a 16 years dead donor and a successfully treated crisis of transplant rejection by a good tissue compatibility. The needle renal biopsy revealed membranous glomerulonephritis I-II histological stage with data of rejection crisis by a basic disease of vesicoureteral refluxes and chronic pyelonephritis. Treatment with heparin, dipyridamole, human albumin, diuretics, sandimun and prednisolone led to a substantial improvement--mastered nephrotic syndrome, lowered to 1 g/24 h proteinuria and normal renal function.
 ...
PMID:["De novo" glomerulonephritis in the transplanted kidney]. 266 43


<< Previous 1 2 3 4 5 6 Next >>