Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A report is presented on a nine year old girl in whom a Spitz-Holter valve had to be implanted after operation on a meningomyelocele while a neonate. Because of a macrohematuria and a hypochromic anemia, she was admitted as an inpatient. In addition, there was a pyuria with bilateral hydronephrosis. The clinical picture was initially misinterpreted as hemorrhagic cystitis with ascending pyelonephritis in neurogenic bladder. Only the reduction of serum complement suggested the presence of a shunt nephritis. The diagnosis was verified by kidney biopsy. After removal of the infected valve system, there was a prompt normalization of all laboratory parameters. Besides description of the case history, above all the diagnostic problems of this rare syndrome, which is nevertheless of practical importance, are dealth with.
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PMID:[Clinical findings and diagnostic problems in a case of shunt nephritis. (author's transl)]. 719 34

In-111-leukocyte scanning has recently been introduced as a clinically effective method for detecting inflammatory disease and abscesses. The authors present six cases that demonstrate the usefulness of this new technique in suspected inflammatory renal disease. Two patients had renal abscesses, two had acute pyelonephritis, one had acute focal bacterial nephritis (acute lobar nephronia), and one had a transitional cell carcinoma with associated acute and chronic inflammation.
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PMID:In-111-leukocyte scanning in inflammatory renal disease. 722 73

The clinical and pathological findings are reviewed in ten cases where renal biopsy showed abnormalities predominantly within the interstitium. In six the nephritis was considered to be drug-induced; in two the aetiology was slightly obscure but the most likely diagnosis was considered to be sarcoidosis. Of the remaining two cases one was chronic pyelonephritis and the other polyarteritis nodosa. The diagnosis and pathogenesis of the renal lesions are discussed and attention is drawn to the importance of distinguishing primary interstitial changes from those found in association with glomerular disease.
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PMID:Interstitial nephritis. 725 4

Histological lesions were observed in the kidneys of 77 (32.5%) of 237 rabbits which were either found dead or were killed because they were unwell, and in 19 (25%) of 75 apparently healthy adult rabbits. Lesions associated with an infectious process such as renal abscesses, staphylococcal nephritis, pyelonephritis and pyelitis were the principal finding in rabbits up to 5 months of age, while renal fibrosis, with or without dystrophic calcification, was the most common lesion observed in rabbits aged over 10 months. Spontaneous amyloidosis was seen in 2 rabbits.
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PMID:Kidney disease in the rabbit: a histological survey. 728 77

Pyelonephritis during pregnancy was found to have a higher incidence when the patient's history contained some indication of an earlier renal disease. Pregnancy associated with chronic nephritis has to be interrupted in the first trimester as the particular conditions of pregnancy predispose to pyelonephritis. Provided pregnancy pyelonephritis is diagnosed and treated early enough the incidence of intrauterine fetal death, premature, birth and perinatal fetal loss will not be higher than the average, but developmental retardation has a slightly higher incidence. The degree of renal disturbance not only increase the probability of pyelonephritis but also the damage suffered by the mother and fetus. The prevention of inflammatory renal and appropriate treatment of inflammatory renal diseases and the constant control of the patient is the task of prenatal and nephrological care, so as to avoid early and late complications.
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PMID:Effect of pyelonephritis during pregnancy on mother and fetus. 732 16

A 3-year survey of patient referrals and case material in pediatric nephrology is evaluated to provide a data base for future projection of patient needs. In the 3-year period between January 1978 to December 1980, 538 pediatric patients with renal and electrolyte disorders were evaluated and treated. The principle reasons for the referrals were: hematuria (23%), hypertension (5%), nephrotic syndrome (7%), non-acute glomerulopathies (11%), acute glomerulonephritis (3%), fluid-electrolyte disorders (29%), urinary tract infections (6%), and others. Of the 538 patients, 99 underwent percutaneous renal biopsies under ultrasound guidance. The indications and results of the renal biopsies were also reviewed. The accrual of 18 chronic dialysis patients over a 36-month period is analyzed and presented. The ages of the patients were 4 to 16 years. They weighed from 16 to 51 kg. The primary renal diseases were objective uropathy, chronic glomerulonephritis, membrano-proliferative nephritis, chronic pyelonephritis, focal glomerulonephritis, lupus nephritis and others. All children, except 9 received kidney transplantations. The annual incidence of end-stage renal failure was 4 per million population.
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PMID:A 3-year survey of referral pattern and case material in pediatric nephrology. 734 35

Circulating antibody to Tamm-Horstall protein (THP) was measured using a radioimmunoassay in forty-five patients on maintenance hemodialysis and compared to levels of antibody titers measured in sera from ten healthy controls. The etiology of the end-stage kidney disease in the patient population was polycystic kidney disease in thirteen, glomerulonephritis in fourteen, diabetic nephropathy in nine, interstial nephritis and chronic pyelonephritis in three each, multiple myeloma in two, and urinary tract obstruction in one. Four patients had significantly elevated titers of antibody to THP but shared no other unifying characteristics. The results also indicate that none of the groups studied had mean antibody titers significantly different from controls. Furthermore, no general trend was apparent between levels of antibody to THP and number of months on dialysis. Observations made during the study revealed that heparinized samples of blood had lower titers of antibody to THP than did non-heparinized samples from the same patient. This finding was repeated when other anti-coagulants, i.e., ethylenediaminetetraacetate (EDTA) and sodium citrate, were used. Titers returned toward normal when CaCl2 was added back to samples anticoagulated with EDTA and sodium citrate. This suggests that clotting factors, probably fibrinogen, interfered with the measurement of antibody titers. Therefore, only serum should be used in further investigations of THP antibody using this assay.
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PMID:Tamm-Horsfall protein antibody in patients with end-stage kidney disease. 739 72

The carcinogenic effects of aniline and norharman given alone or in combination were examined in rats. Neoplastic changes including hyperplastic changes of the urinary bladder were not found in all groups. Papillomas of forestomach were observed in 5 rats out of 110 rats. However, this was not significantly different among the groups. Pyelonephritis or chronic nephritis were also seen in all groups. Hematological and blood biochemical analysis did not show any notable difference in the animals treated with aniline and/or norharman.
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PMID:Chronic effects of norharman in rats treated with aniline. 741 22

Activity of the kallikrein-kinin system and proteinase inhibitors were studied in blood plasma of children at various stages of tubulointerstitial nephritis, pyelonephritis and dysmetabolic nephropathy. Similar alterations in the activities of kallikrein-kinin system and in the rate of proteolysis inhibition were observed in tubulointerstitial nephritis and pyelonephritis. Supplementary demonstrations were obtained about development of inflammation in tubulointerstitial nephritis. Absence of the kallikrein-kinin system activation and a decrease in the alpha 2-macroglobulin content were detected in dysmetabolic nephropathy. Definite components of the kallikrein-kinin system and the proteolysis inhibitors may be used as indicators in differential diagnosis of tubulointerstitial nephritis and dysmetabolic nephropathy.
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PMID:[The kallikrein-kinin system and blood plasma proteolysis inhibitors in various childhood nephropathies]. 752 46

Acute tubulointerstitial nephritis (ATIN) is divided into two groups; acute pyelonephritis (APN) and ATIN associated with systemic infections. APN is generally occurred in females through the urinary tract. The causative organisms are gram-negative enteric bacteria, of which E. coli is the most common. Since antibiotics were used for the treatment of the infection, the prognosis became favorable, except for the presence of underlying diseases. On the other hand, ATIN in systemic infection is characterized by the association of acute renal dysfunction and infiltration of the interstitium by inflammatory cells. Renal biopsy is needed for adequate diagnosis. Since antibiotic era, the incidence of ATIN decreased.
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PMID:[Acute tubulointerstitial nephritis in acute infection]. 756 34


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