Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred patients were examined: 70 with diffuse increased parenchymal echogenicity and 30 with focal increased echogenicity. The increase of echogenicity was assessed in degree and in diffuse increased parenchymal echogenicity were considered persistence or disappearance of the corticomedullary boundary. An increased diffuse echogenicity with distinctness of the corticomedullary boundary was observed in chronic GNF (36), nephroangiosclerosis (15) and amyloidosis. Diffuse increased echogenicity without distinctness of the corticomedullary boundary was observed in uratic interstitial nephropathy (13) and in chronic GNF with advanced lesions (4). Focal increased echogenicity occurred in chronic pyelonephritis (11), in tumors (18) and in renal tuberculosis (1). Renal carcinomas showed an echogenicity of I degree in 7 cases and an echogenicity of II degree in 1 case. The angiomyolipomas always showed an echogenicity of II degree, as did the liposarcoma. Differential diagnosis among parenchymal renal diseases which are responsible for diffuse increased echogenicity is impossible; in fact there is no correlation between the degree of renal parenchymal echogenicity and type of the disease. The focal increased echogenicity caused by chronic pyelonephritis is correctly diagnosed using ultrasound. The hyperechogenic tumors, at present, cannot be characterized on the basis of the sonographic features.
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PMID:[Difficulty in the differentiation of renal parenchymal hyperechogenicity]. 330 77

Renal replacement lipomatosis (RRL) is a rare condition that occurs as an end result of renal atrophy or destruction of renal parenchyma by excessive lipomatous tissue in renal sinus and perinephric space. We report a case of RRL presenting as a right renal mass clinically. Intra-venous pyelography and renal scan revealed a left non-functioning kidney. A left nephrectomy was performed. After histopathological examination and extensive literature search, a diagnosis of RRL was given. In majority of cases, it is associated with renal calculi. Idiopathic variety is not common. It is a rare entity and the diagnosis may be missed due to lack of experience. It has to be differentiated from other fat-containing tumors such as renal lipoma, xanthogranulomatous pyelonephritis, angiomyolipoma and liposarcoma.
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PMID:Idiopathic renal replacement lipomatosis: a rare renal pseudo tumor. 2502 15

Renal replacement lipomatosis is a condition characterized by varying degrees of renal parenchymal atrophy and perirenal fibrofatty proliferation secondary to chronic inflammation such as xanthogranulomatous pyelonephritis. In severe cases, imaging findings can be misdiagnosed as retroperitoneal liposarcoma.
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PMID:Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma. 2952 92

In 2009, Tanas et al reported unusual changes in the perinephric fat, mimicking well-differentiated liposarcoma. We report 11 perinephric masses showing similar changes but chiefly arising in patients with non-neoplastic renal disease. Tissue from 11 perinephric masses was retrieved, and immunohistochemistry for IgG/IgG4 and fluorescence in situ hybridization (FISH) for MDM2 amplification was performed. Clinical information was obtained. Cases occurred in 10 males and 1 female (43-84 years of age; median, 63.5 years). Ten patients presented with perinephric masses (size range, 2-28 cm), and one was an incidental finding. Four patients had bilateral or multiple masses. Underlying renal disease included diabetes mellitus (n = 3), end-stage kidney (n = 2), diabetes and end-stage kidney disease (n = 1), chronic pyelonephritis (n = 1), and non-invasive high-grade papillary urothelial carcinoma of the renal pelvis (n = 1). Three patients were not known to have renal disease. Most tumors were submitted as "well-differentiated liposarcoma." The masses consisted of mature fat, myxoid stroma, moderately variable spindled to stellate cells and a mixed inflammatory cell infiltrate. Enlarged, hyperchromatic stromal cells were absent. IgG4-positive plasma cells and MDM2 amplification were absent in all tested cases. Clinical follow-up (11 patients; range, 1-120 months; median, 24 months) showed absent or stable disease in 9 patients; 2 died of unrelated causes. This distinctive pseudoneoplasm usually occurs in association with non-neoplastic renal disease, although similar changes may be identified in the perinephric fat of patients with renal carcinoma. Morphologic evaluation and FISH for MDM2 amplification should allow its distinction from liposarcoma and other mimics.
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PMID:Perinephric myxoid pseudotumor of fat: a distinctive pseudoneoplasm most often associated with non-neoplastic renal disease. 3082 21