Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The survival curves and the incidence of spontaneous diseases were studied in a population of SENCAR mice, a stock derived by a selected breeding protocol for enhanced susceptibility to chemical carcinogenesis in the skin. SENCAR mice proved to be as long-lived as other mouse strains or stocks, including one of their parental lines, Charles River CD-1. The most frequently occurring neoplasias in SENCAR mice were lymphoma, myeloid leukemia and reticulum cell sarcoma. Other frequently occurring neoplastic diseases included lung adenomas and carcinoma and mammary gland carcinoma. However, the incidence of these tumors was not higher than the incidence in CD-1 mice or other mouse strains or stocks. A variety of non-neoplastic diseases, both inflammatory and degenerative, were also observed in old mice. The most common were liver, spleen and kidney amyloidosis, pyelonephritis and papillary necrosis. These data indicate that selective breeding for susceptibility to chemical carcinogenesis has not produced a concomitant increase in the incidence of spontaneous neoplastic and non-neoplastic disease.
 ...
PMID:Survival curves and incidence of neoplastic and non-neoplastic disease in SENCAR mice. 405 83

Atypical organ and endometrial changes in 2 female patients under pe rmanent acyclic therapy with Lyndiol are reported. The 1st patient had undergone a bilateral nephrectomy for contracted kidneys due to pyelonephritis and died in uremic coma after extracorporal dialysis, bef ore the renal transplantation could be performed. She had been treated for profuse menorrhagia with 5 mg Lyndiol for 11 weeks. The so-called therapeutic pseudopregnancy found at the postmortem examination was attributed to the unintended accumulation of hormones due to the absence of the renal excretory organs as well as to liver damage from uremia and steroids. Besides the uremic damage, the administered steroids are obviously also responsible for the unusually extensive necroses found in the liver and the adrenal glands. In the 2nd case, permanent (15 months) therapy with Lyndiol was prescribed in order to eliminate meno-metrorhagias in chronic myelosis. Curettages were performed 2, 11, 14, and 21 months after treatment was begun. Besides the known contrary glandular and stroma reaction at the glandular epithelium as sign of its exhaustion, biopsy controls also revealed very extensive regressive chan ges similar to those seen in glandular hyperplasia, and also atypical regenerates. Characteristic features of differentiation from the choriogenic Arias-Stella phenomenon and from incipient carcinoma of the corpus uteri are pointed out.
 ...
PMID:[Atypical organ-oriented effects of so-called ovulation inhibitors following bilateral nephrectomy, as well as unusual endometrial changes during long-term acyclic therapy for chronic myelosis]. 1215 26