Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Analysis of data from the Canadian National Renal Failure Register indicates that Canadian Natives are at much higher risk for end-stage renal disease (ESRD) than the Canadian population in general. Using two population estimates for the total Native population, the age-standardized incidence rate of newly registered ESRD cases between 1981 and 1986 among Natives was at least 2.5 times (and may be as high as four times) the national rate. Natives were particularly at higher risk for ESRD to diabetes, glomerulonephritis, and pyelonephritis, whereas for the other causes the risk was no different from that of other Canadians. As technologically sophisticated treatment facilities are only available in major urban centers, Native ESRD patients and their families living in remote areas of Canada are faced with major psychosocial disruptions of relocation.
 ...
PMID:Excessive burden of end-state renal disease among Canadian Indians: a national survey. 278 48

The children born to mothers suffering from glomerulonephritis, pyelonephritis and hereditary nephritis were followed up for 4-5 and more years. This allowed a conclusion about a considerable rate of the birth of children with pathology of the urinary system organs (USO) and with diseases of other organs which were diagnosed for the first time at the age of 3-10 years as a result of goal-oriented investigations. The groups of the children born to women with renal diseases were marked by a high perinatal lethality studied by means of retrospective questionnaire. As for the structure of the USO diseases, the children manifested the predominance of the disease patterns associated with dysembryogenesis at the organ (anatomic abnormalities), tissue (dysplasia of the renal tissue) and at the cellular levels (metabolic nephropathies). In children born to women with hereditary nephritis, USO pathology was of the same kind and occurred only in the form of hereditary nephritis, which corresponds to the concepts of monogenously inherited pathology. The demonstration during pregnancy of a considerable rate of the environmental effects capable of exerting a damaging action on the embryonal development of children born to women with glomerulo- and pyelonephritis suggests a concomitant genesis of USO diseases in children born to mothers suffering from renal diseases. The authors discuss measures aimed at the prevention or reduction of the incidence of USO pathology in children as well as at the recognition of pathologies in children born to women with renal diseases at the predisease stage.
 ...
PMID:[Health status of children born to women with renal pathology]. 279 14

Glomerulonephritis patients transplanted with cadaver kidneys had a significantly higher one-year graft survival when immunosuppressed with cyclosporin rather than standard therapy (80% versus 59%, p less than 10(-5]. For nephrosclerosis patients the corresponding rates were 70% and 59% (p greater than 0.05); and in those with antecedent diabetes mellitus, polycystic kidney, and pyelonephritis the differences were negligible. In glomerulonephritis patients, but not in the other groups, cyclosporin was additive to the effect of transfusions and of HLA-A, B and HLA-Dr matching.
 ...
PMID:Preferential effectiveness of cyclosporin in patients receiving kidney transplants after glomerulonephritis. 285 55

The urinary enzymes alanine aminopeptidase (EC 3.4.11.2), alkaline phosphatase (EC 3.1.3.1), gamma-glutamyltransferase (EC 2.3.2.2), N-acetyl-beta-D-glucosaminidase (EC 3.2.1.30), and ribonuclease (EC 3.1.4.22) were measured in 66 healthy persons and 52 patients suffering from chronic renal diseases (pyelonephritis, glomerulonephritis). The residual renal function of patients characterized by 99mTc-diethylenetriaminopentaacetate isotope clearance was only moderately reduced. Except for gamma-glutamyltransferase, patients generally showed increased urinary enzyme excretions. N-Acetyl-beta-D-glucosaminidase was more sensitive to detect renal dysfunction than the other enzymes and the conventional parameters serum creatinine, total protein excretion, and the measurement of glomerular filtration rate. The determination of this enzyme can be recommended as a suitable diagnostic parameter in nephrology.
 ...
PMID:Diagnostic significance of different urinary enzymes in patients suffering from chronic renal diseases. 289 Apr 51

A total of 530 patients with a variety of hypertensive conditions, including 476 patients with labile and stable essential hypertension, 40 with hypertensive chronic diffuse glomerulonephritis and hypertensive chronic pyelonephritis, and 14 with vasorenal hypertension, were investigated. Structure and function of target organs (the heart and the kidneys) were assessed by means of echocardiography (530) and intravital morphologic studies of renal biopsy specimens (89). A heterogeneous nature of hypertrophic developments associated with essential hypertension was demonstrated, with adequate, inadequate, disproportionate and excessive hypertrophy identified, while no correlation could be found between the kind of hypertension and the degree and nature of hypertrophy. Renal morphologic changes were also shown to be heterogeneous in labile and stable arterial hypertension, and early involvement of the renal mechanism presenting as structural changes was found to be possible.
 ...
PMID:[Lesions of target organs in arterial hypertension]. 294 50

Using standard real time sonography, renal cortical echogenicity, renal length, intrarenal cystic structures and renal calculi were evaluated in 63 patients (30 men, 33 women) in end-stage renal parenchymal diseases (glomerulonephritis n = 21, diabetic glomerulosclerosis n = 9, analgesic nephropathy n = 14, chronic atrophic pyelonephritis n = 19). Patients with glomerulonephritis and diabetic glomerulosclerosis presented with larger kidneys and only slightly increased cortical echogenicity as compared to analgesic nephropathy and chronic atrophic pyelonephritis. In addition, intrarenal cystic structures were found in 50% of the patients with analgesic nephropathy and in 31% of the patients with pyelonephritis, compared with only 14% and 11% in patients with glomerulonephritis and diabetic glomerulosclerosis, respectively. Intrarenal calcifications were more frequent in pyelonephritis and analgesic nephropathy. In end-stage renal parenchymal disease, sonography might be able to distinguish between different types of renal medical disorders.
 ...
PMID:[Ultrasound in terminal renal failure--etiologic conclusions?]. 307 Jul 47

40 patients with arterial hypertension II stage, 51 patients with chronic pyelonephritis and glomerulonephritis and a control group of IO healthy persons were examined during a free from medicamentous treatment period by a group of clearance tests in order to study the excretory system function and the degree of its affection in the earliest phases of the diseases studied. By means of the isotopic clearances of 169Yb-EDTA for determinations of the glomerular filtration, 131-I-hippuran for effective renal plasma circulation, the electrolytic clearances of Na, K, Ca, Cl and creatinine, the volume of the water excretion and the lithium clearance, the degree of the renal lesion was determined in every patient examined by the deviations from the normal values and the role of the different nephron sections as well. The results of the study revealed that the best tests for evaluation of the renal function in chronic renal diseases are the electrolyte clearances of Na, K, Ca, Cl, and in arterial hypertension--the lithium clearance.
 ...
PMID:[A comparison of the diagnostic reliability of the results of isotopic and routine clearance studies in essential and symptomatic hypertension]. 313 28

At the end of 1985 there were 5482 patients known to the Registry who started renal replacement therapy (RRT) between the ages of 6 months and 15 years. Of these, approximately 25% had died, 30% were still aged less than 15 years, and the other 45% were older. The acceptance rate of new patients over the last 10 years has slowly but steadily increased; six new paediatric patients per million child population probably represents the likely needs of the near future. Hospital haemodialysis remained the main form of renal replacement therapy in new patients, while 3 years after start of RRT, transplantation became the most frequently used replacement therapy; CAPD appeared to be used mainly in children with a short waiting time for transplantation. Out of the 384 grafts reported in 1985, only 16% were from living related donors; among 321 cadaver grafts, 24% were second and only 3% were third grafts. Glomerulonephritis and pyelonephritis accounted for 50% of all primary renal diseases. During the last 5 years, the proportion with glomerulonephritis seems to have decreased slightly. Hyperkalaemia and fluid overload have still to be considered the main causes of death. Only in 17% of all cases was the cause of death reported as unknown or undetermined.
 ...
PMID:Demography of dialysis and transplantation in children in Europe, 1985. Report from the European Dialysis and Transplant Association Registry. 314 94

Between 1962 and 1970, 36 children with acute biopsy-proven poststreptococcal glomerulonephritis (PSGN) entered a prospective long-term follow-up study. The initial biopsies were scored into four histological grades using criteria based on endocapillary proliferation, leucocyte infiltration, epithelial "hump" and crescent formation; 5 patients had grade-1 (least severe), 14 grade-2, 15 grade-3 and 2 grade-4 biopsies. Two children died from rapidly progressive glomerulonephritis; both had grade-4 biopsies. Early repeat biopsy in 12 patients showed improvement in all but one patient who progressed from grade 2 to type 2 mesangiocapillary glomerulonephritis (MCGN). The initial biopsy grade correlated significantly with heavy proteinuria (chi2 = 9.73, P less than 0.01) but not with hypertension, haematuria or renal functional impairment. Follow-up observations were made after mean periods of 9.5 years (range 5.4-12.4 years; 32 subjects) and 19.0 years (range 14.6-22 years; 30 subjects). None of the survivors had an abnormal plasma creatinine. Only one patient (grade-3 biopsy), a female with a subsequent history of recurrent pyelonephritis, was hypertensive. Isolated microscopic haematuria persisted in 1 grade-2 and 2 grade-3 subjects. One grade-2 subject had proteinuria secondary to MCGN and one grade-3 subject had mild proteinuria and borderline hypertension. Although 20% of subjects had urinary abnormalities, we conclude that the long-term outcome of PSGN in children is excellent.
 ...
PMID:Poststreptococcal glomerulonephritis in children: clinicopathological correlations and long-term prognosis. 315 45

1. The use of CsA in cadaver donor transplants has apparently overcome the effect of original disease one-year graft survival rates. Only SLE patients had lower than average graft survival rates in CsA-treated, first transplants. 2. Since 1970, the proportion of diabetics transplanted has increased tenfold. The proportions of transplants for glomerulonephritis and pyelonephritis have decreased over the years. 3. A beneficial effect of pretransplant blood transfusions, was observed in almost all of the disease groups. 4. HLA matching, particularly for HLA-B, DR antigens, has resulted in increased graft survival rates in the major disease categories. Small numbers of zero mismatched grafts prevented a more detailed analysis. 5. Whereas CsA consistently enhanced graft survival rates for first cadaver transplants, this drug had a much smaller effect in living donor transplants. A 14% increase was seen in cadaver donor transplants due to CsA, compared to 2% (siblings), 1% (parent), and 4% (child) for the living donor grafts.
 ...
PMID:Original disease of the recipient. 315 36


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>