Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of subinhibitory doses of 25 antibiotics on the antilysozyme property of enterobacteria considered as a marker of their persistence was studied. This provided dividing the antibiotics into 3 groups: antibiotics increasing the bacterial capacity for lysozyme degradation, antibiotics indifferent with respect to this property and antibiotics decreasing it. Decreasing of the Salmonella antilysozyme activity by gentamicin under experimental conditions promoted suppression of the bacteria parasitism in Hep-2 cells. Clinical and laboratory studies on the effect of antibiotic therapy under the control of the time course of the antilysozyme property of the pathogen in patients with acute dysentery, pyelonephritis and inflammatory processes in the female genitalia showed that the use of the antibiotics increasing this property in the pathogen was not advisable which was confirmed by the absence of significant clinical improvement in the patients and necessity of prolonging the sanative period.
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PMID:[Bacterial antilysozyme activity and its regulation by antibiotics]. 367 41

The initial interaction between uroepithelial cells and Escherichia coli which has adhesive or invasive activity for cultured cells was studied ultrastructurally at the in situ of infection in the model of ascending pyelonephritis in mice. The densely piliated adhesive strain E77156 isolated from the urine of a patient with urinary tract infection adhered to the pelvic and renal tubular epithelial cells and colonized on their cell surfaces and thereafter in the cytoplasm. The non-piliated invasive strain 633-65 isolated from a patient with dysentery-like syndrome did not colonize on the uroepithelial cell surfaces but easily penetrated into the cytoplasm of these cells. Thereafter multiplication was observed in their cytoplasm. Neither strain scarcely penetrated into the interstitium via the basement membrane of the renal tubules.
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PMID:Experimental pyelonephritis in mice following ascending infection with C. coli. Acute phase. 702 Mar 31

Using medical manuscripts and texts from the Byzantine period (330-1453), this article describes various, to date little discussed, aspects of Byzantine nosology, public health and therapeutics. Many diseases in the Byzantine era were widespread and had a high morbidity such as respiratory disease, various kinds of anaemia, pestilential diseases (e.g. quartan fever, plague, dysentery and cholera), parasitic diseases, orthopaedic, rheumatic and psychiatric disorders, trachoma and alcoholism. Other very serious and relatively frequent conditions included leprosy, mania, gout, cancerous tumours and ulcers. Important elements of nephrology and various renal diseases were described and investigated, such as acute and chronic renal failure, acute and chronic nephritis, pyelonephritis, necrotic renal diseases, crush syndrome, and ulcers of the kidneys, i.e. tuberculosis or renal tumours. The microhistology and physiology of the kidneys were first studied by Oribasius, who discerned the existence of the capillaries--tau rho iota chi omicron epsilon iota delta eta--some centuries before Malpighi. He also correctly described the blood circulation, general and pulmonary, as a precursor to Harvey. The first hospitals were organised during the Byzantine period, and the practice of Byzantine medical science and its social applications were regulated by a special medical legislation and deontology. Byzantine medicine was fruitfully connected with the Christian faith and developed the supreme model of the saints unmercenary--alpha nu alpha rho gamma epsilon rho omicron iota--physicians such as Cosmas and Damian (3rd century), Panteleemon (3rd-4th centuries) and the women physicians and miracle-worker saints, Zenais and Philonilla (1st century), the 'friends of peace', and Hermione (1st-2nd centuries).
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PMID:Diseases in the Byzantine world with special emphasis on the nephropathies. 918 37

Author presents and analyses informations of non-medical texts of Byzantine historians and chroniclers concerning diseases of Byzantine emperors, concluding that diseases were implicated in certain political and military difficulties. Only one third of the emperors died due to natural causes (i.e. illnesses). Some historians, such as Anna Comnena and Michael Psellos had studied medicine, both of them had excellent knowledge of medical theories of their times. Some diseases in Byzantium were widespread and had high morbidity. This material gives an indication that arthritis (resembling gout) tyrannised a great number of emperors. Contemporary historians maintain that the main causes of gout were overconsumption of alcoholic drinks and food. Other very serious conditions were acute and chronic pyelonephritis and urolithiasis. Relatively frequent conditions of the emperors included pestilential diseases (dysentery, typhoid fever, etc.), psychiatric disorders, epilepsy and arteriosclerosis.
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PMID:[Ill-conditioned rules on the throne of Byzantium]. 1571 71