Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The progression of renal failure was analyzed in 108 patients with mild to moderate renal impairment, none of whom had received any form of dietary protein, phosphate restriction or immunosuppressive treatment. The reciprocal of plasma creatinine was plotted against time using a minimum of six plasma creatinine values taken over at least six months (mean 13 values over 41 months). Plots indicated there was linear deterioration in 70 patients, non-linear deterioration in 15 and stable renal function in 24. Progressive renal failure was common in patients with glomerulonephritis, diabetic nephropathy, chronic pyelonephritis and polycystic kidney disease. Most patients with hypertensive nephrosclerosis, analgesic nephropathy and renal impairment following acute renal failure were stable. Among those with progressive impairment the mean rates of deterioration were significantly faster for patients with glomerulonephritis and diabetic nephropathy compared to those with chronic pyelonephritis, polycystic kidney disease and undiagnosed renal disease (p less than 0.01). Hence the underlying renal pathological changes appear to be important in determining progression of renal failure and also the subsequent rate of deterioration. For those with linear progression of renal failure there was a significant correlation between 24-h urinary protein excretion and the rate of deterioration. This relationship held for glomerulonephritis and chronic pyelonephritis as separate diagnostic groups only. Proteinuria, therefore, may be a useful prognostic index for the rate of progression of established renal failure. Calcium phosphate product correlated poorly with the rate of deterioration. We were unable to demonstrate a relationship between spontaneous protein intake and deterioration of renal function. However, patients prescribed high protein diets were not included in dietary analysis and we cannot, therefore, exclude the possibility that a high dietary protein intake may accelerate renal failure. Similarly we were unable to show a significant relationship between blood pressure and progression of renal failure although there were weak correlations between mean arterial pressure and rate of deterioration for chronic pyelonephritis and glomerulonephritis.
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PMID:Renal pathology and proteinuria determine progression in untreated mild/moderate chronic renal failure. 320 6

The beta2-microglobulin (beta2-MCG) test was done in 115 patients with an insulin dependent type of diabetes mellitus: 30 of them were without renal pathology, 58 had diabetes mellitus with diabetic nephropathy (DN), and 27 had concomitant chronic pyelonephritis. The effect of glucosuria and proteinuria on the beta2-MCG level was revealed. DN development and progress resulted in an increase in the beta2-MCG concentration in the blood that correlated with a decrease in the glomerular filtration. beta2-MCG urinary excretion grew in a clinically manifested DN stage only. Concomitant pyelonephritis in diabetes mellitus patients resulted mostly in a rise of the beta2-MCG level in the urine. Its concentration in the urine during the exacerbation of pyelonephritis exceeded the indices of the control group, on an average, by 467.9%. The beta2-MCG test is a valuable additional criterion in the differential diagnosis of DN in diabetes mellitus patients.
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PMID:[Beta 2-microglobulin in the diagnosis of kidney lesions in diabetes mellitus patients]. 351 58

Concentration and acidification capability was tested in 41 patients with chronic pyelonephritis (PN), 14 patients with chronic glomerulonephritis (GN), 16 patients with diabetic nephropathy (DNP) and 12 healthy controls. Significant differences appeared between PN and GN, PN and DNP comparing a quotient between percent of normal osmolarity and percent of normal creatinine clearance. Similar results were obtained using a quotient creatinine clearance/ammonia excretion, which enabled the differentiation of PN from the other groups. The tubular functions of concentration and ammonia excretion in relation to creatinine are clinically useful in the differentiation of pyelonephritis from glomerular kidney diseases.
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PMID:Tubular dysfunctions in the diagnostic differentiation of glomerulonephritis, pyelonephritis, and diabetic nephropathy. 397 78

We studied 182 patients with chronic renal failure by urinalysis and urine cultures. Of the patients 27 per cent had significant bacteriuria (more than 10(5) per ml.), 38 per cent had significant pyuria (more than 10 white blood cells per high power field), 19 per cent had urinary tract infection and 7 per cent had symptomatic urinary tract infection. All 12 patients with symptomatic urinary tract infection had significant bacteriuria and 11 had significant pyuria, while 1 had 5 to 10 white blood cells per high power field. Incidences of urinary tract infection differed depending on the primary renal disease (12, 13, 41 and 67 per cent for chronic glomerulonephritis, diabetic nephropathy, polycystic kidney and chronic pyelonephritis, respectively). Among the patients with chronic glomerulonephritis no significant differences were seen in frequencies of bacteriuria and urinary tract infection between male and female patients or between those who did and did not undergo hemodialysis. Also, no significant correlation was seen between bacteriuria and daily urine output but pyuria was significantly more frequent in oliguric patients or those on hemodialysis.
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PMID:Urinary tract infection in oliguric patients with chronic renal failure. 399 25

Forty-five women with diabetes mellitus and urinary tract infections have been followed an average of 34 mo on treatment protocols based on localization of infection as determined by the presence or absence of antibody-coated bacteria (ACB). Treatment was usually, but not exclusively, trimethoprim-sulfamethoxazole. Two weeks of oral therapy was equally efficacious to 6 wk of treatment in asymptomatic women with antibody-coated bacteria (ACB)-positive infection in eradicating bacteriuria. Recurrences in all groups were predominantly reinfections with differing serotypes or species of microorganisms. The sustained remission rate (fractional extraction) after initial treatment was similar to other reported groups, but possibly less efficacious with recurrences. Suppressive therapy with trimethoprim-sulfamethoxazole for repeated recurrences effectively prevented infection but provided no posttreatment benefit. A high prevalence of underlying structural genitourinary tract abnormalities, usually detectable on pelvic examination, and which were not direct consequences of diabetes mellitus, were possible contributing factors to recurrent infection in this patient group. Progressive elevation in serum creatinine in seven patients with initial ACB-positive infections appeared to relate more closely to diabetic nephropathy rather than chronic pyelonephritis. ACB-positivity correlated well with elevated serum antibody titers and the presence of underlying anatomic abnormalities, but ACB categorization did not lead to improved therapeutic strategy or outcome and hence was of limited clinical usefulness.
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PMID:The treatment of urinary tract infections in women with diabetes mellitus. 405 37

An earlier and more manifested affect of glomerular function was established during the examination of 35 patients with diabetic nephropathy, 14 of them in a stage of renal insufficiency, with the help of radioisotope clearance methods (of EDTA, labelled with 169Yb for the determination of glomerular function and of hippuran, labelled with 131J for the determination of the renal plasma flow). The renal plasma flow is affected to a considerably more restricted extent. The combination of diabetic nephropathy with chronic pyelonephritis, found in 10 patients, does not affect substantially the mentioned functions of the kidney, but additional investigations were considered necessary in that field. Bilateral symmetric alterations are more frequently the secretory and excretory segmentsmthe establishment of unilateral alterations may speak of the presence of chronic pyelonephritis of uropathic character. The radioisotope methods, because of their accessibility and less possibilities for errors are recommended for renal functional investigations.
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PMID:[A study of renal function using radioisotope methods in patients with diabetic nephropathy]. 421 76

Autopsies of all uraemic patients in Leningrad for three years, and materials of the City Nephrological Service have demonstrated that the structures of nephrological diseases in their early and terminal stages were different. Chronic glomerulonephritis has been noted in patients with normal renal function just as often as chronic pyelonephritis but the former prevails considerably among the causes of uraemia. The proportion of polycystic kidney disease, amyloidosis, and diabetic nephropathy increases in patients with chronic renal failure. Due to these changes and the difference in the death age of patients with various diseases the majority of patients suitable for treatment with long-term dialysis suffer from chronic glomerulonephritis and only 14.89-20.5% from chronic pyelonephritis.
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PMID:Epidemiology of chronic renal diseases. 622 4

The course of pregnancy and treatment of diabetes mellitus during pregnancy were studied in 111 patients (119 pregnancies), who had fallen ill with diabetes mellitus before 5 (11 cases), at the age of 6-10 (39 cases), and at the age of 11-15 (61 cases). There were no patients with mild forms of the disease; 41.6% patients had diabetes mellitus of medium severity, and 58.4% patients grave forms of the disease. Diabetic retinopathy was observed in 47% patients, diabetic nephropathy in 13% patients, signs of acute and chronic pyelonephritis in 8.8% patients. Perinatal mortality in the group under observation was 13.4%. In the patients who had fallen ill with diabetes mellitus later it was 5.7%, and it was observed only in unstable and unsatisfactory compensation of diabetes mellitus. In women who had suffered diabetes since childhood and adolescence, hydramnion and toxemia of pregnancy were recorded in 40% cases.
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PMID:[The course of pregnancy and diabetes mellitus in pregnant women with a long-standing disease]. 706 49

Making use of immunoelectrophoretic method for semiquantitative determination, the fibrin/fibrinogen degradation products (FDP) were determined in urine and blood serum of 63 patients with diabetes mellitus with various vascular-degenerative and inflammatory complications in the kidneys as well as of 23 clinically healthy subjects. FDP presence in urine was found mainly in patients with diabetic nephropathy (in 32.6%). FDP in blood serum was found with significantly increased values in diabetic nephropathies (mean 14.9 mg/ml) and particularly in their advanced forms (mean 16.4 mg/ml), whereas in diabetics with chronic pyelonephritis, their content was increased in single cases (mean 1.9 mg/ml). A moderately manifested correlation of FDP in urine and serum with blood urea, serum creatinine and creatinine clearance was established as well as partly with protein quantity in urine and diastolic arterial pressure. The determination of FDP in urine and blood serum could serve as an additional sign in the differentiation of diabetic nephropathy and chronic pyelonephritis in diabetic patients.
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PMID:[Fibrin fibrinogen degradation products in the urine and blood in patients with diabetes mellitus and renal complications]. 716 12

Circulating antibody to Tamm-Horstall protein (THP) was measured using a radioimmunoassay in forty-five patients on maintenance hemodialysis and compared to levels of antibody titers measured in sera from ten healthy controls. The etiology of the end-stage kidney disease in the patient population was polycystic kidney disease in thirteen, glomerulonephritis in fourteen, diabetic nephropathy in nine, interstial nephritis and chronic pyelonephritis in three each, multiple myeloma in two, and urinary tract obstruction in one. Four patients had significantly elevated titers of antibody to THP but shared no other unifying characteristics. The results also indicate that none of the groups studied had mean antibody titers significantly different from controls. Furthermore, no general trend was apparent between levels of antibody to THP and number of months on dialysis. Observations made during the study revealed that heparinized samples of blood had lower titers of antibody to THP than did non-heparinized samples from the same patient. This finding was repeated when other anti-coagulants, i.e., ethylenediaminetetraacetate (EDTA) and sodium citrate, were used. Titers returned toward normal when CaCl2 was added back to samples anticoagulated with EDTA and sodium citrate. This suggests that clotting factors, probably fibrinogen, interfered with the measurement of antibody titers. Therefore, only serum should be used in further investigations of THP antibody using this assay.
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PMID:Tamm-Horsfall protein antibody in patients with end-stage kidney disease. 739 72


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