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Query: UMLS:C0034186 (pyelonephritis)
 6,144 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 116 patients with acute and chronic pyelonephritis and in 66 healthy persons the total proteolytic, trypsin-like, catheptic, BAEE-esterase activities and the content of trypsin inhibitor were determined in blood serum and kidney tissue. The total proteolytic and catheptic activities were distinctly increased in blood serum and, especially, in kidney tissue under acute pyelonephritis. In chronic pyelonephritis the activity of cathepsins was decreased in blood serum. The trypsin-like activity tended to decrease both in blood serum and kidney. The BAEE-esterase activity was increased in kidney, particularly in acute pyelonephritis, but in blood serum it was decreased. The inhibitor of trypsin was not found in kidney; in blood serum its content was slightly increased in acute pyelonephritis but there were only slight alterations in the chronic disease.
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PMID:[Activity of proteolytic enzymes and trypsin inhibitor in blood serum and kidney in pyelonephritis]. 121 70

A study was designed to investigate and define the true incidence of chronic atrophic pyelonephritis; its contributing role as a cause of chronic renal failure. The study was designed to investigate and define the true incidence of chronic disease in affected individuals in a hospital based population. We relied on radiological and postmortem histopathological evidences of the disease. The results showed that radiologically detectable unilateral chronic atrophic pyelonephritis was found in only 15 out of 391 intravenous pyelograms performed on patients referred to the renal clinic (3.8 per cent) during the five-year study period; bilateral disease was not found. Histopathological evidence from postmortem studies showed evidence of chronic atrophic pyelonephritis in 12 out of 250 autopsies (4.8%). In a short term follow up of women with unilateral pyelonephritic scars, it was found that antihypertensive treatment and meticulous treatment of urinary tract infection prevented a decline in renal function and the outcome of pregnancy was satisfactory. Chronic atrophic pyelonephritis is a rare disease in adult Nigerians and seems to be a benign disease. It may be indolent and unrecognised in many patients.
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PMID:The rarity of chronic atrophic pyelonephritis in adults Nigerians. 261 2

The case history of 88 patients with blood cultures positive for Escherichia coli and evidence of systemic disease was reviewed, and the Escherichia coli blood isolates tested for P-fimbriation. Fifty-five strains (63%) were P-fimbriated. Patients with a positive urine culture had a higher incidence of P-fimbriated Escherichia coli strains (53/75, 71%) than patients with a negative urine culture (2/13, 15%). Patients with no predisposing factors, such as instrumentation of the urinary tract or a chronic disease, had a significantly higher frequency of P-fimbriated strains (31/36, 86%) compared to patients without such underlying factors (p less than 0.01). There was no significant difference in clinical parameters or in frequency of P-fimbriated strains between patients with one positive blood culture and those with two or more positive cultures. The high incidence of P-fimbriated Escherichia coli strains in these patients is thought to depend on the ability of such bacteria to cause acute pyelonephritis, which in many cases precedes Escherichia coli bacteremia.
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PMID:Occurrence of P-fimbriated Escherichia coli in patients with bacteremia. 286 94

Analyzing the data of a comprehensive examination of 372 patients admitted to hospital with a distinct clinical picture of acute pyelonephritis, the author shows that out of these patients' population, 278 (74.8%) had an active form of chronic disease running a latent course. At the same time 40.4% of cases were diagnosed to have chronic renal failure (CRF), stages IB-IIB. To determine the genuine character of renal injury, the author thinks it necessary to regard the symptom-complex of acute pyelonephritis as a consequence of the pyelonephritic process itself. In complicated cases of the diagnosis, biopsy of the kidney concerned is required. In 176 patients the final diagnosis was established by uroradiological examination, in 59 by means of the use of laboratory methods, and in 137 by biopsy of the involved kidney. It is recommended that patients with renal pathology should be kept under prolonged dispensary observation, particularly those with an initial stage of CRF.
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PMID:[Acute primary pyelonephritis or active phase of a latent form of chronic pyelonephritis?]. 407 14

Urinary tract infections are one of the most common bacterial infectious diseases in humans. Depending on the localization and the effectiveness of pathogenetic factors, various clinical pictures (lower urinary tract infection, pyelonephritis, asymptomatic bacteriuria) have to be differentiated. There are virulence factors of microorganisms on the one hand and defense mechanisms on the other, which influence the manifestation and the course of disease. The process of bacterial attachment to the epithelial cells of the boundary layer, the internalization and invasion of bacteria could be important for acute and chronic disease. Disturbances of local defense mechanisms, such as increased urinary glucose concentration in diabetes or variations of Tamm-Horsfall protein and defensin levels, may influence the course of infection. On the basis of microbiological and laboratory findings as well as the results of clinical and ultrasound procedures, the decision on the therapeutic strategy should be made. There are different treatment recommendations for acute uncomplicated and complicated cases as well as for chronic diseases. Future investigations should focus on effective therapeutic options for special immunocompromised patients in relation to the microbiological aspects and defense mechanisms of the host.
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PMID:[Nephrology-part 3: Urinary tract infections]. 1293 3

Leprosy is a chronic disease caused by Mycobacterium leprae, highly incapacitating, and with systemic involvement in some cases. Renal involvement has been reported in all forms of the disease, and it is more frequent in multibacillary forms. The clinical presentation is variable and is determined by the host immunologic system reaction to the bacilli. During the course of the disease there are the so called reactional states, in which the immune system reacts against the bacilli, exacerbating the clinical manifestations. Different renal lesions have been described in leprosy, including acute and chronic glomerulonephritis, interstitial nephritis, secondary amyloidosis and pyelonephritis. The exact mechanism that leads to glomerulonephritis in leprosy is not completely understood. Leprosy treatment includes rifampicin, dapsone and clofazimine. Prednisone and non-steroidal anti-inflammatory drugs may be used to control acute immunological episodes.
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PMID:Leprosy nephropathy: a review of clinical and histopathological features. 2565 21